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Interim guidance for the use of human papillomavirus DNA testing as an adjunct to cervical cytology for screening.
Obstet Gynecol 2004; 103(2):304-9OG

Abstract

Human papillomavirus (HPV) DNA testing was recently approved by the Food and Drug Administration for use as an adjunct to cytology for cervical cancer screening. To help provide guidance to clinicians and patients when using HPV DNA testing as an adjunct to cervical cytology for screening, a workshop was cosponsored by the National Institutes of Health-National Cancer Institute, American Society of Colposcopy and Cervical Pathology (ASCCP), and American Cancer Society. Consensus was reached based on a literature review, expert opinion, and unpublished results from large ongoing screening studies. The conclusions of the workshop were that HPV DNA testing may be added to cervical cytology for screening in women aged 30 years or more. Women whose results are negative by both HPV DNA testing and cytology should not be rescreened before 3 years. Women whose results are negative by cytology, but are high-risk HPV DNA positive, are at a relatively low risk of having high-grade cervical neoplasia, and colposcopy should not be performed routinely in this setting. Instead, HPV DNA testing along with cervical cytology should be repeated in these women at 6 to 12 months. If test results of either are abnormal, colposcopy should then be performed. This guidance should assist clinicians in utilizing HPV DNA testing in an effective manner, while minimizing unnecessary evaluations and treatments.

Authors+Show Affiliations

Department of Pathology, College of Physicians and Surgeons of Columbia University, Room 16-404 P&S Building, 630 West 168th Street, New York, NY 10032, USA. tcw1@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

14754700

Citation

Wright, Thomas C., et al. "Interim Guidance for the Use of Human Papillomavirus DNA Testing as an Adjunct to Cervical Cytology for Screening." Obstetrics and Gynecology, vol. 103, no. 2, 2004, pp. 304-9.
Wright TC, Schiffman M, Solomon D, et al. Interim guidance for the use of human papillomavirus DNA testing as an adjunct to cervical cytology for screening. Obstet Gynecol. 2004;103(2):304-9.
Wright, T. C., Schiffman, M., Solomon, D., Cox, J. T., Garcia, F., Goldie, S., ... Saslow, D. (2004). Interim guidance for the use of human papillomavirus DNA testing as an adjunct to cervical cytology for screening. Obstetrics and Gynecology, 103(2), pp. 304-9.
Wright TC, et al. Interim Guidance for the Use of Human Papillomavirus DNA Testing as an Adjunct to Cervical Cytology for Screening. Obstet Gynecol. 2004;103(2):304-9. PubMed PMID: 14754700.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interim guidance for the use of human papillomavirus DNA testing as an adjunct to cervical cytology for screening. AU - Wright,Thomas C,Jr AU - Schiffman,Mark, AU - Solomon,Diane, AU - Cox,J Thomas, AU - Garcia,Francisco, AU - Goldie,Sue, AU - Hatch,Kenneth, AU - Noller,Kenneth L, AU - Roach,Nancy, AU - Runowicz,Carolyn, AU - Saslow,Debbie, PY - 2004/2/3/pubmed PY - 2004/3/9/medline PY - 2004/2/3/entrez SP - 304 EP - 9 JF - Obstetrics and gynecology JO - Obstet Gynecol VL - 103 IS - 2 N2 - Human papillomavirus (HPV) DNA testing was recently approved by the Food and Drug Administration for use as an adjunct to cytology for cervical cancer screening. To help provide guidance to clinicians and patients when using HPV DNA testing as an adjunct to cervical cytology for screening, a workshop was cosponsored by the National Institutes of Health-National Cancer Institute, American Society of Colposcopy and Cervical Pathology (ASCCP), and American Cancer Society. Consensus was reached based on a literature review, expert opinion, and unpublished results from large ongoing screening studies. The conclusions of the workshop were that HPV DNA testing may be added to cervical cytology for screening in women aged 30 years or more. Women whose results are negative by both HPV DNA testing and cytology should not be rescreened before 3 years. Women whose results are negative by cytology, but are high-risk HPV DNA positive, are at a relatively low risk of having high-grade cervical neoplasia, and colposcopy should not be performed routinely in this setting. Instead, HPV DNA testing along with cervical cytology should be repeated in these women at 6 to 12 months. If test results of either are abnormal, colposcopy should then be performed. This guidance should assist clinicians in utilizing HPV DNA testing in an effective manner, while minimizing unnecessary evaluations and treatments. SN - 0029-7844 UR - https://www.unboundmedicine.com/medline/citation/14754700/Interim_guidance_for_the_use_of_human_papillomavirus_DNA_testing_as_an_adjunct_to_cervical_cytology_for_screening_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=14754700.ui DB - PRIME DP - Unbound Medicine ER -