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[Biological aspects of endometriosis in vitro fertilization].

Abstract

Rinsing cumulus oophorus after oocyte retrieval is routinely performed in our department in Lyon for in vitro fertilization procedures when ovarian endometriosis is suspected. The aim of this procedure is to remove factors which might alter oocyte and embryo quality and fertilization and pregnancy rates. These factors, such as Tumor Necrosis Factor alpha (TNFalpha) and reactive oxygen species are known to be surexpressed in endometriosis. Their effect is not exclusively on the development of the oocyte and embryo but also on fertilization and implantation. It has been demonstrated that peritoneal and follicular fluid contains some factors that interfere with effective gamete interaction, as it has been determined by an in vitro animal assay. Peritoneal fluid from patients with mild endometriosis has an increased activity of TNFalpha, interleukin-1 (IL-1), antibodies and reactive oxygen species. This observation might be of importance in explaining subfertility associated with early stages of endometriosis. Cumulus-oophorus rinsing after oocyte retrieval might help to remove these deleterious factors. IVF outcomes in women affecting by endometriosis seem to be similar after cumulus-oophorus rinsing, as compared to those of patients undergoing IVF for tubal-factor infertility. This rinsing procedure could also be usefull in women affected by unexplained infertility: peritoneal and follicular fluid of these women contains increased levels of TNFalpha and reactive oxygen species, like women affected by endometriosis.

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  • Authors+Show Affiliations

    Département de Médecine et Biologie de la Reproduction, Hôpital E.-Herriot, Lyon, France.

    Source

    MeSH

    Endometriosis
    Female
    Fertilization in Vitro
    Humans
    Infertility, Female
    Oocytes
    Oxidative Stress
    Therapeutic Irrigation
    Zona Pellucida

    Pub Type(s)

    English Abstract
    Journal Article
    Review

    Language

    fre

    PubMed ID

    14968070

    Citation

    Lornage, J. "[Biological Aspects of Endometriosis in Vitro Fertilization]." Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction, vol. 32, no. 8 Pt 2, 2003, pp. S48-50.
    Lornage J. [Biological aspects of endometriosis in vitro fertilization]. J Gynecol Obstet Biol Reprod (Paris). 2003;32(8 Pt 2):S48-50.
    Lornage, J. (2003). [Biological aspects of endometriosis in vitro fertilization]. Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction, 32(8 Pt 2), pp. S48-50.
    Lornage J. [Biological Aspects of Endometriosis in Vitro Fertilization]. J Gynecol Obstet Biol Reprod (Paris). 2003;32(8 Pt 2):S48-50. PubMed PMID: 14968070.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - [Biological aspects of endometriosis in vitro fertilization]. A1 - Lornage,J, PY - 2004/2/18/pubmed PY - 2004/5/12/medline PY - 2004/2/18/entrez SP - S48 EP - 50 JF - Journal de gynecologie, obstetrique et biologie de la reproduction JO - J Gynecol Obstet Biol Reprod (Paris) VL - 32 IS - 8 Pt 2 N2 - Rinsing cumulus oophorus after oocyte retrieval is routinely performed in our department in Lyon for in vitro fertilization procedures when ovarian endometriosis is suspected. The aim of this procedure is to remove factors which might alter oocyte and embryo quality and fertilization and pregnancy rates. These factors, such as Tumor Necrosis Factor alpha (TNFalpha) and reactive oxygen species are known to be surexpressed in endometriosis. Their effect is not exclusively on the development of the oocyte and embryo but also on fertilization and implantation. It has been demonstrated that peritoneal and follicular fluid contains some factors that interfere with effective gamete interaction, as it has been determined by an in vitro animal assay. Peritoneal fluid from patients with mild endometriosis has an increased activity of TNFalpha, interleukin-1 (IL-1), antibodies and reactive oxygen species. This observation might be of importance in explaining subfertility associated with early stages of endometriosis. Cumulus-oophorus rinsing after oocyte retrieval might help to remove these deleterious factors. IVF outcomes in women affecting by endometriosis seem to be similar after cumulus-oophorus rinsing, as compared to those of patients undergoing IVF for tubal-factor infertility. This rinsing procedure could also be usefull in women affected by unexplained infertility: peritoneal and follicular fluid of these women contains increased levels of TNFalpha and reactive oxygen species, like women affected by endometriosis. SN - 0368-2315 UR - https://www.unboundmedicine.com/medline/citation/14968070/[Biological_aspects_of_endometriosis_in_vitro_fertilization]_ L2 - http://www.em-consulte.com/retrieve/pii/MDOI-JGYN-12-2003-32-8-C2-0368-2315-101019-ART12 DB - PRIME DP - Unbound Medicine ER -