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[The clinical and hemodynamic effects of propionyl-L-carnitine in the treatment of congestive heart failure].
Clin Ter. 1992 Nov; 141(11):379-84.CT

Abstract

In order to evaluate the clinical and hemodynamic effects of propionyl-L-carnitine (PLC) a randomized, double-blind study versus placebo was performed in 50 patients of both sexes, between 48 and 69 years of age, affected by mild-moderate congestive heart failure. All patients participating in said study were on digitalis and diuretic treatment. 25 of these belonged to the control group, while the other 25 were treated with an oral dose of 1 g b.i.d of propionyl-L-carnitine. At the end of six months of treatment maximum exercise time on the treadmill increased 11.1% after 90 days and 16.4% after 180 in the group treated with PLC. From a hemodynamic standpoint, after 30, 90 and 180 days the ejection fraction increased by 7.3%, 10.7% and 12.1%. At the same time, moreover, the systemic vascular resistances were reduced by 14.9%, 20% and 20.6%. In the patients treated with placebo, however, the above-mentioned parameters showed no significant variation. Finally, no unexpected events or toxic effects were observed in any of the patients in either group. As a consequence of these results it is possible to affirm that propionyl-L-carnitine, due to its clinical and hemodynamic effects, represents a drug of notable therapeutic interest in patients with congestive heart failure, in whom it may be usefully combined with the usual pharmacological therapy.

Authors+Show Affiliations

Servizio di Cardiologia, USL n. 42, Ospedale Elena D'Aosta, Napoli.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

ita

PubMed ID

1493661

Citation

Pucciarelli, G, et al. "[The Clinical and Hemodynamic Effects of propionyl-L-carnitine in the Treatment of Congestive Heart Failure]." La Clinica Terapeutica, vol. 141, no. 11, 1992, pp. 379-84.
Pucciarelli G, Mastursi M, Latte S, et al. [The clinical and hemodynamic effects of propionyl-L-carnitine in the treatment of congestive heart failure]. Clin Ter. 1992;141(11):379-84.
Pucciarelli, G., Mastursi, M., Latte, S., Sacra, C., Setaro, A., Lizzadro, A., & Nolfe, G. (1992). [The clinical and hemodynamic effects of propionyl-L-carnitine in the treatment of congestive heart failure]. La Clinica Terapeutica, 141(11), 379-84.
Pucciarelli G, et al. [The Clinical and Hemodynamic Effects of propionyl-L-carnitine in the Treatment of Congestive Heart Failure]. Clin Ter. 1992;141(11):379-84. PubMed PMID: 1493661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The clinical and hemodynamic effects of propionyl-L-carnitine in the treatment of congestive heart failure]. AU - Pucciarelli,G, AU - Mastursi,M, AU - Latte,S, AU - Sacra,C, AU - Setaro,A, AU - Lizzadro,A, AU - Nolfe,G, PY - 1992/11/1/pubmed PY - 1992/11/1/medline PY - 1992/11/1/entrez SP - 379 EP - 84 JF - La Clinica terapeutica JO - Clin Ter VL - 141 IS - 11 N2 - In order to evaluate the clinical and hemodynamic effects of propionyl-L-carnitine (PLC) a randomized, double-blind study versus placebo was performed in 50 patients of both sexes, between 48 and 69 years of age, affected by mild-moderate congestive heart failure. All patients participating in said study were on digitalis and diuretic treatment. 25 of these belonged to the control group, while the other 25 were treated with an oral dose of 1 g b.i.d of propionyl-L-carnitine. At the end of six months of treatment maximum exercise time on the treadmill increased 11.1% after 90 days and 16.4% after 180 in the group treated with PLC. From a hemodynamic standpoint, after 30, 90 and 180 days the ejection fraction increased by 7.3%, 10.7% and 12.1%. At the same time, moreover, the systemic vascular resistances were reduced by 14.9%, 20% and 20.6%. In the patients treated with placebo, however, the above-mentioned parameters showed no significant variation. Finally, no unexpected events or toxic effects were observed in any of the patients in either group. As a consequence of these results it is possible to affirm that propionyl-L-carnitine, due to its clinical and hemodynamic effects, represents a drug of notable therapeutic interest in patients with congestive heart failure, in whom it may be usefully combined with the usual pharmacological therapy. SN - 0009-9074 UR - https://www.unboundmedicine.com/medline/citation/1493661/[The_clinical_and_hemodynamic_effects_of_propionyl_L_carnitine_in_the_treatment_of_congestive_heart_failure]_ L2 - https://medlineplus.gov/heartfailure.html DB - PRIME DP - Unbound Medicine ER -