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[Effects of diisopropylfluorophosphate, paraoxon and dichlophos on [3H] quinuclidinyl benzylate binding to the rat striatum synaptic membranes].
Biull Eksp Biol Med. 1992 Sep; 114(9):290-1.BE

Abstract

The binding of [3H] quinuclidinyl benzilate (QNB) to rat striatum membranes after diisopropylfluorophosphate (DFP) induced seizures was characterized. There was a 36% decrease in Kd and a 33% decrease in the number of muscarinic receptors. Paraoxon caused inhibition fo [3H] QNB binding to the striatal membranes of intact rats. It is possible that a direct action of DFP on the muscarinic receptor is not the cause of anti-cholinesterase-induced changes in [3H] QNB binding.

Authors

Golovko AI
No affiliation info available
Sofronov GA
No affiliation info available
Nikolaeva TV
No affiliation info available
Kliuntina TV
No affiliation info available

MeSH

AnimalsCorpus StriatumDichlorvosIn Vitro TechniquesIsoflurophateMaleParaoxonQuinuclidinyl BenzilateRatsReceptors, MuscarinicSeizuresSynaptosomes

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

rus

PubMed ID

1477363

Citation

Golovko, A I., et al. "[Effects of Diisopropylfluorophosphate, Paraoxon and Dichlophos On [3H] Quinuclidinyl Benzylate Binding to the Rat Striatum Synaptic Membranes]." Biulleten' Eksperimental'noi Biologii I Meditsiny, vol. 114, no. 9, 1992, pp. 290-1.
Golovko AI, Sofronov GA, Nikolaeva TV, et al. [Effects of diisopropylfluorophosphate, paraoxon and dichlophos on [3H] quinuclidinyl benzylate binding to the rat striatum synaptic membranes]. Biull Eksp Biol Med. 1992;114(9):290-1.
Golovko, A. I., Sofronov, G. A., Nikolaeva, T. V., & Kliuntina, T. V. (1992). [Effects of diisopropylfluorophosphate, paraoxon and dichlophos on [3H] quinuclidinyl benzylate binding to the rat striatum synaptic membranes]. Biulleten' Eksperimental'noi Biologii I Meditsiny, 114(9), 290-1.
Golovko AI, et al. [Effects of Diisopropylfluorophosphate, Paraoxon and Dichlophos On [3H] Quinuclidinyl Benzylate Binding to the Rat Striatum Synaptic Membranes]. Biull Eksp Biol Med. 1992;114(9):290-1. PubMed PMID: 1477363.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of diisopropylfluorophosphate, paraoxon and dichlophos on [3H] quinuclidinyl benzylate binding to the rat striatum synaptic membranes]. AU - Golovko,A I, AU - Sofronov,G A, AU - Nikolaeva,T V, AU - Kliuntina,T V, PY - 1992/9/1/pubmed PY - 1992/9/1/medline PY - 1992/9/1/entrez SP - 290 EP - 1 JF - Biulleten' eksperimental'noi biologii i meditsiny JO - Biull Eksp Biol Med VL - 114 IS - 9 N2 - The binding of [3H] quinuclidinyl benzilate (QNB) to rat striatum membranes after diisopropylfluorophosphate (DFP) induced seizures was characterized. There was a 36% decrease in Kd and a 33% decrease in the number of muscarinic receptors. Paraoxon caused inhibition fo [3H] QNB binding to the striatal membranes of intact rats. It is possible that a direct action of DFP on the muscarinic receptor is not the cause of anti-cholinesterase-induced changes in [3H] QNB binding. SN - 0365-9615 UR - https://www.unboundmedicine.com/medline/citation/1477363/[Effects_of_diisopropylfluorophosphate_paraoxon_and_dichlophos_on_[3H]_quinuclidinyl_benzylate_binding_to_the_rat_striatum_synaptic_membranes]_ DB - PRIME DP - Unbound Medicine ER -