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Prognostic significance of stromal metalloproteinase-2 in ovarian adenocarcinoma and its relation to carcinoma progression.
Gynecol Oncol. 2004 Feb; 92(2):559-67.GO

Abstract

OBJECTIVES

MMP-2 expression in ovarian cancer cells has been correlated with poor prognosis. This study attempts to assess the prognostic importance of stromal MMP-2 in patients with ovarian endometrioid and serous adenocarcinoma.

METHODS

MMP-2, MMP-2 activator, MT1-MMP, and its inhibitor (TIMP-2) were immunostained in 84 primary epithelial ovarian carcinomas (EOCs) (35 endometrioid adenocarcinomas [ECs] and 49 serous adenocarcinomas [SCs]). Results were correlated to pathological subtypes, tumor stage, grade, size, and to recurrence-free and cancer-specific survival.

RESULTS

MMP-2 and stromal MMP-2 were detected in all carcinoma cells of 22.2% of EC and 77.8% of SC tumors. MT1-MMP co-localized with MMP-2. TIMP-2 staining was weak and cytoplasmically distributed in all tumors. Univariant analysis showed expression of stromal MMP-2 significantly associated with advanced stage (P = 0.018), higher grade (P = 0.005), serous subtype (P = 0.02), smaller tumor size at operation (P = 0.001), and higher incidence of recurrence (P = 0.042), but not with the rate of death due to cancer. By multiple Cox proportional hazard regression analysis, patient survival and disease-free survival were significantly related to the presence of stromal MMP-2 in EC but not SC patients (P < 0.05). However, after multivariant analysis, the associations with patient age, tumor stage, grade, and size no longer existed. In stepwise selection, tumor stage remained the most important predictor of patient survival and disease-free survival in ovarian EC and SC, but stromal MMP-2 remained the most important predictor of recurrence-free survival in patients with EC.

CONCLUSIONS

Stromal MMP-2 occurs early and may play a role early in EOC invasion. Tumor stage and stromal MMP-2 are important predictors of disease-free survival.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. ctl@ha.mc.ntu.edu.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14766248

Citation

Torng, Pao-Ling, et al. "Prognostic Significance of Stromal Metalloproteinase-2 in Ovarian Adenocarcinoma and Its Relation to Carcinoma Progression." Gynecologic Oncology, vol. 92, no. 2, 2004, pp. 559-67.
Torng PL, Mao TL, Chan WY, et al. Prognostic significance of stromal metalloproteinase-2 in ovarian adenocarcinoma and its relation to carcinoma progression. Gynecol Oncol. 2004;92(2):559-67.
Torng, P. L., Mao, T. L., Chan, W. Y., Huang, S. C., & Lin, C. T. (2004). Prognostic significance of stromal metalloproteinase-2 in ovarian adenocarcinoma and its relation to carcinoma progression. Gynecologic Oncology, 92(2), 559-67.
Torng PL, et al. Prognostic Significance of Stromal Metalloproteinase-2 in Ovarian Adenocarcinoma and Its Relation to Carcinoma Progression. Gynecol Oncol. 2004;92(2):559-67. PubMed PMID: 14766248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prognostic significance of stromal metalloproteinase-2 in ovarian adenocarcinoma and its relation to carcinoma progression. AU - Torng,Pao-Ling, AU - Mao,Tsui-Lien, AU - Chan,Wing-Yee, AU - Huang,Su-Cheng, AU - Lin,Chin-Tang, PY - 2003/09/03/received PY - 2004/2/10/pubmed PY - 2004/3/24/medline PY - 2004/2/10/entrez SP - 559 EP - 67 JF - Gynecologic oncology JO - Gynecol Oncol VL - 92 IS - 2 N2 - OBJECTIVES: MMP-2 expression in ovarian cancer cells has been correlated with poor prognosis. This study attempts to assess the prognostic importance of stromal MMP-2 in patients with ovarian endometrioid and serous adenocarcinoma. METHODS: MMP-2, MMP-2 activator, MT1-MMP, and its inhibitor (TIMP-2) were immunostained in 84 primary epithelial ovarian carcinomas (EOCs) (35 endometrioid adenocarcinomas [ECs] and 49 serous adenocarcinomas [SCs]). Results were correlated to pathological subtypes, tumor stage, grade, size, and to recurrence-free and cancer-specific survival. RESULTS: MMP-2 and stromal MMP-2 were detected in all carcinoma cells of 22.2% of EC and 77.8% of SC tumors. MT1-MMP co-localized with MMP-2. TIMP-2 staining was weak and cytoplasmically distributed in all tumors. Univariant analysis showed expression of stromal MMP-2 significantly associated with advanced stage (P = 0.018), higher grade (P = 0.005), serous subtype (P = 0.02), smaller tumor size at operation (P = 0.001), and higher incidence of recurrence (P = 0.042), but not with the rate of death due to cancer. By multiple Cox proportional hazard regression analysis, patient survival and disease-free survival were significantly related to the presence of stromal MMP-2 in EC but not SC patients (P < 0.05). However, after multivariant analysis, the associations with patient age, tumor stage, grade, and size no longer existed. In stepwise selection, tumor stage remained the most important predictor of patient survival and disease-free survival in ovarian EC and SC, but stromal MMP-2 remained the most important predictor of recurrence-free survival in patients with EC. CONCLUSIONS: Stromal MMP-2 occurs early and may play a role early in EOC invasion. Tumor stage and stromal MMP-2 are important predictors of disease-free survival. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/14766248/Prognostic_significance_of_stromal_metalloproteinase_2_in_ovarian_adenocarcinoma_and_its_relation_to_carcinoma_progression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090825803007935 DB - PRIME DP - Unbound Medicine ER -