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Osteoporosis in anorexia nervosa: the influence of peak bone density, bone loss, oral contraceptive use, and exercise.
J Bone Miner Res 1992; 7(12):1467-74JB

Abstract

Anorexia nervosa occurs early in life and predisposes to osteoporosis. Exercise may be protective. We asked: (1) Does failure to attain peak bone density contribute to the deficit in bone density? (2) Does oral contraceptive use protect against osteoporosis? (3) Is any protective effect of exercise confined to weight-bearing sites? Areal bone density (g/cm2) and body composition were measured by dual x-ray absorptiometry in 65 patients with anorexia nervosa and 52 controls. Comparing the 12 patients with primary amenorrhea and the 37 patients with secondary amenorrhea, bone density (mean +/- SEM) at the lumbar spine was 0.88 +/- 0.04 versus 1.06 +/- 0.03 (P = 0.001), respectively. Bone density at the femoral neck was 0.80 +/- 0.04 versus 0.92 +/- 0.03 (P < 0.05), respectively. These values differed before, but not after, adjusting for the respective duration of illness (73.0 +/- 10.3 versus 34.1 +/- 4.8 months, P < 0.001) and fat-free mass (31.6 +/- 1.3 versus 35.4 +/- 0.5 kg, P < 0.01). Bone density at the lumbar spine in the 16 patients with 31.8 +/- 8.3 months of contraceptive exposure was higher than in the 49 patients with no contraceptive exposure (1.14 +/- 0.05 versus 1.02 +/- 0.02 P < 0.02) but was lower than in controls (1.14 +/- 0.05 versus 1.27 +/- 1.02, P < 0.01). No protective effect of contraceptive exposure was detectable at the femoral neck.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Endocrinology, Austin Hospital, Melbourne, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1481732

Citation

Seeman, E, et al. "Osteoporosis in Anorexia Nervosa: the Influence of Peak Bone Density, Bone Loss, Oral Contraceptive Use, and Exercise." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 7, no. 12, 1992, pp. 1467-74.
Seeman E, Szmukler GI, Formica C, et al. Osteoporosis in anorexia nervosa: the influence of peak bone density, bone loss, oral contraceptive use, and exercise. J Bone Miner Res. 1992;7(12):1467-74.
Seeman, E., Szmukler, G. I., Formica, C., Tsalamandris, C., & Mestrovic, R. (1992). Osteoporosis in anorexia nervosa: the influence of peak bone density, bone loss, oral contraceptive use, and exercise. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 7(12), pp. 1467-74.
Seeman E, et al. Osteoporosis in Anorexia Nervosa: the Influence of Peak Bone Density, Bone Loss, Oral Contraceptive Use, and Exercise. J Bone Miner Res. 1992;7(12):1467-74. PubMed PMID: 1481732.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Osteoporosis in anorexia nervosa: the influence of peak bone density, bone loss, oral contraceptive use, and exercise. AU - Seeman,E, AU - Szmukler,G I, AU - Formica,C, AU - Tsalamandris,C, AU - Mestrovic,R, PY - 1992/12/1/pubmed PY - 1992/12/1/medline PY - 1992/12/1/entrez KW - Amenorrhea KW - Australia KW - Biology KW - Body Weight KW - Case Control Studies KW - Comparative Studies KW - Contraception KW - Contraceptive Methods--side effects KW - Deficiency Diseases KW - Developed Countries KW - Diseases KW - Endocrine System KW - Estrogens KW - Family Planning KW - Hormones KW - Menstruation Disorders KW - Nutrition Disorders KW - Oceania KW - Oral Contraceptives--side effects KW - Physiology KW - Research Methodology KW - Studies KW - Treatment SP - 1467 EP - 74 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 7 IS - 12 N2 - Anorexia nervosa occurs early in life and predisposes to osteoporosis. Exercise may be protective. We asked: (1) Does failure to attain peak bone density contribute to the deficit in bone density? (2) Does oral contraceptive use protect against osteoporosis? (3) Is any protective effect of exercise confined to weight-bearing sites? Areal bone density (g/cm2) and body composition were measured by dual x-ray absorptiometry in 65 patients with anorexia nervosa and 52 controls. Comparing the 12 patients with primary amenorrhea and the 37 patients with secondary amenorrhea, bone density (mean +/- SEM) at the lumbar spine was 0.88 +/- 0.04 versus 1.06 +/- 0.03 (P = 0.001), respectively. Bone density at the femoral neck was 0.80 +/- 0.04 versus 0.92 +/- 0.03 (P < 0.05), respectively. These values differed before, but not after, adjusting for the respective duration of illness (73.0 +/- 10.3 versus 34.1 +/- 4.8 months, P < 0.001) and fat-free mass (31.6 +/- 1.3 versus 35.4 +/- 0.5 kg, P < 0.01). Bone density at the lumbar spine in the 16 patients with 31.8 +/- 8.3 months of contraceptive exposure was higher than in the 49 patients with no contraceptive exposure (1.14 +/- 0.05 versus 1.02 +/- 0.02 P < 0.02) but was lower than in controls (1.14 +/- 0.05 versus 1.27 +/- 1.02, P < 0.01). No protective effect of contraceptive exposure was detectable at the femoral neck.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/1481732/Osteoporosis_in_anorexia_nervosa:_the_influence_of_peak_bone_density_bone_loss_oral_contraceptive_use_and_exercise_ L2 - https://doi.org/10.1002/jbmr.5650071215 DB - PRIME DP - Unbound Medicine ER -