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Ten year follow-up of healthy children who received one or two injections of varicella vaccine.
Pediatr Infect Dis J. 2004 Feb; 23(2):132-7.PI

Abstract

BACKGROUND

The rate of varicella and persistence of varicella antibody after a one dose vs. a two dose regimen of varicella virus vaccine live Oka/Merck (VARIVAX; Merck & Co., Inc., West Point, PA) in approximately 2000 children were compared during a 9- to 10-year follow-up period.

METHODS

Children 12 months to 12 years of age with a negative history of varicella were randomized in late 1991 to early 1993 to receive either one or two injections of varicella vaccine given 3 months apart. Subjects were actively followed for varicella, any varicella-like illness or zoster and any exposures to varicella or zoster on a yearly basis for 10 years after vaccination. Persistence of varicella antibody was measured yearly for 9 years.

RESULTS

Most cases of varicella reported in recipients of one or two injections of vaccine were mild. The risk of developing varicella >42 days postvaccination during the 10-year observation period was 3.3-fold lower (P < 0.001) in children who received two injections than in those who received one injection (2.2% vs. 7.3%, respectively). The estimated vaccine efficacy for the 10-year observation period was 94.4% for one injection and 98.3% for two injections (P < 0.001). Measurable serum antibody persisted for 9 years in all subjects.

CONCLUSIONS

Administration of either one or two injections of varicella vaccine to healthy children results in long term protection against most varicella disease. The two dose regimen was significantly more effective than a single injection.

Authors+Show Affiliations

Kuter B
Merck Research Laboratories, PO Box 4, West Point, PA 19486, USA. barbara_kuter@merck.com
Matthews H
No affiliation info available
Shinefield H
No affiliation info available
Black S
No affiliation info available
Dennehy P
No affiliation info available
Watson B
No affiliation info available
Reisinger K
No affiliation info available
Kim LL
No affiliation info available
Lupinacci L
No affiliation info available
Hartzel J
No affiliation info available
Chan I
No affiliation info available
Study Group for Varivax
No affiliation info available

MeSH

Age DistributionAntibodies, ViralChickenpoxChickenpox VaccineChildChild, PreschoolEnzyme-Linked Immunosorbent AssayFemaleFollow-Up StudiesHerpes ZosterHerpesvirus 3, HumanHumansImmunityImmunization ScheduleIncidenceInfantMaleProbabilityRisk AssessmentSex DistributionTime FactorsVaccinationVaccines, Attenuated

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14872179

Citation

Kuter, Barbara, et al. "Ten Year Follow-up of Healthy Children Who Received One or Two Injections of Varicella Vaccine." The Pediatric Infectious Disease Journal, vol. 23, no. 2, 2004, pp. 132-7.
Kuter B, Matthews H, Shinefield H, et al. Ten year follow-up of healthy children who received one or two injections of varicella vaccine. Pediatr Infect Dis J. 2004;23(2):132-7.
Kuter, B., Matthews, H., Shinefield, H., Black, S., Dennehy, P., Watson, B., Reisinger, K., Kim, L. L., Lupinacci, L., Hartzel, J., & Chan, I. (2004). Ten year follow-up of healthy children who received one or two injections of varicella vaccine. The Pediatric Infectious Disease Journal, 23(2), 132-7.
Kuter B, et al. Ten Year Follow-up of Healthy Children Who Received One or Two Injections of Varicella Vaccine. Pediatr Infect Dis J. 2004;23(2):132-7. PubMed PMID: 14872179.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ten year follow-up of healthy children who received one or two injections of varicella vaccine. AU - Kuter,Barbara, AU - Matthews,Holly, AU - Shinefield,Henry, AU - Black,Steve, AU - Dennehy,Penelope, AU - Watson,Barbara, AU - Reisinger,Keith, AU - Kim,Lee Lian, AU - Lupinacci,Lisa, AU - Hartzel,Jonathan, AU - Chan,Ivan, AU - ,, PY - 2004/2/12/pubmed PY - 2004/3/12/medline PY - 2004/2/12/entrez SP - 132 EP - 7 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 23 IS - 2 N2 - BACKGROUND: The rate of varicella and persistence of varicella antibody after a one dose vs. a two dose regimen of varicella virus vaccine live Oka/Merck (VARIVAX; Merck & Co., Inc., West Point, PA) in approximately 2000 children were compared during a 9- to 10-year follow-up period. METHODS: Children 12 months to 12 years of age with a negative history of varicella were randomized in late 1991 to early 1993 to receive either one or two injections of varicella vaccine given 3 months apart. Subjects were actively followed for varicella, any varicella-like illness or zoster and any exposures to varicella or zoster on a yearly basis for 10 years after vaccination. Persistence of varicella antibody was measured yearly for 9 years. RESULTS: Most cases of varicella reported in recipients of one or two injections of vaccine were mild. The risk of developing varicella >42 days postvaccination during the 10-year observation period was 3.3-fold lower (P < 0.001) in children who received two injections than in those who received one injection (2.2% vs. 7.3%, respectively). The estimated vaccine efficacy for the 10-year observation period was 94.4% for one injection and 98.3% for two injections (P < 0.001). Measurable serum antibody persisted for 9 years in all subjects. CONCLUSIONS: Administration of either one or two injections of varicella vaccine to healthy children results in long term protection against most varicella disease. The two dose regimen was significantly more effective than a single injection. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/14872179/Ten_year_follow_up_of_healthy_children_who_received_one_or_two_injections_of_varicella_vaccine_ DB - PRIME DP - Unbound Medicine ER -