Tags

Type your tag names separated by a space and hit enter

Serum resistin levels in women with polycystic ovary syndrome.
Fertil Steril 2004; 81(2):361-6FS

Abstract

OBJECTIVE

To measure serum resistin levels in women with polycystic ovary syndrome (PCOS) and assess possible correlations of resistin to the hormonal and metabolic parameters of the syndrome.

DESIGN

Clinical study.

SETTING

University hospital.

PATIENT(S)

Ninety selected women were classified as follows: group I: 35 anovulatory women with PCOS (body mass index [BMI] >25 kg/m(2)); group II: 35 anovulatory women with PCOS (BMI <25 kg/m(2)); group III: 20 ovulating women (controls) without hyperandrogenemia (BMI <25 kg/m(2)); women of group III were volunteers.

INTERVENTION(S)

Blood samples were collected between the 3rd and the 6th day of the menstrual cycle of the ovulating women, and between the 3rd and the 6th day of a spontaneous bleeding of the anovulatory women, at 9 a.m., after an overnight fast.

MAIN OUTCOME MEASURE(S)

Serum levels of FSH, LH, PRL, 17alpha-hydroxyprogesterone, sex hormone-binding globulin, androgens, insulin, resistin, and glucose.

RESULT(S)

Resistin levels were found to be significantly increased in group I compared with those of group II and those of group III. No significant difference in resistin levels was found between groups II and III, despite significant differences in insulin levels and the glucose-to-insulin ratio. Multiple regression analysis showed that resistin levels do not correlate with any parameter independent of BMI.

CONCLUSION(S)

Based on the above findings, we presume that resistin is unlikely to be a major determining factor of PCOS-associated insulin resistance and is not actively involved in the pathogenesis of the syndrome.

Authors+Show Affiliations

Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece. argic@med.auth.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14967374

Citation

Panidis, Dimitrios, et al. "Serum Resistin Levels in Women With Polycystic Ovary Syndrome." Fertility and Sterility, vol. 81, no. 2, 2004, pp. 361-6.
Panidis D, Koliakos G, Kourtis A, et al. Serum resistin levels in women with polycystic ovary syndrome. Fertil Steril. 2004;81(2):361-6.
Panidis, D., Koliakos, G., Kourtis, A., Farmakiotis, D., Mouslech, T., & Rousso, D. (2004). Serum resistin levels in women with polycystic ovary syndrome. Fertility and Sterility, 81(2), pp. 361-6.
Panidis D, et al. Serum Resistin Levels in Women With Polycystic Ovary Syndrome. Fertil Steril. 2004;81(2):361-6. PubMed PMID: 14967374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum resistin levels in women with polycystic ovary syndrome. AU - Panidis,Dimitrios, AU - Koliakos,Georgios, AU - Kourtis,Anargyros, AU - Farmakiotis,Dimitrios, AU - Mouslech,Tzant, AU - Rousso,David, PY - 2003/01/30/received PY - 2003/06/17/revised PY - 2003/06/17/accepted PY - 2004/2/18/pubmed PY - 2004/3/25/medline PY - 2004/2/18/entrez SP - 361 EP - 6 JF - Fertility and sterility JO - Fertil. Steril. VL - 81 IS - 2 N2 - OBJECTIVE: To measure serum resistin levels in women with polycystic ovary syndrome (PCOS) and assess possible correlations of resistin to the hormonal and metabolic parameters of the syndrome. DESIGN: Clinical study. SETTING: University hospital. PATIENT(S): Ninety selected women were classified as follows: group I: 35 anovulatory women with PCOS (body mass index [BMI] >25 kg/m(2)); group II: 35 anovulatory women with PCOS (BMI <25 kg/m(2)); group III: 20 ovulating women (controls) without hyperandrogenemia (BMI <25 kg/m(2)); women of group III were volunteers. INTERVENTION(S): Blood samples were collected between the 3rd and the 6th day of the menstrual cycle of the ovulating women, and between the 3rd and the 6th day of a spontaneous bleeding of the anovulatory women, at 9 a.m., after an overnight fast. MAIN OUTCOME MEASURE(S): Serum levels of FSH, LH, PRL, 17alpha-hydroxyprogesterone, sex hormone-binding globulin, androgens, insulin, resistin, and glucose. RESULT(S): Resistin levels were found to be significantly increased in group I compared with those of group II and those of group III. No significant difference in resistin levels was found between groups II and III, despite significant differences in insulin levels and the glucose-to-insulin ratio. Multiple regression analysis showed that resistin levels do not correlate with any parameter independent of BMI. CONCLUSION(S): Based on the above findings, we presume that resistin is unlikely to be a major determining factor of PCOS-associated insulin resistance and is not actively involved in the pathogenesis of the syndrome. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/14967374/Serum_resistin_levels_in_women_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015028203027201 DB - PRIME DP - Unbound Medicine ER -