Tags

Type your tag names separated by a space and hit enter

Diets rich in saturated and polyunsaturated fatty acids: metabolic shifting and cardiac health.
Nutrition. 2004 Feb; 20(2):230-4.N

Abstract

OBJECTIVE

The aim of this study was to determine the effects of diets rich in saturated and polyunsaturated fatty acids on metabolic pathways and the relation of metabolic shifting to oxidative stress in cardiac tissue.

METHODS

Male Wistar rats (age, 60 d; n = 10) were fed with a control low-fat diet, a diet rich in saturated fatty acids (SFAs), or a diet rich in polyunsaturated fatty acids (PUFAs). After 5 wk of treatment, sera were used for protein and lipid determinations. Protein, glycogen, triacylglycerol, lactate dehydrogenase, citrate synthase, beta-hydroxyacyl coenzyme-A dehydrogenase, catalase, glutathione peroxidase, superoxide dismutase, lipoperoxide, and lipid hydroperoxide were measured in cardiac tissue.

RESULTS

The SFA group had higher triacylglycerol, cholesterol, low-density lipoprotein cholesterol, and atherogenic index (ratio of cholesterol to high-density lipoprotein) than did the PUFA and control groups. The PUFA group had low serum cholesterol, triacylglycerol, and low-density lipoprotein cholesterol as compared with the SFA group. SFA increased myocardial lipid hydroperoxide and diminished glutathione peroxidase. Despite the beneficial effects on serum lipids, the PUFA diet led to the highest levels of myocardial lipoperoxide and lipid hydroperoxide and diminished superoxide dismutase and catalase activities. The PUFA effects were related to increased feed efficiency, increased susceptibility to lipoperoxidation, and metabolic shifting in cardiac tissue. PUFA elevated triacylglycerol levels and decreased myocardial glycogen concentrations. The ratios of lactate dehydrogenase to citrate synthase and beta-hydroxyacyl coenzyme-A dehydrogenase to citrate synthase were increased, indicating myocardial reduction of tricarboxylic acid cycle.

CONCLUSIONS

PUFAs have been recommended as a therapeutic measure in preventive medicine to lower serum cholesterol, but PUFAs increased oxidative stress in the heart by providing cardiac susceptibility to lipoperoxidation and shifting the metabolic pathway for energy production. The control diet, which was much lower in calories and fat, produced better overall clinical outcomes, better fat profiles, and less oxidative stress than did the diets rich in fatty acids.

Authors+Show Affiliations

Department of Clinical Cardiology, Faculty of Medicine, University of São Paulo State, Botucatu, São Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14962692

Citation

Diniz, Yeda Sant'Ana, et al. "Diets Rich in Saturated and Polyunsaturated Fatty Acids: Metabolic Shifting and Cardiac Health." Nutrition (Burbank, Los Angeles County, Calif.), vol. 20, no. 2, 2004, pp. 230-4.
Diniz YS, Cicogna AC, Padovani CR, et al. Diets rich in saturated and polyunsaturated fatty acids: metabolic shifting and cardiac health. Nutrition. 2004;20(2):230-4.
Diniz, Y. S., Cicogna, A. C., Padovani, C. R., Santana, L. S., Faine, L. A., & Novelli, E. L. (2004). Diets rich in saturated and polyunsaturated fatty acids: metabolic shifting and cardiac health. Nutrition (Burbank, Los Angeles County, Calif.), 20(2), 230-4.
Diniz YS, et al. Diets Rich in Saturated and Polyunsaturated Fatty Acids: Metabolic Shifting and Cardiac Health. Nutrition. 2004;20(2):230-4. PubMed PMID: 14962692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diets rich in saturated and polyunsaturated fatty acids: metabolic shifting and cardiac health. AU - Diniz,Yeda Sant'Ana, AU - Cicogna,Antonio C, AU - Padovani,Carlos R, AU - Santana,Lea S, AU - Faine,Luciane A, AU - Novelli,Ethel L B, PY - 2004/2/14/pubmed PY - 2004/8/25/medline PY - 2004/2/14/entrez SP - 230 EP - 4 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 20 IS - 2 N2 - OBJECTIVE: The aim of this study was to determine the effects of diets rich in saturated and polyunsaturated fatty acids on metabolic pathways and the relation of metabolic shifting to oxidative stress in cardiac tissue. METHODS: Male Wistar rats (age, 60 d; n = 10) were fed with a control low-fat diet, a diet rich in saturated fatty acids (SFAs), or a diet rich in polyunsaturated fatty acids (PUFAs). After 5 wk of treatment, sera were used for protein and lipid determinations. Protein, glycogen, triacylglycerol, lactate dehydrogenase, citrate synthase, beta-hydroxyacyl coenzyme-A dehydrogenase, catalase, glutathione peroxidase, superoxide dismutase, lipoperoxide, and lipid hydroperoxide were measured in cardiac tissue. RESULTS: The SFA group had higher triacylglycerol, cholesterol, low-density lipoprotein cholesterol, and atherogenic index (ratio of cholesterol to high-density lipoprotein) than did the PUFA and control groups. The PUFA group had low serum cholesterol, triacylglycerol, and low-density lipoprotein cholesterol as compared with the SFA group. SFA increased myocardial lipid hydroperoxide and diminished glutathione peroxidase. Despite the beneficial effects on serum lipids, the PUFA diet led to the highest levels of myocardial lipoperoxide and lipid hydroperoxide and diminished superoxide dismutase and catalase activities. The PUFA effects were related to increased feed efficiency, increased susceptibility to lipoperoxidation, and metabolic shifting in cardiac tissue. PUFA elevated triacylglycerol levels and decreased myocardial glycogen concentrations. The ratios of lactate dehydrogenase to citrate synthase and beta-hydroxyacyl coenzyme-A dehydrogenase to citrate synthase were increased, indicating myocardial reduction of tricarboxylic acid cycle. CONCLUSIONS: PUFAs have been recommended as a therapeutic measure in preventive medicine to lower serum cholesterol, but PUFAs increased oxidative stress in the heart by providing cardiac susceptibility to lipoperoxidation and shifting the metabolic pathway for energy production. The control diet, which was much lower in calories and fat, produced better overall clinical outcomes, better fat profiles, and less oxidative stress than did the diets rich in fatty acids. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/14962692/Diets_rich_in_saturated_and_polyunsaturated_fatty_acids:_metabolic_shifting_and_cardiac_health_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899900703002600 DB - PRIME DP - Unbound Medicine ER -