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Relation between upregulation of CD40 system and complex stenosis morphology in patients with acute coronary syndrome.
Acta Pharmacol Sin 2004; 25(2):251-6AP

Abstract

AIM

To investigate whether upregulation of CD40-CD40 ligand system is related to matrix metalloproteinases level and stability of coronary atherosclerotic plaque in patients with acute coronary syndrome (ACS).

METHODS

Sixteen normal controls and 56 patients including 24 with stable angina (SA), 20 with unstable angina (UA), and 12 with acute myocardial infarction (AMI) were investigated. The expression of CD40 and CD40L on platelet was analyzed by flow cytometry. Serum soluble CD40L (sCD40L), MMP-9 and MMP-3 level was determined by ELISA. All coronary stenosis with > or =30% diameter reduction were assessed by angiographic coronary stenosis morphology.

RESULTS

Patients with ACS showed a significant increase of CD40 (75 +/- 12 MIF) and CD40L (13 +/- 4 MIF) coexpression on platelets compared with control and SA group (P<0.01). sCD40L also showed higher level in patients with ACS (10.2 +/- 3.5 microg/L) than in control (3.1 +/- 1.4 microg/L, P<0.01) and SA group (3.3 +/- 1.6 microg/L, P<0.01). Serum MMP-3 and MMP-9 in patients with ACS were two times greater than those in control. A positive correlation was found between MMP-9, MMP-3, and CD40L expression on platelets as well as sCD40L levels, but not for CD40 expression on platelets. An obvious correlation was also observed between sCD40L concentration and complex coronary stenoses (r=0.60, P<0.01).

CONCLUSION

Patients with ACS show increased coexpression of CD40 system, especially expression of CD40L, which may create a proinflammatory and prothrombotic milieu for aggravating the development of atherosclerosis and instability of atherosclerotic plaques, and may be a valuable marker for predicting the severity of ACS.

Authors+Show Affiliations

Department of Cardiology, Affiliated Zhong Da Hospital, Southeast University, Nanjing 210009, China. yanjinchuan@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14769218

Citation

Yan, Jin-chuan, et al. "Relation Between Upregulation of CD40 System and Complex Stenosis Morphology in Patients With Acute Coronary Syndrome." Acta Pharmacologica Sinica, vol. 25, no. 2, 2004, pp. 251-6.
Yan JC, Wu ZG, Kong XT, et al. Relation between upregulation of CD40 system and complex stenosis morphology in patients with acute coronary syndrome. Acta Pharmacol Sin. 2004;25(2):251-6.
Yan, J. C., Wu, Z. G., Kong, X. T., Zong, R. Q., & Zhan, L. Z. (2004). Relation between upregulation of CD40 system and complex stenosis morphology in patients with acute coronary syndrome. Acta Pharmacologica Sinica, 25(2), pp. 251-6.
Yan JC, et al. Relation Between Upregulation of CD40 System and Complex Stenosis Morphology in Patients With Acute Coronary Syndrome. Acta Pharmacol Sin. 2004;25(2):251-6. PubMed PMID: 14769218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relation between upregulation of CD40 system and complex stenosis morphology in patients with acute coronary syndrome. AU - Yan,Jin-chuan, AU - Wu,Zong-gui, AU - Kong,Xian-tao, AU - Zong,Ren-qian, AU - Zhan,Lin-zen, PY - 2004/2/11/pubmed PY - 2004/7/31/medline PY - 2004/2/11/entrez SP - 251 EP - 6 JF - Acta pharmacologica Sinica JO - Acta Pharmacol. Sin. VL - 25 IS - 2 N2 - AIM: To investigate whether upregulation of CD40-CD40 ligand system is related to matrix metalloproteinases level and stability of coronary atherosclerotic plaque in patients with acute coronary syndrome (ACS). METHODS: Sixteen normal controls and 56 patients including 24 with stable angina (SA), 20 with unstable angina (UA), and 12 with acute myocardial infarction (AMI) were investigated. The expression of CD40 and CD40L on platelet was analyzed by flow cytometry. Serum soluble CD40L (sCD40L), MMP-9 and MMP-3 level was determined by ELISA. All coronary stenosis with > or =30% diameter reduction were assessed by angiographic coronary stenosis morphology. RESULTS: Patients with ACS showed a significant increase of CD40 (75 +/- 12 MIF) and CD40L (13 +/- 4 MIF) coexpression on platelets compared with control and SA group (P<0.01). sCD40L also showed higher level in patients with ACS (10.2 +/- 3.5 microg/L) than in control (3.1 +/- 1.4 microg/L, P<0.01) and SA group (3.3 +/- 1.6 microg/L, P<0.01). Serum MMP-3 and MMP-9 in patients with ACS were two times greater than those in control. A positive correlation was found between MMP-9, MMP-3, and CD40L expression on platelets as well as sCD40L levels, but not for CD40 expression on platelets. An obvious correlation was also observed between sCD40L concentration and complex coronary stenoses (r=0.60, P<0.01). CONCLUSION: Patients with ACS show increased coexpression of CD40 system, especially expression of CD40L, which may create a proinflammatory and prothrombotic milieu for aggravating the development of atherosclerosis and instability of atherosclerotic plaques, and may be a valuable marker for predicting the severity of ACS. SN - 1671-4083 UR - https://www.unboundmedicine.com/medline/citation/14769218/Relation_between_upregulation_of_CD40_system_and_complex_stenosis_morphology_in_patients_with_acute_coronary_syndrome_ L2 - http://www.chinaphar.com/1671-4083/25/251.pdf DB - PRIME DP - Unbound Medicine ER -