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Double-blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24-h oesophageal and intragastric pH in Chinese subjects with gastro-oesophageal reflux disease.

Abstract

BACKGROUND

Previous studies have suggested that the acid secretory capacity of the Chinese population is lower than that of the Western population.

AIM

To compare the effect of lansoprazole 30 mg and 15 mg once daily on the 24-h oesophageal and intragastric pH profiles in Chinese patients with gastro-oesophageal reflux disease.

METHODS

Forty-four patients (male to female ratio, 27 : 17; mean age, 53 years; 55% with oesophagitis) with gastro-oesophageal reflux disease were randomized to receive lansoprazole 30 mg or 15 mg once daily for 4 weeks. Measurement of the 24-h oesophageal and intragastric pH, gastro-oesophageal reflux disease symptoms and quality of life was performed at baseline and during the last week of each dosing period.

RESULTS

Lansoprazole 30 mg maintained an intragastric pH > 4 for 10.5 h vs. 9.6 h for lansoprazole 15 mg (P = 0.44). The percentage total time at oesophageal pH < 4 was similar for lansoprazole 30 mg and 15 mg (2.0% vs. 2.3%, P = 0.30). The proportion of patients with complete cure of heartburn and acid regurgitation and the quality of life assessment were similar for lansoprazole 30 mg and 15 mg. Both dosages of lansoprazole were well tolerated and the compliance was 100% in both groups.

CONCLUSION

Lansoprazole dosages of 30 mg and 15 mg once daily provide a satisfactory decrease for oesophageal acid exposure and are equally effective for the treatment of gastro-oesophageal reflux disease in the Chinese population.

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  • Authors+Show Affiliations

    ,

    Department of Medicine, University of Hong Kong, Hong Kong SAR, China.

    , , , , , , , , , ,

    Source

    Alimentary pharmacology & therapeutics 19:4 2004 Feb 15 pg 455-62

    MeSH

    2-Pyridinylmethylsulfinylbenzimidazoles
    Anti-Ulcer Agents
    China
    Cross-Over Studies
    Double-Blind Method
    Female
    Gastric Acidity Determination
    Gastroesophageal Reflux
    Humans
    Hydrogen-Ion Concentration
    Lansoprazole
    Male
    Middle Aged
    Omeprazole
    Treatment Outcome

    Pub Type(s)

    Clinical Trial
    Journal Article
    Randomized Controlled Trial
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14871286

    Citation

    Wong, W M., et al. "Double-blind, Randomized Controlled Study to Assess the Effects of Lansoprazole 30 Mg and Lansoprazole 15 Mg On 24-h Oesophageal and Intragastric pH in Chinese Subjects With Gastro-oesophageal Reflux Disease." Alimentary Pharmacology & Therapeutics, vol. 19, no. 4, 2004, pp. 455-62.
    Wong WM, Lai KC, Hui WM, et al. Double-blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24-h oesophageal and intragastric pH in Chinese subjects with gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2004;19(4):455-62.
    Wong, W. M., Lai, K. C., Hui, W. M., Lam, K. F., Huang, J. Q., Hu, W. H., ... Wong, B. C. (2004). Double-blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24-h oesophageal and intragastric pH in Chinese subjects with gastro-oesophageal reflux disease. Alimentary Pharmacology & Therapeutics, 19(4), pp. 455-62.
    Wong WM, et al. Double-blind, Randomized Controlled Study to Assess the Effects of Lansoprazole 30 Mg and Lansoprazole 15 Mg On 24-h Oesophageal and Intragastric pH in Chinese Subjects With Gastro-oesophageal Reflux Disease. Aliment Pharmacol Ther. 2004 Feb 15;19(4):455-62. PubMed PMID: 14871286.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Double-blind, randomized controlled study to assess the effects of lansoprazole 30 mg and lansoprazole 15 mg on 24-h oesophageal and intragastric pH in Chinese subjects with gastro-oesophageal reflux disease. AU - Wong,W M, AU - Lai,K C, AU - Hui,W M, AU - Lam,K F, AU - Huang,J Q, AU - Hu,W H C, AU - Wong,N Y H, AU - Lam,C L K, AU - Xia,H H X, AU - Chan,A O O, AU - Lam,S K, AU - Wong,B C Y, PY - 2004/2/12/pubmed PY - 2004/4/17/medline PY - 2004/2/12/entrez SP - 455 EP - 62 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 19 IS - 4 N2 - BACKGROUND: Previous studies have suggested that the acid secretory capacity of the Chinese population is lower than that of the Western population. AIM: To compare the effect of lansoprazole 30 mg and 15 mg once daily on the 24-h oesophageal and intragastric pH profiles in Chinese patients with gastro-oesophageal reflux disease. METHODS: Forty-four patients (male to female ratio, 27 : 17; mean age, 53 years; 55% with oesophagitis) with gastro-oesophageal reflux disease were randomized to receive lansoprazole 30 mg or 15 mg once daily for 4 weeks. Measurement of the 24-h oesophageal and intragastric pH, gastro-oesophageal reflux disease symptoms and quality of life was performed at baseline and during the last week of each dosing period. RESULTS: Lansoprazole 30 mg maintained an intragastric pH > 4 for 10.5 h vs. 9.6 h for lansoprazole 15 mg (P = 0.44). The percentage total time at oesophageal pH < 4 was similar for lansoprazole 30 mg and 15 mg (2.0% vs. 2.3%, P = 0.30). The proportion of patients with complete cure of heartburn and acid regurgitation and the quality of life assessment were similar for lansoprazole 30 mg and 15 mg. Both dosages of lansoprazole were well tolerated and the compliance was 100% in both groups. CONCLUSION: Lansoprazole dosages of 30 mg and 15 mg once daily provide a satisfactory decrease for oesophageal acid exposure and are equally effective for the treatment of gastro-oesophageal reflux disease in the Chinese population. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/14871286/Double_blind_randomized_controlled_study_to_assess_the_effects_of_lansoprazole_30_mg_and_lansoprazole_15_mg_on_24_h_oesophageal_and_intragastric_pH_in_Chinese_subjects_with_gastro_oesophageal_reflux_disease_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=14871286.ui DB - PRIME DP - Unbound Medicine ER -