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Raynaud's features in childhood. Clinical, immunological and capillaroscopic study.
J Mal Vasc. 1992; 17(4):273-6.JM

Abstract

Raynaud's phenomenon, uncommon in childhood, often heralds connective tissue disorder. Since microvascular abnormalities can be detected at an early stage of the connective tissue disease, especially in scleroderma, a specific diagnosis can be made in patients presenting with Raynaud's phenomenon alone or Raynaud's phenomenon associated with symptoms suggestive of connective tissue disease. Raynaud's phenomenon was studied in 11 consecutive children, 10 girls and 1 boy, ages 6 to 15. One child had a definite diagnosis of cutaneous polyarteritis nodosa. In 6 others connective tissue disease was suspected: 4 had arthritis, 2 has telangiectasia, leg ulcers and antinuclear antibodies. Of the remaining 4, one had hemiplegia and 3 Raynaud's phenomenon only. Oscillometry of the radial artery was reduced in 7 of 9. Decreased capillary resistance was found in 2 of 6, while abrupt thinning in conjunctival vessels was seen in 3 of 7. On nailfold capillaroscopy, reduced vascularity was noted in 5 of 11, dilated capillaries in 4 of 11, tortuousity in 2 of 11, capillary thinning in 1 of 11, capillary spasm in 1 of 11 and normal pattern in 3 of 11. Two patients presenting with Raynaud's phenomenon were found to have "scleroderma-like pattern" on nailfold capillaroscopy. One of them died 2 years later of cardiopulmonary sclerosis, and another developed esophageal stricture and Barrett's esophagus. Neither has sclerodermatous skin. In childhood Raynaud's phenomenon, nailfold capillaroscopy is a non-invasive examination enabling early diagnosis of "systemic scleroderma sine scleroderma".

Authors+Show Affiliations

Department of Pediatrics, Bikur-Cholim General Hospital, Jerusalem, Israel.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1494054

Citation

Navon, P, et al. "Raynaud's Features in Childhood. Clinical, Immunological and Capillaroscopic Study." Journal Des Maladies Vasculaires, vol. 17, no. 4, 1992, pp. 273-6.
Navon P, Yarom A, Davis E. Raynaud's features in childhood. Clinical, immunological and capillaroscopic study. J Mal Vasc. 1992;17(4):273-6.
Navon, P., Yarom, A., & Davis, E. (1992). Raynaud's features in childhood. Clinical, immunological and capillaroscopic study. Journal Des Maladies Vasculaires, 17(4), 273-6.
Navon P, Yarom A, Davis E. Raynaud's Features in Childhood. Clinical, Immunological and Capillaroscopic Study. J Mal Vasc. 1992;17(4):273-6. PubMed PMID: 1494054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Raynaud's features in childhood. Clinical, immunological and capillaroscopic study. AU - Navon,P, AU - Yarom,A, AU - Davis,E, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 273 EP - 6 JF - Journal des maladies vasculaires JO - J Mal Vasc VL - 17 IS - 4 N2 - Raynaud's phenomenon, uncommon in childhood, often heralds connective tissue disorder. Since microvascular abnormalities can be detected at an early stage of the connective tissue disease, especially in scleroderma, a specific diagnosis can be made in patients presenting with Raynaud's phenomenon alone or Raynaud's phenomenon associated with symptoms suggestive of connective tissue disease. Raynaud's phenomenon was studied in 11 consecutive children, 10 girls and 1 boy, ages 6 to 15. One child had a definite diagnosis of cutaneous polyarteritis nodosa. In 6 others connective tissue disease was suspected: 4 had arthritis, 2 has telangiectasia, leg ulcers and antinuclear antibodies. Of the remaining 4, one had hemiplegia and 3 Raynaud's phenomenon only. Oscillometry of the radial artery was reduced in 7 of 9. Decreased capillary resistance was found in 2 of 6, while abrupt thinning in conjunctival vessels was seen in 3 of 7. On nailfold capillaroscopy, reduced vascularity was noted in 5 of 11, dilated capillaries in 4 of 11, tortuousity in 2 of 11, capillary thinning in 1 of 11, capillary spasm in 1 of 11 and normal pattern in 3 of 11. Two patients presenting with Raynaud's phenomenon were found to have "scleroderma-like pattern" on nailfold capillaroscopy. One of them died 2 years later of cardiopulmonary sclerosis, and another developed esophageal stricture and Barrett's esophagus. Neither has sclerodermatous skin. In childhood Raynaud's phenomenon, nailfold capillaroscopy is a non-invasive examination enabling early diagnosis of "systemic scleroderma sine scleroderma". SN - 0398-0499 UR - https://www.unboundmedicine.com/medline/citation/1494054/Raynaud's_features_in_childhood__Clinical_immunological_and_capillaroscopic_study_ L2 - https://medlineplus.gov/raynaudsdisease.html DB - PRIME DP - Unbound Medicine ER -