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Mechanisms involved in peripheral nerve damage in leprosy with special reference to insights obtained from in vitro studies and the experimental mouse model.
Int J Lepr Other Mycobact Dis. 2003 Dec; 71(4):345-54.IJ

Abstract

The histopathological observations of Khanolkar and Iyer, that M. leprae has a predeliction for nerves, first highlighted the central role of peripheral nerves in the pathology of leprosy. It is now well recognized that nerve damage in leprosy will still continue to be an important problem in control and rehabilitation despite the presence of more efficient therapy. The multiplicity of mechanisms postulated, identified, and demonstrated in the last three decades has received little recognition from the scientific community at large. This review is therefore an attempt to collate these multiple studies on mechanisms of nerve damage into a cohesive analysis, which would facilitate the design of future studies. The objective of this review is to focus therefore only on studies which serve to illustrate mechanisms of nerve damage.

Authors+Show Affiliations

The Foundation For Medical Research, 84-A, RG Thadani Marg, Worli, Mumbai 400 0018. frchbom@bom2.vsnl.net.inNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

14763884

Citation

Birdi, Tannaz J., and Noshir H. Antia. "Mechanisms Involved in Peripheral Nerve Damage in Leprosy With Special Reference to Insights Obtained From in Vitro Studies and the Experimental Mouse Model." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 71, no. 4, 2003, pp. 345-54.
Birdi TJ, Antia NH. Mechanisms involved in peripheral nerve damage in leprosy with special reference to insights obtained from in vitro studies and the experimental mouse model. Int J Lepr Other Mycobact Dis. 2003;71(4):345-54.
Birdi, T. J., & Antia, N. H. (2003). Mechanisms involved in peripheral nerve damage in leprosy with special reference to insights obtained from in vitro studies and the experimental mouse model. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 71(4), 345-54.
Birdi TJ, Antia NH. Mechanisms Involved in Peripheral Nerve Damage in Leprosy With Special Reference to Insights Obtained From in Vitro Studies and the Experimental Mouse Model. Int J Lepr Other Mycobact Dis. 2003;71(4):345-54. PubMed PMID: 14763884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms involved in peripheral nerve damage in leprosy with special reference to insights obtained from in vitro studies and the experimental mouse model. AU - Birdi,Tannaz J, AU - Antia,Noshir H, PY - 2004/2/7/pubmed PY - 2004/3/26/medline PY - 2004/2/7/entrez SP - 345 EP - 54 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 71 IS - 4 N2 - The histopathological observations of Khanolkar and Iyer, that M. leprae has a predeliction for nerves, first highlighted the central role of peripheral nerves in the pathology of leprosy. It is now well recognized that nerve damage in leprosy will still continue to be an important problem in control and rehabilitation despite the presence of more efficient therapy. The multiplicity of mechanisms postulated, identified, and demonstrated in the last three decades has received little recognition from the scientific community at large. This review is therefore an attempt to collate these multiple studies on mechanisms of nerve damage into a cohesive analysis, which would facilitate the design of future studies. The objective of this review is to focus therefore only on studies which serve to illustrate mechanisms of nerve damage. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/14763884/Mechanisms_involved_in_peripheral_nerve_damage_in_leprosy_with_special_reference_to_insights_obtained_from_in_vitro_studies_and_the_experimental_mouse_model_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -