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Effects of alcohol consumption on female fertility during an 18-year period.

Abstract

OBJECTIVE

To investigate the long-term effects of alcohol consumption on female fertility.

DESIGN

Prospective study of a random sample of 7,393 women, selected from the 445,000 inhabitants of Stockholm County, Sweden, in 1969. Self-estimated alcohol consumption was obtained from postal questionnaires. Data on hospitalizations for pregnancy outcomes including infertility examinations were analyzed until 1987.

SETTING

Healthy women in Stockholm County, Sweden.

PATIENT(S)

Seven thousand three hundred ninety-three women in the age range 18-28 years.

MAIN OUTCOME MEASURE(S)

Rates of hospitalization for deliveries, miscarriages, legal abortions, extrauterine pregnancies, pelvic inflammatory disease, endometriosis, and infertility examinations were analyzed in relation to the intake of alcohol.

RESULT(S)

Two hundred fifty-two women underwent infertility examinations. High consumers had an increased risk for such examinations, as compared with moderate consumers: relative risk ratio (RR) = 1.59 (95% confidence interval [CI]: 1.09-2.31); and low consumers had a decreased risk (RR = 0.64; CI: 0.46-0.90). Moreover, for both high and low consumers we observed a significantly lower number of first and second partus. Rates of miscarriage, extrauterine pregnancy, and pelvic inflammatory disease did not differ between high and low consumers of alcohol.

CONCLUSION(S)

High alcohol consumption was associated with increased risk of infertility examinations at hospitals and with lower numbers of first and second partus. It may be important for the female partner in an infertile couple to limit alcohol intake or to not drink at all.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Family Medicine Stockholm, Department of Clinical Science, Karolinska Institutet, Stockholm, Sweden. jan.eggert@klinvet.ki.se

    ,

    Source

    Fertility and sterility 81:2 2004 Feb pg 379-83

    MeSH

    Adolescent
    Adult
    Alcohol Drinking
    Female
    Fertility
    Humans
    Infertility, Female
    Middle Aged
    Pregnancy
    Pregnancy Complications
    Pregnancy Outcome
    Pregnancy, Ectopic
    Sweden

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    14967377

    Citation

    Eggert, Jan, et al. "Effects of Alcohol Consumption On Female Fertility During an 18-year Period." Fertility and Sterility, vol. 81, no. 2, 2004, pp. 379-83.
    Eggert J, Theobald H, Engfeldt P. Effects of alcohol consumption on female fertility during an 18-year period. Fertil Steril. 2004;81(2):379-83.
    Eggert, J., Theobald, H., & Engfeldt, P. (2004). Effects of alcohol consumption on female fertility during an 18-year period. Fertility and Sterility, 81(2), pp. 379-83.
    Eggert J, Theobald H, Engfeldt P. Effects of Alcohol Consumption On Female Fertility During an 18-year Period. Fertil Steril. 2004;81(2):379-83. PubMed PMID: 14967377.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effects of alcohol consumption on female fertility during an 18-year period. AU - Eggert,Jan, AU - Theobald,Holger, AU - Engfeldt,Peter, PY - 2002/06/10/received PY - 2003/06/19/revised PY - 2003/06/19/accepted PY - 2004/2/18/pubmed PY - 2004/3/25/medline PY - 2004/2/18/entrez SP - 379 EP - 83 JF - Fertility and sterility JO - Fertil. Steril. VL - 81 IS - 2 N2 - OBJECTIVE: To investigate the long-term effects of alcohol consumption on female fertility. DESIGN: Prospective study of a random sample of 7,393 women, selected from the 445,000 inhabitants of Stockholm County, Sweden, in 1969. Self-estimated alcohol consumption was obtained from postal questionnaires. Data on hospitalizations for pregnancy outcomes including infertility examinations were analyzed until 1987. SETTING: Healthy women in Stockholm County, Sweden. PATIENT(S): Seven thousand three hundred ninety-three women in the age range 18-28 years. MAIN OUTCOME MEASURE(S): Rates of hospitalization for deliveries, miscarriages, legal abortions, extrauterine pregnancies, pelvic inflammatory disease, endometriosis, and infertility examinations were analyzed in relation to the intake of alcohol. RESULT(S): Two hundred fifty-two women underwent infertility examinations. High consumers had an increased risk for such examinations, as compared with moderate consumers: relative risk ratio (RR) = 1.59 (95% confidence interval [CI]: 1.09-2.31); and low consumers had a decreased risk (RR = 0.64; CI: 0.46-0.90). Moreover, for both high and low consumers we observed a significantly lower number of first and second partus. Rates of miscarriage, extrauterine pregnancy, and pelvic inflammatory disease did not differ between high and low consumers of alcohol. CONCLUSION(S): High alcohol consumption was associated with increased risk of infertility examinations at hospitals and with lower numbers of first and second partus. It may be important for the female partner in an infertile couple to limit alcohol intake or to not drink at all. SN - 0015-0282 UR - https://www.unboundmedicine.com/medline/citation/14967377/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015028203027171 DB - PRIME DP - Unbound Medicine ER -