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Angiotensin-converting enzyme and alpha-2-macroglobulin gene polymorphisms are not associated with Alzheimer's disease in Colombian patients.
J Neurol Sci 2004; 218(1-2):47-51JN

Abstract

Polymorphisms in alpha-2-macroglobulin (A2M) and angiotensin-converting enzyme (ACE) genes have been considered as risk factors for Alzheimer's disease (AD) independently of the risk conferred by the apolipoprotein E sigma4 allele (APOEsigma4) in diverse populations. In the present study, we have analysed the distribution of genotypes and alleles of the insertion/deletion (I/D) polymorphisms of ACE and A2M in 83 AD patients and 69 normal controls in Colombia. Our results showed that there is no association between the I/D polymorphisms of ACE and A2M with AD (P = 0.788 and P = 0.538, respectively). Using logistic regression and multiple correlation analysis (MCA), we confirmed that the main risk factor associated and consistently grouped with AD patients in this population is APOE4, but this association was not observed with alleles and genotypes of ACE and A2M.

Authors+Show Affiliations

Instituto de Genética, Universidad Nacional de Colombia, Calle 53 Carrera 30 Ciudad Universitaria, Bogotá, Colombia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14759632

Citation

Camelo, Dalila, et al. "Angiotensin-converting Enzyme and Alpha-2-macroglobulin Gene Polymorphisms Are Not Associated With Alzheimer's Disease in Colombian Patients." Journal of the Neurological Sciences, vol. 218, no. 1-2, 2004, pp. 47-51.
Camelo D, Arboleda G, Yunis JJ, et al. Angiotensin-converting enzyme and alpha-2-macroglobulin gene polymorphisms are not associated with Alzheimer's disease in Colombian patients. J Neurol Sci. 2004;218(1-2):47-51.
Camelo, D., Arboleda, G., Yunis, J. J., Pardo, R., Arango, G., Solano, E., ... Arboleda, H. (2004). Angiotensin-converting enzyme and alpha-2-macroglobulin gene polymorphisms are not associated with Alzheimer's disease in Colombian patients. Journal of the Neurological Sciences, 218(1-2), pp. 47-51.
Camelo D, et al. Angiotensin-converting Enzyme and Alpha-2-macroglobulin Gene Polymorphisms Are Not Associated With Alzheimer's Disease in Colombian Patients. J Neurol Sci. 2004 Mar 15;218(1-2):47-51. PubMed PMID: 14759632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiotensin-converting enzyme and alpha-2-macroglobulin gene polymorphisms are not associated with Alzheimer's disease in Colombian patients. AU - Camelo,Dalila, AU - Arboleda,Gonzalo, AU - Yunis,Juan J, AU - Pardo,Rodrigo, AU - Arango,Gabriel, AU - Solano,Eugenia, AU - López,Luis, AU - Hedmont,Daniel, AU - Arboleda,Humberto, PY - 2003/04/07/received PY - 2003/10/20/revised PY - 2003/10/21/accepted PY - 2004/2/5/pubmed PY - 2004/4/6/medline PY - 2004/2/5/entrez SP - 47 EP - 51 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 218 IS - 1-2 N2 - Polymorphisms in alpha-2-macroglobulin (A2M) and angiotensin-converting enzyme (ACE) genes have been considered as risk factors for Alzheimer's disease (AD) independently of the risk conferred by the apolipoprotein E sigma4 allele (APOEsigma4) in diverse populations. In the present study, we have analysed the distribution of genotypes and alleles of the insertion/deletion (I/D) polymorphisms of ACE and A2M in 83 AD patients and 69 normal controls in Colombia. Our results showed that there is no association between the I/D polymorphisms of ACE and A2M with AD (P = 0.788 and P = 0.538, respectively). Using logistic regression and multiple correlation analysis (MCA), we confirmed that the main risk factor associated and consistently grouped with AD patients in this population is APOE4, but this association was not observed with alleles and genotypes of ACE and A2M. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/14759632/Angiotensin_converting_enzyme_and_alpha_2_macroglobulin_gene_polymorphisms_are_not_associated_with_Alzheimer's_disease_in_Colombian_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022510X03003241 DB - PRIME DP - Unbound Medicine ER -