Abstract
The direct catalytic asymmetric addition of unmodified carbonyl compounds to preformed or in situ-generated imines has emerged as a promising new route to optically enriched alpha- and beta-amino acid derivatives, beta-lactams, and 1,2- and gamma-amino alcohols. The direct catalytic asymmetric Mannich reactions are mediated by small organometallic and organic amine catalysts that can achieve levels of selectivity similar to those possible with natural enzymes. The different small-molecule catalysts described here are complementary in their applications. They also complement each other in syn or anti selectivity of the direct asymmetric Mannich reaction. In this Account, we highlight the recent developments in and contributions to this research.
TY - JOUR
T1 - The direct catalytic asymmetric mannich reaction.
A1 - Córdova,Armando,
PY - 2004/2/18/pubmed
PY - 2004/3/16/medline
PY - 2004/2/18/entrez
SP - 102
EP - 12
JF - Accounts of chemical research
JO - Acc Chem Res
VL - 37
IS - 2
N2 - The direct catalytic asymmetric addition of unmodified carbonyl compounds to preformed or in situ-generated imines has emerged as a promising new route to optically enriched alpha- and beta-amino acid derivatives, beta-lactams, and 1,2- and gamma-amino alcohols. The direct catalytic asymmetric Mannich reactions are mediated by small organometallic and organic amine catalysts that can achieve levels of selectivity similar to those possible with natural enzymes. The different small-molecule catalysts described here are complementary in their applications. They also complement each other in syn or anti selectivity of the direct asymmetric Mannich reaction. In this Account, we highlight the recent developments in and contributions to this research.
SN - 0001-4842
UR - https://www.unboundmedicine.com/medline/citation/14967057/The_direct_catalytic_asymmetric_mannich_reaction_
L2 - https://doi.org/10.1021/ar030231l
DB - PRIME
DP - Unbound Medicine
ER -