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Protective effect of loop diuretics, piretanide and frusemide, against sodium metabisulphite-induced bronchoconstriction in asthma.
Eur Respir J. 1992 Nov; 5(10):1184-8.ER

Abstract

We determined whether the loop diuretic, piretanide, had a similar inhibitory action against sodium metabisulphite (MBS)-induced bronchoconstriction in asthmatic subjects as frusemide and, if so, its duration of action. In the first study, we compared the effect of inhaled placebo, piretanide (24 mg), or frusemide (40 mg), on the provocative concentration of MBS needed to cause a 20% fall in baseline forced expiratory volume in one second (FEV1) (PC20MBS) in 12 mild asthmatic subjects before, immediately after, and at 1.5, 3, 6, and 24 h, after inhalation. Both piretanide and frusemide induced a significant diuresis lasting at least 24 h. Frusemide caused a mean 3.8 fold (95% confidence interval: 2.3-6.3 fold), piretanide a 2.5 fold (1.8-3.4 fold) and placebo a 1.7 fold (1.5-1.9 fold) increase in PC20MBS. The effects of frusemide and piretanide were significantly greater than that of placebo. At later time points, tachyphylaxis to the bronchoconstrictor effects of MBS was observed during the placebo limb. In the second study, we measured PC20MBS at 90 min after inhalation of either placebo, piretanide (24 mg), or frusemide (40 mg). No significant difference in PC20MBS was observed. We conclude that piretanide in addition to frusemide significantly inhibits MBS-induced bronchoconstriction and that this action is short-lived over less than 90 min. Frusemide was more potent in inhibiting MBS-induced bronchoconstriction despite causing a smaller diuretic effect than piretanide. The basic mechanism of action of the loop diuretics in the airways remains unclear.

Authors+Show Affiliations

Health Manpower Development Program of Singapore.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1486963

Citation

Yeo, C T., et al. "Protective Effect of Loop Diuretics, Piretanide and Frusemide, Against Sodium Metabisulphite-induced Bronchoconstriction in Asthma." The European Respiratory Journal, vol. 5, no. 10, 1992, pp. 1184-8.
Yeo CT, O'Connor BJ, Chen-Worsdell M, et al. Protective effect of loop diuretics, piretanide and frusemide, against sodium metabisulphite-induced bronchoconstriction in asthma. Eur Respir J. 1992;5(10):1184-8.
Yeo, C. T., O'Connor, B. J., Chen-Worsdell, M., Barnes, P. J., & Chung, K. F. (1992). Protective effect of loop diuretics, piretanide and frusemide, against sodium metabisulphite-induced bronchoconstriction in asthma. The European Respiratory Journal, 5(10), 1184-8.
Yeo CT, et al. Protective Effect of Loop Diuretics, Piretanide and Frusemide, Against Sodium Metabisulphite-induced Bronchoconstriction in Asthma. Eur Respir J. 1992;5(10):1184-8. PubMed PMID: 1486963.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effect of loop diuretics, piretanide and frusemide, against sodium metabisulphite-induced bronchoconstriction in asthma. AU - Yeo,C T, AU - O'Connor,B J, AU - Chen-Worsdell,M, AU - Barnes,P J, AU - Chung,K F, PY - 1992/11/1/pubmed PY - 1992/11/1/medline PY - 1992/11/1/entrez SP - 1184 EP - 8 JF - The European respiratory journal JO - Eur Respir J VL - 5 IS - 10 N2 - We determined whether the loop diuretic, piretanide, had a similar inhibitory action against sodium metabisulphite (MBS)-induced bronchoconstriction in asthmatic subjects as frusemide and, if so, its duration of action. In the first study, we compared the effect of inhaled placebo, piretanide (24 mg), or frusemide (40 mg), on the provocative concentration of MBS needed to cause a 20% fall in baseline forced expiratory volume in one second (FEV1) (PC20MBS) in 12 mild asthmatic subjects before, immediately after, and at 1.5, 3, 6, and 24 h, after inhalation. Both piretanide and frusemide induced a significant diuresis lasting at least 24 h. Frusemide caused a mean 3.8 fold (95% confidence interval: 2.3-6.3 fold), piretanide a 2.5 fold (1.8-3.4 fold) and placebo a 1.7 fold (1.5-1.9 fold) increase in PC20MBS. The effects of frusemide and piretanide were significantly greater than that of placebo. At later time points, tachyphylaxis to the bronchoconstrictor effects of MBS was observed during the placebo limb. In the second study, we measured PC20MBS at 90 min after inhalation of either placebo, piretanide (24 mg), or frusemide (40 mg). No significant difference in PC20MBS was observed. We conclude that piretanide in addition to frusemide significantly inhibits MBS-induced bronchoconstriction and that this action is short-lived over less than 90 min. Frusemide was more potent in inhibiting MBS-induced bronchoconstriction despite causing a smaller diuretic effect than piretanide. The basic mechanism of action of the loop diuretics in the airways remains unclear. SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/1486963/Protective_effect_of_loop_diuretics_piretanide_and_frusemide_against_sodium_metabisulphite_induced_bronchoconstriction_in_asthma_ L2 - https://www.diseaseinfosearch.org/result/633 DB - PRIME DP - Unbound Medicine ER -