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Papillary serous adenocarcinoma of the uterine cervix: a report of three cases.
Mod Pathol. 1992 Jul; 5(4):426-31.MP

Abstract

Three cases of primary papillary serous adenocarcinoma of the uterine cervix, the first described in detail at this site, are reported. Two women, 32 and 33 years of age, presented with postcoital spotting. The third patient, a 69-year-old asymptomatic woman, had abnormal cells on a routine cervical Papanicolaou smear. There was no evidence of extracervical spread on physical examination in any of the cases, but computed tomographic scan of the abdomen revealed retroperitoneal lymphadenopathy in one patient. Two patients, one treated by preoperative radiation and cervicectomy and the other by radical hysterectomy and postoperative radiation, are alive and well 5 years later. The third patient underwent cone biopsy and is currently completing chemotherapy to be followed by radiation therapy. On gross examination, the tumors were indistinguishable from typical endocervical adenocarcinoma. Microscopic examination revealed high-grade papillary serous adenocarcinoma in each case; in one tumor, there was a minor admixed component of low-grade villoglandular papillary adenocarcinoma. Although none of the tumors was deeply invasive, pelvic nodal metastases were present in two cases. There was no evidence of endometrial, tubal, ovarian, or peritoneal tumor in any case. Papillary serous carcinomas should be distinguished from other papillary carcinomas of the cervix, particularly the recently described low-grade papillary villoglandular adenocarcinoma, a variant of endocervical adenocarcinoma with a good prognosis.

Authors+Show Affiliations

Department of Pathology, University Hospital, Vancouver, Canada.No affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

1495949

Citation

Gilks, C B., and P B. Clement. "Papillary Serous Adenocarcinoma of the Uterine Cervix: a Report of Three Cases." Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, vol. 5, no. 4, 1992, pp. 426-31.
Gilks CB, Clement PB. Papillary serous adenocarcinoma of the uterine cervix: a report of three cases. Mod Pathol. 1992;5(4):426-31.
Gilks, C. B., & Clement, P. B. (1992). Papillary serous adenocarcinoma of the uterine cervix: a report of three cases. Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 5(4), 426-31.
Gilks CB, Clement PB. Papillary Serous Adenocarcinoma of the Uterine Cervix: a Report of Three Cases. Mod Pathol. 1992;5(4):426-31. PubMed PMID: 1495949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Papillary serous adenocarcinoma of the uterine cervix: a report of three cases. AU - Gilks,C B, AU - Clement,P B, PY - 1992/7/1/pubmed PY - 1992/7/1/medline PY - 1992/7/1/entrez SP - 426 EP - 31 JF - Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc JO - Mod Pathol VL - 5 IS - 4 N2 - Three cases of primary papillary serous adenocarcinoma of the uterine cervix, the first described in detail at this site, are reported. Two women, 32 and 33 years of age, presented with postcoital spotting. The third patient, a 69-year-old asymptomatic woman, had abnormal cells on a routine cervical Papanicolaou smear. There was no evidence of extracervical spread on physical examination in any of the cases, but computed tomographic scan of the abdomen revealed retroperitoneal lymphadenopathy in one patient. Two patients, one treated by preoperative radiation and cervicectomy and the other by radical hysterectomy and postoperative radiation, are alive and well 5 years later. The third patient underwent cone biopsy and is currently completing chemotherapy to be followed by radiation therapy. On gross examination, the tumors were indistinguishable from typical endocervical adenocarcinoma. Microscopic examination revealed high-grade papillary serous adenocarcinoma in each case; in one tumor, there was a minor admixed component of low-grade villoglandular papillary adenocarcinoma. Although none of the tumors was deeply invasive, pelvic nodal metastases were present in two cases. There was no evidence of endometrial, tubal, ovarian, or peritoneal tumor in any case. Papillary serous carcinomas should be distinguished from other papillary carcinomas of the cervix, particularly the recently described low-grade papillary villoglandular adenocarcinoma, a variant of endocervical adenocarcinoma with a good prognosis. SN - 0893-3952 UR - https://www.unboundmedicine.com/medline/citation/1495949/Papillary_serous_adenocarcinoma_of_the_uterine_cervix:_a_report_of_three_cases_ L2 - https://screening.iarc.fr/atlashisto.php DB - PRIME DP - Unbound Medicine ER -
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