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Development and biopharmaceutical evaluation of osmotic pump tablets for controlled delivery of diclofenac sodium.
Acta Pharm. 2003 Dec; 53(4):263-73.AP

Abstract

Based on the principles of an elementary osmotic pump (OP), OP tablets were designed and evaluated with the aim to deliver diclofenac sodium (DS) in a controlled manner. In vitro evaluation was done in various release media and kinetics was evaluated using the regression coefficient analysis. Effects of orifice size, coating membrane type, coating thickness, static and stirred conditions and pH variation were studied. In vivo evaluation was performed on six healthy human volunteers and various pharmacokinetic parameters (c(max), t(max), AUC(0-24), MRT) and relative bioavailability were calculated. The results were compared with the performance of two commercial tablets of DS. The drug release from OP tablets was dependent on the type and thickness of the coating membrane, but was independent of the orifice size and static and stirred conditions of the release medium. The OP tablets provided a prolonged and controlled DS release compared to commercial sustained-release and conventional tablets of DS.

Authors+Show Affiliations

Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005 (U.P.), India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

14769233

Citation

Rani, Meena, et al. "Development and Biopharmaceutical Evaluation of Osmotic Pump Tablets for Controlled Delivery of Diclofenac Sodium." Acta Pharmaceutica (Zagreb, Croatia), vol. 53, no. 4, 2003, pp. 263-73.
Rani M, Surana R, Sankar C, et al. Development and biopharmaceutical evaluation of osmotic pump tablets for controlled delivery of diclofenac sodium. Acta Pharm. 2003;53(4):263-73.
Rani, M., Surana, R., Sankar, C., & Mishra, B. (2003). Development and biopharmaceutical evaluation of osmotic pump tablets for controlled delivery of diclofenac sodium. Acta Pharmaceutica (Zagreb, Croatia), 53(4), 263-73.
Rani M, et al. Development and Biopharmaceutical Evaluation of Osmotic Pump Tablets for Controlled Delivery of Diclofenac Sodium. Acta Pharm. 2003;53(4):263-73. PubMed PMID: 14769233.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and biopharmaceutical evaluation of osmotic pump tablets for controlled delivery of diclofenac sodium. AU - Rani,Meena, AU - Surana,Rahul, AU - Sankar,Chelladurai, AU - Mishra,Brahmeshwar, PY - 2004/2/11/pubmed PY - 2004/3/9/medline PY - 2004/2/11/entrez SP - 263 EP - 73 JF - Acta pharmaceutica (Zagreb, Croatia) JO - Acta Pharm VL - 53 IS - 4 N2 - Based on the principles of an elementary osmotic pump (OP), OP tablets were designed and evaluated with the aim to deliver diclofenac sodium (DS) in a controlled manner. In vitro evaluation was done in various release media and kinetics was evaluated using the regression coefficient analysis. Effects of orifice size, coating membrane type, coating thickness, static and stirred conditions and pH variation were studied. In vivo evaluation was performed on six healthy human volunteers and various pharmacokinetic parameters (c(max), t(max), AUC(0-24), MRT) and relative bioavailability were calculated. The results were compared with the performance of two commercial tablets of DS. The drug release from OP tablets was dependent on the type and thickness of the coating membrane, but was independent of the orifice size and static and stirred conditions of the release medium. The OP tablets provided a prolonged and controlled DS release compared to commercial sustained-release and conventional tablets of DS. SN - 1330-0075 UR - https://www.unboundmedicine.com/medline/citation/14769233/Development_and_biopharmaceutical_evaluation_of_osmotic_pump_tablets_for_controlled_delivery_of_diclofenac_sodium_ DB - PRIME DP - Unbound Medicine ER -