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Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development.
J Biol Chem. 2004 Apr 30; 279(18):19141-8.JB

Abstract

The dentin matrix protein-1 (DMP-1) gene is identified in odontoblasts during both embryonic and postnatal development. In vitro study suggests that this noncollagen acidic phosphoprotein plays a role in mineralization. However, deletion of the Dmp-1 gene has little effect on tooth development during embryogenesis. To address the role of DMP-1 in tooth during postnatal development, we analyzed changes of dentinogenesis in Dmp-1 null mice from 3 days after birth to 1 year. Here we show that Dmp-1 null mice postnatally develop a profound tooth phenotype characterized by a partial failure of maturation of predentin into dentin, enlarged pulp chambers, increased width of predentin zone with reduced dentin wall, and hypomineralization. The tooth phenotype of these mice is strikingly similar to that in dentin sialophosphoprotein (Dspp) null mice and shares some features of the human disease dentinogenesis imperfecta III. We have also demonstrated that DSPP levels are reduced in Dmp-1 null mice, suggesting that DSPP is probably regulated by DMP-1 during dentinogenesis. Finally, we show the absence or delayed development of the third molar in Dmp-1 null mice, which is probably secondary to defects in Dmp-1 null bone. Taken together, these studies suggest that DMP-1 is essential for later dentinogenesis during postnatal development.

Authors+Show Affiliations

Department of Oral Biology, School of Dentistry, University of Missouri-Kansas, City, Kansas City, Missouri 64108, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14966118

Citation

Ye, Ling, et al. "Deletion of Dentin Matrix Protein-1 Leads to a Partial Failure of Maturation of Predentin Into Dentin, Hypomineralization, and Expanded Cavities of Pulp and Root Canal During Postnatal Tooth Development." The Journal of Biological Chemistry, vol. 279, no. 18, 2004, pp. 19141-8.
Ye L, MacDougall M, Zhang S, et al. Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. J Biol Chem. 2004;279(18):19141-8.
Ye, L., MacDougall, M., Zhang, S., Xie, Y., Zhang, J., Li, Z., Lu, Y., Mishina, Y., & Feng, J. Q. (2004). Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. The Journal of Biological Chemistry, 279(18), 19141-8.
Ye L, et al. Deletion of Dentin Matrix Protein-1 Leads to a Partial Failure of Maturation of Predentin Into Dentin, Hypomineralization, and Expanded Cavities of Pulp and Root Canal During Postnatal Tooth Development. J Biol Chem. 2004 Apr 30;279(18):19141-8. PubMed PMID: 14966118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. AU - Ye,Ling, AU - MacDougall,Mary, AU - Zhang,Shubin, AU - Xie,Yixia, AU - Zhang,Jianghong, AU - Li,Zubing, AU - Lu,Yongbo, AU - Mishina,Yuji, AU - Feng,Jian Q, Y1 - 2004/02/13/ PY - 2004/2/18/pubmed PY - 2004/6/21/medline PY - 2004/2/18/entrez SP - 19141 EP - 8 JF - The Journal of biological chemistry JO - J Biol Chem VL - 279 IS - 18 N2 - The dentin matrix protein-1 (DMP-1) gene is identified in odontoblasts during both embryonic and postnatal development. In vitro study suggests that this noncollagen acidic phosphoprotein plays a role in mineralization. However, deletion of the Dmp-1 gene has little effect on tooth development during embryogenesis. To address the role of DMP-1 in tooth during postnatal development, we analyzed changes of dentinogenesis in Dmp-1 null mice from 3 days after birth to 1 year. Here we show that Dmp-1 null mice postnatally develop a profound tooth phenotype characterized by a partial failure of maturation of predentin into dentin, enlarged pulp chambers, increased width of predentin zone with reduced dentin wall, and hypomineralization. The tooth phenotype of these mice is strikingly similar to that in dentin sialophosphoprotein (Dspp) null mice and shares some features of the human disease dentinogenesis imperfecta III. We have also demonstrated that DSPP levels are reduced in Dmp-1 null mice, suggesting that DSPP is probably regulated by DMP-1 during dentinogenesis. Finally, we show the absence or delayed development of the third molar in Dmp-1 null mice, which is probably secondary to defects in Dmp-1 null bone. Taken together, these studies suggest that DMP-1 is essential for later dentinogenesis during postnatal development. SN - 0021-9258 UR - https://www.unboundmedicine.com/medline/citation/14966118/Deletion_of_dentin_matrix_protein_1_leads_to_a_partial_failure_of_maturation_of_predentin_into_dentin_hypomineralization_and_expanded_cavities_of_pulp_and_root_canal_during_postnatal_tooth_development_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9258(19)75477-5 DB - PRIME DP - Unbound Medicine ER -