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The direct catalytic asymmetric mannich reaction.
Acc Chem Res. 2004 Feb; 37(2):102-12.AC

Abstract

The direct catalytic asymmetric addition of unmodified carbonyl compounds to preformed or in situ-generated imines has emerged as a promising new route to optically enriched alpha- and beta-amino acid derivatives, beta-lactams, and 1,2- and gamma-amino alcohols. The direct catalytic asymmetric Mannich reactions are mediated by small organometallic and organic amine catalysts that can achieve levels of selectivity similar to those possible with natural enzymes. The different small-molecule catalysts described here are complementary in their applications. They also complement each other in syn or anti selectivity of the direct asymmetric Mannich reaction. In this Account, we highlight the recent developments in and contributions to this research.

Authors+Show Affiliations

Arrhenius Laboratory, Department of Organic Chemistry, Stockholm University, SE-10691 Stockholm, Sweden.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

14967057

Citation

Córdova, Armando. "The Direct Catalytic Asymmetric Mannich Reaction." Accounts of Chemical Research, vol. 37, no. 2, 2004, pp. 102-12.
Córdova A. The direct catalytic asymmetric mannich reaction. Acc Chem Res. 2004;37(2):102-12.
Córdova, A. (2004). The direct catalytic asymmetric mannich reaction. Accounts of Chemical Research, 37(2), 102-12.
Córdova A. The Direct Catalytic Asymmetric Mannich Reaction. Acc Chem Res. 2004;37(2):102-12. PubMed PMID: 14967057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The direct catalytic asymmetric mannich reaction. A1 - Córdova,Armando, PY - 2004/2/18/pubmed PY - 2004/3/16/medline PY - 2004/2/18/entrez SP - 102 EP - 12 JF - Accounts of chemical research JO - Acc Chem Res VL - 37 IS - 2 N2 - The direct catalytic asymmetric addition of unmodified carbonyl compounds to preformed or in situ-generated imines has emerged as a promising new route to optically enriched alpha- and beta-amino acid derivatives, beta-lactams, and 1,2- and gamma-amino alcohols. The direct catalytic asymmetric Mannich reactions are mediated by small organometallic and organic amine catalysts that can achieve levels of selectivity similar to those possible with natural enzymes. The different small-molecule catalysts described here are complementary in their applications. They also complement each other in syn or anti selectivity of the direct asymmetric Mannich reaction. In this Account, we highlight the recent developments in and contributions to this research. SN - 0001-4842 UR - https://www.unboundmedicine.com/medline/citation/14967057/The_direct_catalytic_asymmetric_mannich_reaction_ L2 - https://doi.org/10.1021/ar030231l DB - PRIME DP - Unbound Medicine ER -