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New fragmentation mechanisms in matrix-assisted laser desorption/ionization time-of-flight/time-of-flight tandem mass spectrometry of carbohydrates.
Rapid Commun Mass Spectrom. 2004; 18(4):392-8.RC

Abstract

The spectra recorded by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight tandem mass spectrometry (MALDI-TOF/TOF-MS/MS) of complex carbohydrates from human milk are presented. Besides ions originating from glycosidic cleavages and from sugar ring fragmentations, these spectra show intense peaks that may be assigned to ions produced by three new fragmentation pathways involving a six-atom rearrangement. These ions, together with the A fragments from sugar ring fragmentations, open the possibility of obtaining a complete mapping of the linkage positions present in the carbohydrates investigated by MALDI-TOF/TOF.

Authors+Show Affiliations

CNR-Istituto di Chimica e Tecnologia dei Polimeri, V. le Regina Margherita 6, 95123 Catania, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14966845

Citation

Spina, Emanuela, et al. "New Fragmentation Mechanisms in Matrix-assisted Laser Desorption/ionization Time-of-flight/time-of-flight Tandem Mass Spectrometry of Carbohydrates." Rapid Communications in Mass Spectrometry : RCM, vol. 18, no. 4, 2004, pp. 392-8.
Spina E, Sturiale L, Romeo D, et al. New fragmentation mechanisms in matrix-assisted laser desorption/ionization time-of-flight/time-of-flight tandem mass spectrometry of carbohydrates. Rapid Commun Mass Spectrom. 2004;18(4):392-8.
Spina, E., Sturiale, L., Romeo, D., Impallomeni, G., Garozzo, D., Waidelich, D., & Glueckmann, M. (2004). New fragmentation mechanisms in matrix-assisted laser desorption/ionization time-of-flight/time-of-flight tandem mass spectrometry of carbohydrates. Rapid Communications in Mass Spectrometry : RCM, 18(4), 392-8.
Spina E, et al. New Fragmentation Mechanisms in Matrix-assisted Laser Desorption/ionization Time-of-flight/time-of-flight Tandem Mass Spectrometry of Carbohydrates. Rapid Commun Mass Spectrom. 2004;18(4):392-8. PubMed PMID: 14966845.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New fragmentation mechanisms in matrix-assisted laser desorption/ionization time-of-flight/time-of-flight tandem mass spectrometry of carbohydrates. AU - Spina,Emanuela, AU - Sturiale,Luisa, AU - Romeo,Donatella, AU - Impallomeni,Giuseppe, AU - Garozzo,Domenico, AU - Waidelich,Dietmar, AU - Glueckmann,Matthias, PY - 2004/2/18/pubmed PY - 2004/5/5/medline PY - 2004/2/18/entrez SP - 392 EP - 8 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 18 IS - 4 N2 - The spectra recorded by matrix-assisted laser desorption/ionization time-of-flight/time-of-flight tandem mass spectrometry (MALDI-TOF/TOF-MS/MS) of complex carbohydrates from human milk are presented. Besides ions originating from glycosidic cleavages and from sugar ring fragmentations, these spectra show intense peaks that may be assigned to ions produced by three new fragmentation pathways involving a six-atom rearrangement. These ions, together with the A fragments from sugar ring fragmentations, open the possibility of obtaining a complete mapping of the linkage positions present in the carbohydrates investigated by MALDI-TOF/TOF. SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/14966845/New_fragmentation_mechanisms_in_matrix_assisted_laser_desorption/ionization_time_of_flight/time_of_flight_tandem_mass_spectrometry_of_carbohydrates_ L2 - https://doi.org/10.1002/rcm.1350 DB - PRIME DP - Unbound Medicine ER -