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Primary Ewing's sarcoma-primitive neuroectodermal tumor of the vagina.
Gynecol Oncol. 2004 Feb; 92(2):684-8.GO

Abstract

BACKGROUND

Only three cases of Ewing's sarcoma-primitive neuroectodermal tumor (ES-PNET) occurring in the vagina have been previously reported.

CASE

A 30-year-old Chinese woman presented with a vaginal mass measuring 5 cm in greatest dimension. The tumor was composed of solid sheets of undifferentiated small round cells with numerous Homer-Wright rosettes. Immunohistochemically, it was positive for CD99, FlI-1 protein, synaptophysin, neuron-specific enolase, vimentin, and S-100 protein. The patient underwent wide local excision of the tumor and subsequent total abdominal hysterectomy with postoperative chemotherapy and radiotherapy. She is disease-free 36 months after the initial surgery.

CONCLUSION

This is a rare case of ES-PNET occurring in the vagina and the first showing many distinctive Homer-Wright rosettes. A review of literature indicates that vaginal or vulvar ES-PNET affects younger women, and it may have a relatively favorable outcome.

Authors+Show Affiliations

Department of Pathology, Peking University People's Hospital, Beijing 100044, PR China. xiaoyliao@sina.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

14766267

Citation

Liao, Xiaoyun, et al. "Primary Ewing's Sarcoma-primitive Neuroectodermal Tumor of the Vagina." Gynecologic Oncology, vol. 92, no. 2, 2004, pp. 684-8.
Liao X, Xin X, Lü X. Primary Ewing's sarcoma-primitive neuroectodermal tumor of the vagina. Gynecol Oncol. 2004;92(2):684-8.
Liao, X., Xin, X., & Lü, X. (2004). Primary Ewing's sarcoma-primitive neuroectodermal tumor of the vagina. Gynecologic Oncology, 92(2), 684-8.
Liao X, Xin X, Lü X. Primary Ewing's Sarcoma-primitive Neuroectodermal Tumor of the Vagina. Gynecol Oncol. 2004;92(2):684-8. PubMed PMID: 14766267.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary Ewing's sarcoma-primitive neuroectodermal tumor of the vagina. AU - Liao,Xiaoyun, AU - Xin,Xiuxia, AU - Lü,Xiaohong, PY - 2002/12/18/received PY - 2004/2/10/pubmed PY - 2004/3/24/medline PY - 2004/2/10/entrez SP - 684 EP - 8 JF - Gynecologic oncology JO - Gynecol. Oncol. VL - 92 IS - 2 N2 - BACKGROUND: Only three cases of Ewing's sarcoma-primitive neuroectodermal tumor (ES-PNET) occurring in the vagina have been previously reported. CASE: A 30-year-old Chinese woman presented with a vaginal mass measuring 5 cm in greatest dimension. The tumor was composed of solid sheets of undifferentiated small round cells with numerous Homer-Wright rosettes. Immunohistochemically, it was positive for CD99, FlI-1 protein, synaptophysin, neuron-specific enolase, vimentin, and S-100 protein. The patient underwent wide local excision of the tumor and subsequent total abdominal hysterectomy with postoperative chemotherapy and radiotherapy. She is disease-free 36 months after the initial surgery. CONCLUSION: This is a rare case of ES-PNET occurring in the vagina and the first showing many distinctive Homer-Wright rosettes. A review of literature indicates that vaginal or vulvar ES-PNET affects younger women, and it may have a relatively favorable outcome. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/14766267/Primary_Ewing's_sarcoma_primitive_neuroectodermal_tumor_of_the_vagina_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090825803007650 DB - PRIME DP - Unbound Medicine ER -