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Glycosylated haemoglobin HbA1c and HbS1c in non-diabetic Nigerians.
Trop Geogr Med. 1992 Jan; 44(1-2):126-30.TG

Abstract

Normal glycosylated haemoglobin levels were determined by the Bio-Rad Haemoglobin A1c by Column Assay, in a large series of non-diabetic Nigerians. Subjects having normal haemoglobin genotype (HbAA) and the common haemoglobinopathies, namely heterozygous sickle cell trait (HbAS) and homozygous sickle-cell anaemia (HbSS) were studied. The group mean uncorrected %HbS1c levels in the HbSS subjects were significantly higher than %HbA1c levels in the HbAA (p less than 0.02) and HbAS (p less than 0.001). However, after correction for HbS and HbF the sickle-cell trait group had a %HbA1c value significantly higher than the %HbS1c value in the HbSS subjects (p less than 0.001). Since the haemoglobinopathies influence the glycosylated haemoglobin results, hence its interpretation, the need to correct observed results for the presence of abnormal haemoglobin has been emphasised. Only then would the application of a glycosylated haemoglobin test be truely meaningful in the management of diabetic patients with the 'S' haemoglobin.

Authors+Show Affiliations

Department of Physiology, School of Medicine, College of Medical Sciences, University of Benin, Nigeria.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1496704

Citation

Reid, H L., et al. "Glycosylated Haemoglobin HbA1c and HbS1c in Non-diabetic Nigerians." Tropical and Geographical Medicine, vol. 44, no. 1-2, 1992, pp. 126-30.
Reid HL, Famodu AA, Photiades DP, et al. Glycosylated haemoglobin HbA1c and HbS1c in non-diabetic Nigerians. Trop Geogr Med. 1992;44(1-2):126-30.
Reid, H. L., Famodu, A. A., Photiades, D. P., & Osamo, O. N. (1992). Glycosylated haemoglobin HbA1c and HbS1c in non-diabetic Nigerians. Tropical and Geographical Medicine, 44(1-2), 126-30.
Reid HL, et al. Glycosylated Haemoglobin HbA1c and HbS1c in Non-diabetic Nigerians. Trop Geogr Med. 1992;44(1-2):126-30. PubMed PMID: 1496704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycosylated haemoglobin HbA1c and HbS1c in non-diabetic Nigerians. AU - Reid,H L, AU - Famodu,A A, AU - Photiades,D P, AU - Osamo,O N, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 126 EP - 30 JF - Tropical and geographical medicine JO - Trop Geogr Med VL - 44 IS - 1-2 N2 - Normal glycosylated haemoglobin levels were determined by the Bio-Rad Haemoglobin A1c by Column Assay, in a large series of non-diabetic Nigerians. Subjects having normal haemoglobin genotype (HbAA) and the common haemoglobinopathies, namely heterozygous sickle cell trait (HbAS) and homozygous sickle-cell anaemia (HbSS) were studied. The group mean uncorrected %HbS1c levels in the HbSS subjects were significantly higher than %HbA1c levels in the HbAA (p less than 0.02) and HbAS (p less than 0.001). However, after correction for HbS and HbF the sickle-cell trait group had a %HbA1c value significantly higher than the %HbS1c value in the HbSS subjects (p less than 0.001). Since the haemoglobinopathies influence the glycosylated haemoglobin results, hence its interpretation, the need to correct observed results for the presence of abnormal haemoglobin has been emphasised. Only then would the application of a glycosylated haemoglobin test be truely meaningful in the management of diabetic patients with the 'S' haemoglobin. SN - 0041-3232 UR - https://www.unboundmedicine.com/medline/citation/1496704/Glycosylated_haemoglobin_HbA1c_and_HbS1c_in_non_diabetic_Nigerians_ L2 - https://medlineplus.gov/a1c.html DB - PRIME DP - Unbound Medicine ER -