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The role of olfactory bulb norepinephrine in early olfactory learning.
Brain Res Dev Brain Res. 1992 Dec 18; 70(2):279-82.BR

Abstract

Wistar rat pups were implanted with bilateral olfactory bulb cannulas on postnatal day 5 (PN5). On PN6, pups were trained in an olfactory classical conditioning task with peppermint odor as the CS and tactile stimulation/stroking as the UCS. Pups were randomly assigned to either PAIRED, BACKWARD or ODOR-only conditions. Half the pups in each group received intrabulbar infusions of 100 microM propranolol and half received intrabulbar infusions of saline during the training session. Propranolol infusions blocked acquisition of the learned odor preference expressed by PAIRED saline-infused pups. Diffusion of the infusate was checked in additional pups by infusing [3H]NE and performing LSC analysis. Infusate concentration did not significantly differ between the anterior and posterior halves of the bulb, but were sharply lower in the olfactory peduncle and more posterior areas. The results suggest that olfactory bulb NE is critical for early olfactory learning.

Authors+Show Affiliations

Department of Psychology, University of Oklahoma, Norman 73019.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1477962

Citation

Sullivan, R M., et al. "The Role of Olfactory Bulb Norepinephrine in Early Olfactory Learning." Brain Research. Developmental Brain Research, vol. 70, no. 2, 1992, pp. 279-82.
Sullivan RM, Zyzak DR, Skierkowski P, et al. The role of olfactory bulb norepinephrine in early olfactory learning. Brain Res Dev Brain Res. 1992;70(2):279-82.
Sullivan, R. M., Zyzak, D. R., Skierkowski, P., & Wilson, D. A. (1992). The role of olfactory bulb norepinephrine in early olfactory learning. Brain Research. Developmental Brain Research, 70(2), 279-82.
Sullivan RM, et al. The Role of Olfactory Bulb Norepinephrine in Early Olfactory Learning. Brain Res Dev Brain Res. 1992 Dec 18;70(2):279-82. PubMed PMID: 1477962.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of olfactory bulb norepinephrine in early olfactory learning. AU - Sullivan,R M, AU - Zyzak,D R, AU - Skierkowski,P, AU - Wilson,D A, PY - 1992/12/18/pubmed PY - 1992/12/18/medline PY - 1992/12/18/entrez SP - 279 EP - 82 JF - Brain research. Developmental brain research JO - Brain Res Dev Brain Res VL - 70 IS - 2 N2 - Wistar rat pups were implanted with bilateral olfactory bulb cannulas on postnatal day 5 (PN5). On PN6, pups were trained in an olfactory classical conditioning task with peppermint odor as the CS and tactile stimulation/stroking as the UCS. Pups were randomly assigned to either PAIRED, BACKWARD or ODOR-only conditions. Half the pups in each group received intrabulbar infusions of 100 microM propranolol and half received intrabulbar infusions of saline during the training session. Propranolol infusions blocked acquisition of the learned odor preference expressed by PAIRED saline-infused pups. Diffusion of the infusate was checked in additional pups by infusing [3H]NE and performing LSC analysis. Infusate concentration did not significantly differ between the anterior and posterior halves of the bulb, but were sharply lower in the olfactory peduncle and more posterior areas. The results suggest that olfactory bulb NE is critical for early olfactory learning. SN - 0165-3806 UR - https://www.unboundmedicine.com/medline/citation/1477962/The_role_of_olfactory_bulb_norepinephrine_in_early_olfactory_learning_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0165-3806(92)90207-D DB - PRIME DP - Unbound Medicine ER -