Tags

Type your tag names separated by a space and hit enter

Age, adherence and injection drug use predict virological suppression among men and women enrolled in a population-based antiretroviral drug treatment programme.
Antivir Ther. 2003 Dec; 8(6):569-76.AT

Abstract

OBJECTIVES

To characterize 1-year virological response to antiretroviral therapy and its determinants by sex.

METHODS

This is a population-based analysis of antiretroviral therapy naive HIV-positive adult men and women. Factors associated with sex and with plasma HIV RNA viral load suppression to below 500 copies/ml were examined using non-parametric tests and logistic regression analyses.

RESULTS

A total of 739 subjects (92 women and 647 men) were eligible. Female participants were younger (34 vs 37 years; P < 0.001), less likely to have AIDS (6.5 vs 14.4%; P = 0.039), more frequently injection drug users (44.6 vs 25.2%; P = 0.001) and were less likely to be adherent to therapy (34.8 vs 62.9%; P < 0.001) than male participants. There was no difference in baseline median CD4 count (P = 0.424) or HIV RNA levels (P = 0.140), physician experience (P = 0.057), or with respect to antiretroviral regimens containing protease inhibitors or non-nucleoside reverse transcriptase inhibitors (P = 0.911). With treatment, 46.7% (43/92) of women and 64.8% (419/647) of men (P = 0.001) suppressed HIV RNA viral load to below 500 copies/ml at 1 year. In a multivariate analysis, the association of sex with HIV RNA response to antiretroviral therapy fell from statistical significance (odds ratio 1.18; 95% CI: 0.72-1.95) after adjusting for adherence, injection drug use and age.

CONCLUSION

Our data indicate that in this population-based setting, sex differences in 1-year virological response to antiretroviral therapy are explained by age, adherence and injection drug use.

Authors+Show Affiliations

BC Centre for Excellence in HIV/AIDS, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14760890

Citation

O'Connell, Jacqueline M., et al. "Age, Adherence and Injection Drug Use Predict Virological Suppression Among Men and Women Enrolled in a Population-based Antiretroviral Drug Treatment Programme." Antiviral Therapy, vol. 8, no. 6, 2003, pp. 569-76.
O'Connell JM, Braitstein P, Hogg RS, et al. Age, adherence and injection drug use predict virological suppression among men and women enrolled in a population-based antiretroviral drug treatment programme. Antivir Ther (Lond). 2003;8(6):569-76.
O'Connell, J. M., Braitstein, P., Hogg, R. S., Yip, B., Craib, K. J., O'Shaughnessy, M. V., Montaner, J. S., & Burdge, D. R. (2003). Age, adherence and injection drug use predict virological suppression among men and women enrolled in a population-based antiretroviral drug treatment programme. Antiviral Therapy, 8(6), 569-76.
O'Connell JM, et al. Age, Adherence and Injection Drug Use Predict Virological Suppression Among Men and Women Enrolled in a Population-based Antiretroviral Drug Treatment Programme. Antivir Ther (Lond). 2003;8(6):569-76. PubMed PMID: 14760890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age, adherence and injection drug use predict virological suppression among men and women enrolled in a population-based antiretroviral drug treatment programme. AU - O'Connell,Jacqueline M, AU - Braitstein,Paula, AU - Hogg,Robert S, AU - Yip,Benito, AU - Craib,Kevin J P, AU - O'Shaughnessy,Michael V, AU - Montaner,Julio S G, AU - Burdge,David R, PY - 2004/2/6/pubmed PY - 2004/3/10/medline PY - 2004/2/6/entrez SP - 569 EP - 76 JF - Antiviral therapy JO - Antivir. Ther. (Lond.) VL - 8 IS - 6 N2 - OBJECTIVES: To characterize 1-year virological response to antiretroviral therapy and its determinants by sex. METHODS: This is a population-based analysis of antiretroviral therapy naive HIV-positive adult men and women. Factors associated with sex and with plasma HIV RNA viral load suppression to below 500 copies/ml were examined using non-parametric tests and logistic regression analyses. RESULTS: A total of 739 subjects (92 women and 647 men) were eligible. Female participants were younger (34 vs 37 years; P < 0.001), less likely to have AIDS (6.5 vs 14.4%; P = 0.039), more frequently injection drug users (44.6 vs 25.2%; P = 0.001) and were less likely to be adherent to therapy (34.8 vs 62.9%; P < 0.001) than male participants. There was no difference in baseline median CD4 count (P = 0.424) or HIV RNA levels (P = 0.140), physician experience (P = 0.057), or with respect to antiretroviral regimens containing protease inhibitors or non-nucleoside reverse transcriptase inhibitors (P = 0.911). With treatment, 46.7% (43/92) of women and 64.8% (419/647) of men (P = 0.001) suppressed HIV RNA viral load to below 500 copies/ml at 1 year. In a multivariate analysis, the association of sex with HIV RNA response to antiretroviral therapy fell from statistical significance (odds ratio 1.18; 95% CI: 0.72-1.95) after adjusting for adherence, injection drug use and age. CONCLUSION: Our data indicate that in this population-based setting, sex differences in 1-year virological response to antiretroviral therapy are explained by age, adherence and injection drug use. SN - 1359-6535 UR - https://www.unboundmedicine.com/medline/citation/14760890/Age_adherence_and_injection_drug_use_predict_virological_suppression_among_men_and_women_enrolled_in_a_population_based_antiretroviral_drug_treatment_programme_ L2 - http://hivinsite.ucsf.edu/InSite?page=kb-03-02-09 DB - PRIME DP - Unbound Medicine ER -