Enantioselective aza-Henry reaction catalyzed by a bifunctional organocatalyst.Org Lett. 2004 Feb 19; 6(4):625-7.OL
[reaction: see text] The aza-Henry reaction of imines with nitroalkanes was promoted by chiral thiourea with an N,N-dimethylamino group to give beta-nitroamines with good enantioselectivity. Various N-protected imines were examined as substrates. N-Phosphinoylimine gave the best result in terms of chemical yield and enantioselectivity (up to 91% yield, up to 76% ee).