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Inhaled frusemide and exercise induced asthma: evidence of a role for inhibitory prostanoids.
Thorax. 1992 Oct; 47(10):797-800.T

Abstract

BACKGROUND

Inhaled frusemide protects subjects with asthma against a wide range of bronchoconstrictor challenges, including allergen, exercise and inhaled sodium metabisulphite. An investigation was designed to determine whether this protection is related to the production of inhibitory prostaglandins, such as prostaglandin E2 (PGE2), by studying the effect of the cyclooxygenase inhibitor indomethacin on the protection afforded by inhaled frusemide against exercise induced asthma.

METHODS

In a double blind crossover study 10 subjects with mild asthma were pretreated with indomethacin (50 mg thrice daily) or placebo capsules for three days; they then inhaled frusemide (40 mg) or placebo 10 minutes before an exercise test previously shown to cause a 20-30% fall in forced expiratory volume in one second (FEV1).

RESULTS

After inhalation of placebo exercise caused a similar maximum fall in FEV1 whether pretreatment was with placebo (26%) or indomethacin (25.2%). After inhalation of frusemide the maximum fall in FEV1 was reduced to 14.3% after placebo pretreatment and to 21.8% after indomethacin pretreatment; the difference between placebo and indomethacin pretreatment was significant (mean difference 7.5%, 95% limits 0.6%, 14.4%). The inhibitory effect of frusemide on the response to exercise, assessed as change in FEV1 over 30 minutes, was significantly greater with placebo (62%) than indomethacin (13%) pretreatment.

CONCLUSION

These findings support a role for inhibitory prostanoids, such as PGE2, in the beneficial effects of frusemide as a protection against exercise induced asthma.

Links

Publisher Full Text
ncbi.nlm.nih.gov
thorax.bmj.com
PMC Free PDF

Authors+Show Affiliations

Pavord ID
Respiratory Medicine Unit, City Hospital, Nottingham.
Wisniewski A
No affiliation info available
Tattersfield AE
No affiliation info available

MeSH

Administration, InhalationAdolescentAdultAsthma, Exercise-InducedDouble-Blind MethodExercise TestFemaleForced Expiratory VolumeFurosemideHumansIndomethacinLungMaleMiddle Aged

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1481179

Citation

Pavord, I D., et al. "Inhaled Frusemide and Exercise Induced Asthma: Evidence of a Role for Inhibitory Prostanoids." Thorax, vol. 47, no. 10, 1992, pp. 797-800.
Pavord ID, Wisniewski A, Tattersfield AE. Inhaled frusemide and exercise induced asthma: evidence of a role for inhibitory prostanoids. Thorax. 1992;47(10):797-800.
Pavord, I. D., Wisniewski, A., & Tattersfield, A. E. (1992). Inhaled frusemide and exercise induced asthma: evidence of a role for inhibitory prostanoids. Thorax, 47(10), 797-800.
Pavord ID, Wisniewski A, Tattersfield AE. Inhaled Frusemide and Exercise Induced Asthma: Evidence of a Role for Inhibitory Prostanoids. Thorax. 1992;47(10):797-800. PubMed PMID: 1481179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhaled frusemide and exercise induced asthma: evidence of a role for inhibitory prostanoids. AU - Pavord,I D, AU - Wisniewski,A, AU - Tattersfield,A E, PY - 1992/10/1/pubmed PY - 1992/10/1/medline PY - 1992/10/1/entrez SP - 797 EP - 800 JF - Thorax JO - Thorax VL - 47 IS - 10 N2 - BACKGROUND: Inhaled frusemide protects subjects with asthma against a wide range of bronchoconstrictor challenges, including allergen, exercise and inhaled sodium metabisulphite. An investigation was designed to determine whether this protection is related to the production of inhibitory prostaglandins, such as prostaglandin E2 (PGE2), by studying the effect of the cyclooxygenase inhibitor indomethacin on the protection afforded by inhaled frusemide against exercise induced asthma. METHODS: In a double blind crossover study 10 subjects with mild asthma were pretreated with indomethacin (50 mg thrice daily) or placebo capsules for three days; they then inhaled frusemide (40 mg) or placebo 10 minutes before an exercise test previously shown to cause a 20-30% fall in forced expiratory volume in one second (FEV1). RESULTS: After inhalation of placebo exercise caused a similar maximum fall in FEV1 whether pretreatment was with placebo (26%) or indomethacin (25.2%). After inhalation of frusemide the maximum fall in FEV1 was reduced to 14.3% after placebo pretreatment and to 21.8% after indomethacin pretreatment; the difference between placebo and indomethacin pretreatment was significant (mean difference 7.5%, 95% limits 0.6%, 14.4%). The inhibitory effect of frusemide on the response to exercise, assessed as change in FEV1 over 30 minutes, was significantly greater with placebo (62%) than indomethacin (13%) pretreatment. CONCLUSION: These findings support a role for inhibitory prostanoids, such as PGE2, in the beneficial effects of frusemide as a protection against exercise induced asthma. SN - 0040-6376 UR - https://www.unboundmedicine.com/medline/citation/1481179/Inhaled_frusemide_and_exercise_induced_asthma:_evidence_of_a_role_for_inhibitory_prostanoids_ L2 - https://thorax.bmj.com/lookup/pmidlookup?view=long&pmid=1481179 DB - PRIME DP - Unbound Medicine ER -