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Ultrastructural study of Schwann cells and endothelial cells in the pathogenesis of leprous neuropathy.
Int J Lepr Other Mycobact Dis. 2003 Dec; 71(4):328-40.IJ

Abstract

Peripheral nerve biopsies from 4 borderline tuberculoid (BT) and 4 lepromatous (LL) patients who were on multidrug therapy were investigated by light and electron microscopic studies. The variation of diameters and distribution of myelinated and unmyelinated fibers between BT and LL patients were not significant. This study has shown significant changes in peripheral nerves and endoneural blood vessels. It was revealed that besides Schwann cells (SC), the endothelial cells (EC) of endoneural blood vessels frequently harbor M. leprae. In BT, peripheral nerves in addition to the degenerative changes of SC and presence of perineural and perivascular cuffing by mononuclear cells, the endoneurial blood vessels showed thickening of basement membrane with hypertrophy of EC leading to narrowing or complete occlusion of lumen. On the other hand, peripheral nerves of LL patients were infiltrated with large number of M. leprae shown to be present in the electron transparent zone (ETZ) of the SC. The EC of endoneurial blood vessels were found to be loaded with M. leprae, and this bacillary loaded EC was found to release M. leprae into the lumen through its ruptured membrane.

Authors+Show Affiliations

Division of Immunology, Central JALMA Institute for Leprosy, Indian Council of Medical Research, Taj Ganj Agra-282001, India. vkjalma@yahoo.comNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

14763886

Citation

Kumar, V, and U Sengupta. "Ultrastructural Study of Schwann Cells and Endothelial Cells in the Pathogenesis of Leprous Neuropathy." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 71, no. 4, 2003, pp. 328-40.
Kumar V, Sengupta U. Ultrastructural study of Schwann cells and endothelial cells in the pathogenesis of leprous neuropathy. Int J Lepr Other Mycobact Dis. 2003;71(4):328-40.
Kumar, V., & Sengupta, U. (2003). Ultrastructural study of Schwann cells and endothelial cells in the pathogenesis of leprous neuropathy. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 71(4), 328-40.
Kumar V, Sengupta U. Ultrastructural Study of Schwann Cells and Endothelial Cells in the Pathogenesis of Leprous Neuropathy. Int J Lepr Other Mycobact Dis. 2003;71(4):328-40. PubMed PMID: 14763886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ultrastructural study of Schwann cells and endothelial cells in the pathogenesis of leprous neuropathy. AU - Kumar,V, AU - Sengupta,U, PY - 2004/2/7/pubmed PY - 2004/3/26/medline PY - 2004/2/7/entrez SP - 328 EP - 40 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 71 IS - 4 N2 - Peripheral nerve biopsies from 4 borderline tuberculoid (BT) and 4 lepromatous (LL) patients who were on multidrug therapy were investigated by light and electron microscopic studies. The variation of diameters and distribution of myelinated and unmyelinated fibers between BT and LL patients were not significant. This study has shown significant changes in peripheral nerves and endoneural blood vessels. It was revealed that besides Schwann cells (SC), the endothelial cells (EC) of endoneural blood vessels frequently harbor M. leprae. In BT, peripheral nerves in addition to the degenerative changes of SC and presence of perineural and perivascular cuffing by mononuclear cells, the endoneurial blood vessels showed thickening of basement membrane with hypertrophy of EC leading to narrowing or complete occlusion of lumen. On the other hand, peripheral nerves of LL patients were infiltrated with large number of M. leprae shown to be present in the electron transparent zone (ETZ) of the SC. The EC of endoneurial blood vessels were found to be loaded with M. leprae, and this bacillary loaded EC was found to release M. leprae into the lumen through its ruptured membrane. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/14763886/Ultrastructural_study_of_Schwann_cells_and_endothelial_cells_in_the_pathogenesis_of_leprous_neuropathy_ L2 - https://medlineplus.gov/peripheralnervedisorders.html DB - PRIME DP - Unbound Medicine ER -