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Stimulatory (H1) and inhibitory (H2) histamine receptors in gallbladder muscle.
Gastroenterology. 1977 May; 72(5 Pt 1):932-6.G

Abstract

The nature of histamine receptors in gallbladder muscle and examined using specific histamine-receptor agonists and antagonists. The H2-receptor antagonist, metiamide, augmented the contractile response to histamine indicating that gallbladder muscle possessed stimulatory H1 receptors and inhibitory H2 receptors. The independent inhibitory character of H2 receptors was confirmed by (1) induction of relaxation with histamine after H1-receptor blockade and the suppression of this relaxation with metiamide, and (2) induction of relaxation with a specific H2-receptor agonist, 4-methyl histamine and the suppression of this relaxation with metiamide. Further, blockade of H2 but not of H1 receptors augmented the response to the octapeptide of cholecystokinin. The nature of this effect was such that the apparent affinity of the octapeptide for its own receptor was increased. The finding raised the possibility that in their native unoccupied state, H2 receptors may modify the response to hormonal agents.

Authors

Waldman DB
No affiliation info available
Zfass AM
No affiliation info available
Makhlouf GM
No affiliation info available

MeSH

AnimalsCholecystokininDose-Response Relationship, DrugDrug AntagonismDrug SynergismFemaleGallbladderGuinea PigsHistamineHistamine H1 AntagonistsHistamine H2 AntagonistsMetiamideMuscle, SmoothPeptidesPotassium ChlorideReceptors, HistamineReceptors, Histamine H1Receptors, Histamine H2

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14867

Citation

Waldman, D B., et al. "Stimulatory (H1) and Inhibitory (H2) Histamine Receptors in Gallbladder Muscle." Gastroenterology, vol. 72, no. 5 Pt 1, 1977, pp. 932-6.
Waldman DB, Zfass AM, Makhlouf GM. Stimulatory (H1) and inhibitory (H2) histamine receptors in gallbladder muscle. Gastroenterology. 1977;72(5 Pt 1):932-6.
Waldman, D. B., Zfass, A. M., & Makhlouf, G. M. (1977). Stimulatory (H1) and inhibitory (H2) histamine receptors in gallbladder muscle. Gastroenterology, 72(5 Pt 1), 932-6.
Waldman DB, Zfass AM, Makhlouf GM. Stimulatory (H1) and Inhibitory (H2) Histamine Receptors in Gallbladder Muscle. Gastroenterology. 1977;72(5 Pt 1):932-6. PubMed PMID: 14867.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stimulatory (H1) and inhibitory (H2) histamine receptors in gallbladder muscle. AU - Waldman,D B, AU - Zfass,A M, AU - Makhlouf,G M, PY - 1977/5/1/pubmed PY - 1977/5/1/medline PY - 1977/5/1/entrez SP - 932 EP - 6 JF - Gastroenterology JO - Gastroenterology VL - 72 IS - 5 Pt 1 N2 - The nature of histamine receptors in gallbladder muscle and examined using specific histamine-receptor agonists and antagonists. The H2-receptor antagonist, metiamide, augmented the contractile response to histamine indicating that gallbladder muscle possessed stimulatory H1 receptors and inhibitory H2 receptors. The independent inhibitory character of H2 receptors was confirmed by (1) induction of relaxation with histamine after H1-receptor blockade and the suppression of this relaxation with metiamide, and (2) induction of relaxation with a specific H2-receptor agonist, 4-methyl histamine and the suppression of this relaxation with metiamide. Further, blockade of H2 but not of H1 receptors augmented the response to the octapeptide of cholecystokinin. The nature of this effect was such that the apparent affinity of the octapeptide for its own receptor was increased. The finding raised the possibility that in their native unoccupied state, H2 receptors may modify the response to hormonal agents. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/14867/Stimulatory__H1__and_inhibitory__H2__histamine_receptors_in_gallbladder_muscle_ DB - PRIME DP - Unbound Medicine ER -