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Warfarin and herbal products interaction causing prosthetic aortic valve thrombosis presenting as acute myocardial infarction.
J Heart Valve Dis. 2004 Jan; 13(1):22-4.JH

Abstract

Myocardial infarction (MI) due to coronary artery embolization is a rare and potentially lethal complication of prosthetic heart valve thrombosis. A 58-year-old man in whom the aortic valve was replaced with a bileaflet mechanical valve presented with an acute anterior MI. Valvular dysfunction was detected by physical examination, and confirmed by two-dimensional echocardiography and cinefluoroscopy. Coronary angiography disclosed embolization of the left anterior descending artery. Thrombotic encroachment of one of the prosthetic valve leaflets was found at reoperation. Failure to achieve adequate anticoagulation was likely due to an interaction between warfarin and herbal products. These findings have significant implications regarding the diagnosis and treatment of acute MI in patients with left-sided prosthetic heart valves, and emphasizes the importance of appropriate anticoagulation in this setting.

Authors+Show Affiliations

Mendoza CE
Division of Cardiology, Jackson Memorial Hospital, University of Miami School of Medicine, Miami, Florida 33136, USA. mendozatrauco@yahoo.com
Ferreira AC
No affiliation info available
de Marchena E
No affiliation info available

MeSH

AnticoagulantsAortic ValveHeart Valve DiseasesHeart Valve ProsthesisHerb-Drug InteractionsHumansMaleMiddle AgedMyocardial InfarctionPlants, MedicinalPostoperative ComplicationsThrombosisWarfarin

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

14765834

Citation

Mendoza, Cesar E., et al. "Warfarin and Herbal Products Interaction Causing Prosthetic Aortic Valve Thrombosis Presenting as Acute Myocardial Infarction." The Journal of Heart Valve Disease, vol. 13, no. 1, 2004, pp. 22-4.
Mendoza CE, Ferreira AC, de Marchena E. Warfarin and herbal products interaction causing prosthetic aortic valve thrombosis presenting as acute myocardial infarction. J Heart Valve Dis. 2004;13(1):22-4.
Mendoza, C. E., Ferreira, A. C., & de Marchena, E. (2004). Warfarin and herbal products interaction causing prosthetic aortic valve thrombosis presenting as acute myocardial infarction. The Journal of Heart Valve Disease, 13(1), 22-4.
Mendoza CE, Ferreira AC, de Marchena E. Warfarin and Herbal Products Interaction Causing Prosthetic Aortic Valve Thrombosis Presenting as Acute Myocardial Infarction. J Heart Valve Dis. 2004;13(1):22-4. PubMed PMID: 14765834.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Warfarin and herbal products interaction causing prosthetic aortic valve thrombosis presenting as acute myocardial infarction. AU - Mendoza,Cesar E, AU - Ferreira,Alexandre C, AU - de Marchena,Eduardo, PY - 2004/2/10/pubmed PY - 2004/9/3/medline PY - 2004/2/10/entrez SP - 22 EP - 4 JF - The Journal of heart valve disease JO - J Heart Valve Dis VL - 13 IS - 1 N2 - Myocardial infarction (MI) due to coronary artery embolization is a rare and potentially lethal complication of prosthetic heart valve thrombosis. A 58-year-old man in whom the aortic valve was replaced with a bileaflet mechanical valve presented with an acute anterior MI. Valvular dysfunction was detected by physical examination, and confirmed by two-dimensional echocardiography and cinefluoroscopy. Coronary angiography disclosed embolization of the left anterior descending artery. Thrombotic encroachment of one of the prosthetic valve leaflets was found at reoperation. Failure to achieve adequate anticoagulation was likely due to an interaction between warfarin and herbal products. These findings have significant implications regarding the diagnosis and treatment of acute MI in patients with left-sided prosthetic heart valves, and emphasizes the importance of appropriate anticoagulation in this setting. SN - 0966-8519 UR - https://www.unboundmedicine.com/medline/citation/14765834/Warfarin_and_herbal_products_interaction_causing_prosthetic_aortic_valve_thrombosis_presenting_as_acute_myocardial_infarction_ DB - PRIME DP - Unbound Medicine ER -