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Concentration of insulin-like growth factor (IGF)-I in iliac crest bone matrix in premenopausal women with idiopathic osteoporosis.
Exp Clin Endocrinol Diabetes. 2004 Jan; 112(1):38-43.EC

Abstract

Previous studies have shown a link between low serum insulin-like growth factor-I (IGF-I) and decreased bone mass of patients with osteoporosis. However, whether serum levels are representative for the growth factor concentration or activity available in human bone tissue is controversial. In the present study, IGF-I was assessed in serum and bone matrix extracts from the iliac crest in 19 eugonadal women with idiopathic osteoporosis and in 38 age-matched controls. In addition, the relationship between the skeletal levels of IGF-I and bone mineral density (BMD) or the susceptibility to osteoporotic fractures in women with osteoporosis was examined. Bone matrix extraction was performed based on a guanidine-HCL/ethylendiamine-tetraacetic acid (EDTA) method. No significant difference in both serum and bone matrix IGF-I levels between groups was observed. Serum IGF-I concentrations failed to be associated with bone matrix IGF-I levels in osteoporotic patients. However, in premenopausal women with idiopathic osteoporosis, skeletal IGF-I positively correlated with BMD at the lumbar spine (r = + 0.58, p = 0.01). In contrast, neither femoral neck BMD nor Ward's triangle BMD was associated with bone matrix IGF-I concentrations. A tendency towards lower levels of bone matrix IGF-I in subjects with vertebral fractures as compared to those without fractures was observed in age-adjusted analyses, however the difference failed to remain statistically significant after adjustment for bone mineral density. These data provide no clear evidence for low bone matrix IGF-I as a determinant factor of age-unrelated osteoporosis. However, low skeletal IGF-I concentrations may aggravate osteoporosis in these women.

Authors+Show Affiliations

Department of Internal Medicine I, University of Heidelberg, Germany. carmenpepene@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14758570

Citation

Pepene, C E., et al. "Concentration of Insulin-like Growth Factor (IGF)-I in Iliac Crest Bone Matrix in Premenopausal Women With Idiopathic Osteoporosis." Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, vol. 112, no. 1, 2004, pp. 38-43.
Pepene CE, Seck T, Diel I, et al. Concentration of insulin-like growth factor (IGF)-I in iliac crest bone matrix in premenopausal women with idiopathic osteoporosis. Exp Clin Endocrinol Diabetes. 2004;112(1):38-43.
Pepene, C. E., Seck, T., Diel, I., Minne, H. W., Ziegler, R., & Pfeilschifter, J. (2004). Concentration of insulin-like growth factor (IGF)-I in iliac crest bone matrix in premenopausal women with idiopathic osteoporosis. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 112(1), 38-43.
Pepene CE, et al. Concentration of Insulin-like Growth Factor (IGF)-I in Iliac Crest Bone Matrix in Premenopausal Women With Idiopathic Osteoporosis. Exp Clin Endocrinol Diabetes. 2004;112(1):38-43. PubMed PMID: 14758570.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Concentration of insulin-like growth factor (IGF)-I in iliac crest bone matrix in premenopausal women with idiopathic osteoporosis. AU - Pepene,C E, AU - Seck,T, AU - Diel,I, AU - Minne,H W, AU - Ziegler,R, AU - Pfeilschifter,J, PY - 2004/2/6/pubmed PY - 2004/9/24/medline PY - 2004/2/6/entrez SP - 38 EP - 43 JF - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JO - Exp Clin Endocrinol Diabetes VL - 112 IS - 1 N2 - Previous studies have shown a link between low serum insulin-like growth factor-I (IGF-I) and decreased bone mass of patients with osteoporosis. However, whether serum levels are representative for the growth factor concentration or activity available in human bone tissue is controversial. In the present study, IGF-I was assessed in serum and bone matrix extracts from the iliac crest in 19 eugonadal women with idiopathic osteoporosis and in 38 age-matched controls. In addition, the relationship between the skeletal levels of IGF-I and bone mineral density (BMD) or the susceptibility to osteoporotic fractures in women with osteoporosis was examined. Bone matrix extraction was performed based on a guanidine-HCL/ethylendiamine-tetraacetic acid (EDTA) method. No significant difference in both serum and bone matrix IGF-I levels between groups was observed. Serum IGF-I concentrations failed to be associated with bone matrix IGF-I levels in osteoporotic patients. However, in premenopausal women with idiopathic osteoporosis, skeletal IGF-I positively correlated with BMD at the lumbar spine (r = + 0.58, p = 0.01). In contrast, neither femoral neck BMD nor Ward's triangle BMD was associated with bone matrix IGF-I concentrations. A tendency towards lower levels of bone matrix IGF-I in subjects with vertebral fractures as compared to those without fractures was observed in age-adjusted analyses, however the difference failed to remain statistically significant after adjustment for bone mineral density. These data provide no clear evidence for low bone matrix IGF-I as a determinant factor of age-unrelated osteoporosis. However, low skeletal IGF-I concentrations may aggravate osteoporosis in these women. SN - 0947-7349 UR - https://www.unboundmedicine.com/medline/citation/14758570/Concentration_of_insulin_like_growth_factor__IGF__I_in_iliac_crest_bone_matrix_in_premenopausal_women_with_idiopathic_osteoporosis_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2004-815725 DB - PRIME DP - Unbound Medicine ER -