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The effect of amiloride on the airway response to metabisulphite in asthma: a negative report.
Eur Respir J. 1992 Nov; 5(10):1189-92.ER

Abstract

Frusemide, a loop diuretic, has been shown to potently inhibit several indirect bronchoconstrictor challenges in asthma. The mechanism by which nebulized frusemide protects against indirect bronchoconstrictor stimuli in asthma is not known. One mechanism could be related to inhibition of sodium transport. If this is the case, then amiloride, another inhibitor of sodium transport, should also protect against indirect bronchoconstrictor challenges. Ten subjects with mild asthma were administered either 10(-2) M amiloride or placebo, by nebulizer, in a double-blind crossover fashion. After each inhalation, forced expiratory volume in one second (FEV1) was recorded at 10 min intervals for 30 min, after which a metabisulphite challenge was performed. No significant difference in the response to metabisulphite was seen between placebo and amiloride treatment. The mean difference in provocative dose of metabisulphite producing a 20% fall in FEV1 (PD20) between placebo and amiloride was 1.015 doubling doses, 95% confidence interval (95% CI) -0.201 to 2.231, (p = 0.09). This result does not support the hypothesis that frusemide is acting to protect against bronchoconstrictor challenges in asthma by an effect on sodium transport.

Authors+Show Affiliations

Respiratory Medicine Unit, City Hospital, Nottingham, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1486964

Citation

Baldwin, D R., et al. "The Effect of Amiloride On the Airway Response to Metabisulphite in Asthma: a Negative Report." The European Respiratory Journal, vol. 5, no. 10, 1992, pp. 1189-92.
Baldwin DR, Grange KL, Pavord I, et al. The effect of amiloride on the airway response to metabisulphite in asthma: a negative report. Eur Respir J. 1992;5(10):1189-92.
Baldwin, D. R., Grange, K. L., Pavord, I., & Knox, A. J. (1992). The effect of amiloride on the airway response to metabisulphite in asthma: a negative report. The European Respiratory Journal, 5(10), 1189-92.
Baldwin DR, et al. The Effect of Amiloride On the Airway Response to Metabisulphite in Asthma: a Negative Report. Eur Respir J. 1992;5(10):1189-92. PubMed PMID: 1486964.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of amiloride on the airway response to metabisulphite in asthma: a negative report. AU - Baldwin,D R, AU - Grange,K L, AU - Pavord,I, AU - Knox,A J, PY - 1992/11/1/pubmed PY - 1992/11/1/medline PY - 1992/11/1/entrez SP - 1189 EP - 92 JF - The European respiratory journal JO - Eur Respir J VL - 5 IS - 10 N2 - Frusemide, a loop diuretic, has been shown to potently inhibit several indirect bronchoconstrictor challenges in asthma. The mechanism by which nebulized frusemide protects against indirect bronchoconstrictor stimuli in asthma is not known. One mechanism could be related to inhibition of sodium transport. If this is the case, then amiloride, another inhibitor of sodium transport, should also protect against indirect bronchoconstrictor challenges. Ten subjects with mild asthma were administered either 10(-2) M amiloride or placebo, by nebulizer, in a double-blind crossover fashion. After each inhalation, forced expiratory volume in one second (FEV1) was recorded at 10 min intervals for 30 min, after which a metabisulphite challenge was performed. No significant difference in the response to metabisulphite was seen between placebo and amiloride treatment. The mean difference in provocative dose of metabisulphite producing a 20% fall in FEV1 (PD20) between placebo and amiloride was 1.015 doubling doses, 95% confidence interval (95% CI) -0.201 to 2.231, (p = 0.09). This result does not support the hypothesis that frusemide is acting to protect against bronchoconstrictor challenges in asthma by an effect on sodium transport. SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/1486964/The_effect_of_amiloride_on_the_airway_response_to_metabisulphite_in_asthma:_a_negative_report_ L2 - https://www.diseaseinfosearch.org/result/633 DB - PRIME DP - Unbound Medicine ER -