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[IgA-class antigliadin antibodies in the screening and follow-up of celiac disease patients].
Pediatr Med Chir 1992 Sep-Oct; 14(5):517-9PM

Abstract

IgA antigliadin antibodies (IgA-AGA) have been determined with an enzyme immunoassay in 2.141 pediatric patients. High levels of IgA were found in 98% of 53 celiac patients (1st biopsy), in 81% of 16 celiac patients after gluten challenge, while high levels of these antibodies were not found in 200 patients on gluten-free diet. Moreover high levels of IgA-AGA were found in 29% of 48 patients with normal jejunal biopsy and in 4% of 1.824 patients with gastrointestinal problems other than celiac disease. Our results confirm the data report in literature about the sensibility and the specificity of the IgA-AGA dosage as a screening test for celiac disease, but the possibility of false pathological and false normal values confirms the intestinal biopsy, as the main procedure for the diagnosis of celiac disease.

Authors+Show Affiliations

Divisione di Gastroenterologia, Ospedale Bambino Gesù, Roma, Italia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

ita

PubMed ID

1488309

Citation

Papadatou, B, et al. "[IgA-class Antigliadin Antibodies in the Screening and Follow-up of Celiac Disease Patients]." La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics, vol. 14, no. 5, 1992, pp. 517-9.
Papadatou B, Ferretti F, Colistro F, et al. [IgA-class antigliadin antibodies in the screening and follow-up of celiac disease patients]. Pediatr Med Chir. 1992;14(5):517-9.
Papadatou, B., Ferretti, F., Colistro, F., Castellucci, G., Lucidi, V., Ricci, S., ... Gambarara, M. (1992). [IgA-class antigliadin antibodies in the screening and follow-up of celiac disease patients]. La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics, 14(5), pp. 517-9.
Papadatou B, et al. [IgA-class Antigliadin Antibodies in the Screening and Follow-up of Celiac Disease Patients]. Pediatr Med Chir. 1992;14(5):517-9. PubMed PMID: 1488309.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [IgA-class antigliadin antibodies in the screening and follow-up of celiac disease patients]. A1 - Papadatou,B, AU - Ferretti,F, AU - Colistro,F, AU - Castellucci,G, AU - Lucidi,V, AU - Ricci,S, AU - Cerminara,R, AU - Bella,S, AU - Colombo,A M, AU - Gambarara,M, PY - 1992/9/1/pubmed PY - 1992/9/1/medline PY - 1992/9/1/entrez SP - 517 EP - 9 JF - La Pediatria medica e chirurgica : Medical and surgical pediatrics JO - Pediatr Med Chir VL - 14 IS - 5 N2 - IgA antigliadin antibodies (IgA-AGA) have been determined with an enzyme immunoassay in 2.141 pediatric patients. High levels of IgA were found in 98% of 53 celiac patients (1st biopsy), in 81% of 16 celiac patients after gluten challenge, while high levels of these antibodies were not found in 200 patients on gluten-free diet. Moreover high levels of IgA-AGA were found in 29% of 48 patients with normal jejunal biopsy and in 4% of 1.824 patients with gastrointestinal problems other than celiac disease. Our results confirm the data report in literature about the sensibility and the specificity of the IgA-AGA dosage as a screening test for celiac disease, but the possibility of false pathological and false normal values confirms the intestinal biopsy, as the main procedure for the diagnosis of celiac disease. SN - 0391-5387 UR - https://www.unboundmedicine.com/medline/citation/1488309/[IgA_class_antigliadin_antibodies_in_the_screening_and_follow_up_of_celiac_disease_patients]_ L2 - http://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -