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Sleep enhances nocturnal plasma ghrelin levels in healthy subjects.
Am J Physiol Endocrinol Metab. 2004 Jun; 286(6):E963-7.AJ

Abstract

Ghrelin, an endogenous ligand of the growth hormone secretagogue receptor, has been shown to promote slow-wave sleep (SWS, non-REM sleep stages 3 and 4). Plasma levels of ghrelin are dependent on food intake and increase in sleeping subjects during the early part of the night. It is unknown whether sleep itself affects ghrelin levels or whether circadian networks are involved. Therefore, we studied the effect of sleep deprivation on nocturnal ghrelin secretion. In healthy male volunteers, plasma levels of ghrelin, cortisol, and human growth hormone (hGH) were measured during two experimental sessions of 24 h each: once when the subjects were allowed to sleep between 2300 and 0700 and once when they were kept awake throughout the night. During sleep, ghrelin levels increased during the early part of the night and decreased in the morning. This nocturnal increase was blunted during sleep deprivation, and ghrelin levels increased only slightly until the early morning. Ghrelin secretion during the first hours of sleep correlated positively with peak hGH concentrations. We conclude that the nocturnal increase in ghrelin levels is more likely to be caused by sleep-associated processes than by circadian influences. During the first hours of sleep, ghrelin might promote sleep-associated hGH secretion and contribute to the promotion of SWS.

Authors+Show Affiliations

Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14871884

Citation

Dzaja, Andrea, et al. "Sleep Enhances Nocturnal Plasma Ghrelin Levels in Healthy Subjects." American Journal of Physiology. Endocrinology and Metabolism, vol. 286, no. 6, 2004, pp. E963-7.
Dzaja A, Dalal MA, Himmerich H, et al. Sleep enhances nocturnal plasma ghrelin levels in healthy subjects. Am J Physiol Endocrinol Metab. 2004;286(6):E963-7.
Dzaja, A., Dalal, M. A., Himmerich, H., Uhr, M., Pollmächer, T., & Schuld, A. (2004). Sleep enhances nocturnal plasma ghrelin levels in healthy subjects. American Journal of Physiology. Endocrinology and Metabolism, 286(6), E963-7.
Dzaja A, et al. Sleep Enhances Nocturnal Plasma Ghrelin Levels in Healthy Subjects. Am J Physiol Endocrinol Metab. 2004;286(6):E963-7. PubMed PMID: 14871884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sleep enhances nocturnal plasma ghrelin levels in healthy subjects. AU - Dzaja,Andrea, AU - Dalal,Mira A, AU - Himmerich,Hubertus, AU - Uhr,Manfred, AU - Pollmächer,Thomas, AU - Schuld,Andreas, Y1 - 2004/02/10/ PY - 2004/2/12/pubmed PY - 2004/6/26/medline PY - 2004/2/12/entrez SP - E963 EP - 7 JF - American journal of physiology. Endocrinology and metabolism JO - Am J Physiol Endocrinol Metab VL - 286 IS - 6 N2 - Ghrelin, an endogenous ligand of the growth hormone secretagogue receptor, has been shown to promote slow-wave sleep (SWS, non-REM sleep stages 3 and 4). Plasma levels of ghrelin are dependent on food intake and increase in sleeping subjects during the early part of the night. It is unknown whether sleep itself affects ghrelin levels or whether circadian networks are involved. Therefore, we studied the effect of sleep deprivation on nocturnal ghrelin secretion. In healthy male volunteers, plasma levels of ghrelin, cortisol, and human growth hormone (hGH) were measured during two experimental sessions of 24 h each: once when the subjects were allowed to sleep between 2300 and 0700 and once when they were kept awake throughout the night. During sleep, ghrelin levels increased during the early part of the night and decreased in the morning. This nocturnal increase was blunted during sleep deprivation, and ghrelin levels increased only slightly until the early morning. Ghrelin secretion during the first hours of sleep correlated positively with peak hGH concentrations. We conclude that the nocturnal increase in ghrelin levels is more likely to be caused by sleep-associated processes than by circadian influences. During the first hours of sleep, ghrelin might promote sleep-associated hGH secretion and contribute to the promotion of SWS. SN - 0193-1849 UR - https://www.unboundmedicine.com/medline/citation/14871884/Sleep_enhances_nocturnal_plasma_ghrelin_levels_in_healthy_subjects_ L2 - https://journals.physiology.org/doi/10.1152/ajpendo.00527.2003?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -