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Diphenylcyclopropenone (diphencyprone, DPCP) in the treatment of chronic severe alopecia areata (AA).
Eur Ann Allergy Clin Immunol. 2003 Dec; 35(10):397-401.EA

Abstract

BACKGROUND

Diphenylcyclopropenone (DPCP) has been reported to be an effective topical immunotherapy of extensive alopecia areata (AA) with highly variable reported results.

OBJECTIVE

The purposes of this study were to assess the efficacy, side effects, and adverse prognostic factors in the treatment of alopecia areata with DPCP.

METHODS

21 patients were included in the study with chronic and extensive AA. Patients were sensitized in the beginning with 2% DPCP, and the concentrations were increased gradually beginning with 0.000001% every one to two weeks for a period of 6 months.

RESULTS

15 patients (71.4%) had a complete or partial recovery at the end of the treatment period. Most frequent side effects were erythema at the site of application, pigmentation, and lymph node enlargement. The most important adverse prognostic factors were duration of AA, history of atopy, and presence of nail changes.

CONCLUSION

Treatment of AA with topical DPCP is effective. Though the treatment may have some side effects, in most cases they are tolerable and respond well to treatment.

Authors+Show Affiliations

Faculty of Medicine and Health Sciences, UAE University, Dermatology Department, Al-Ain Hospital, Al-Ain, UAE.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

14768526

Citation

Galadari, I, et al. "Diphenylcyclopropenone (diphencyprone, DPCP) in the Treatment of Chronic Severe Alopecia Areata (AA)." European Annals of Allergy and Clinical Immunology, vol. 35, no. 10, 2003, pp. 397-401.
Galadari I, Rubaie S, Alkaabi J, et al. Diphenylcyclopropenone (diphencyprone, DPCP) in the treatment of chronic severe alopecia areata (AA). Eur Ann Allergy Clin Immunol. 2003;35(10):397-401.
Galadari, I., Rubaie, S., Alkaabi, J., & Galadari, H. (2003). Diphenylcyclopropenone (diphencyprone, DPCP) in the treatment of chronic severe alopecia areata (AA). European Annals of Allergy and Clinical Immunology, 35(10), 397-401.
Galadari I, et al. Diphenylcyclopropenone (diphencyprone, DPCP) in the Treatment of Chronic Severe Alopecia Areata (AA). Eur Ann Allergy Clin Immunol. 2003;35(10):397-401. PubMed PMID: 14768526.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diphenylcyclopropenone (diphencyprone, DPCP) in the treatment of chronic severe alopecia areata (AA). AU - Galadari,I, AU - Rubaie,S, AU - Alkaabi,J, AU - Galadari,H, PY - 2004/2/11/pubmed PY - 2004/3/27/medline PY - 2004/2/11/entrez SP - 397 EP - 401 JF - European annals of allergy and clinical immunology JO - Eur Ann Allergy Clin Immunol VL - 35 IS - 10 N2 - BACKGROUND: Diphenylcyclopropenone (DPCP) has been reported to be an effective topical immunotherapy of extensive alopecia areata (AA) with highly variable reported results. OBJECTIVE: The purposes of this study were to assess the efficacy, side effects, and adverse prognostic factors in the treatment of alopecia areata with DPCP. METHODS: 21 patients were included in the study with chronic and extensive AA. Patients were sensitized in the beginning with 2% DPCP, and the concentrations were increased gradually beginning with 0.000001% every one to two weeks for a period of 6 months. RESULTS: 15 patients (71.4%) had a complete or partial recovery at the end of the treatment period. Most frequent side effects were erythema at the site of application, pigmentation, and lymph node enlargement. The most important adverse prognostic factors were duration of AA, history of atopy, and presence of nail changes. CONCLUSION: Treatment of AA with topical DPCP is effective. Though the treatment may have some side effects, in most cases they are tolerable and respond well to treatment. SN - 1764-1489 UR - https://www.unboundmedicine.com/medline/citation/14768526/Diphenylcyclopropenone__diphencyprone_DPCP__in_the_treatment_of_chronic_severe_alopecia_areata__AA__ L2 - https://www.diseaseinfosearch.org/result/313 DB - PRIME DP - Unbound Medicine ER -