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Efficacy of chlorhexidine gluconate rinse for treatment and prevention of oral candidiasis in HIV-infected children: a pilot study.

Abstract

PURPOSE

We evaluated the effect of chlorhexidine (CHX) 0.12% rinses on the clinical and microbiologic manifestations of oral candidiasis in HIV-infected children.

STUDY DESIGN

This was a cross-sectional, clinical intervention study of 38 HIV-positive children. Inclusion in the study was based on oral examination and positive oral culture for Candida. At baseline, subjects with no clinical lesions but who were culture-positive for Candida (N = 9) were placed on preventive therapy of CHX q.d. for 90 days. Subjects with clinical oral candidiasis (N = 9) were placed on therapeutic CHX b.i.d. All 38 subjects received oral exams at monthly intervals. At 90 days oral mucosal samples were again taken for Candida. Colony-forming units (CFU) were determined before and after CHX treatment.

RESULTS

Of 18 culture-positive subjects, 12 were included in the CFU analyses. After 3 months of CHX oral rinse therapy, Candida was undetectable in 3 children; another 8 showed an average 2-fold reduction in CFU. In 1 child the number of CFU increased modestly. Overall, the average pre- and posttreatment mean CFU was 6.18 +/- 2.19 and 2.73 +/- 3.15, respectively (P = .009). Five patients with clinical oral candidiasis at baseline, including all 3 who had pseudomembranous candidiasis, were free of signs of disease at the end of the study.

CONCLUSIONS

This study suggests that the topical disinfectant CHX may be a promising agent for treating and preventing oral candidiasis in HIV-infected children.

Authors+Show Affiliations

Department of Diagnostic Sciences, University of Detroit Mercy School of Dentistry, Detroit, MI 48219-0900, USA. barascan@udmercy.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14970779

Citation

Barasch, Andrei, et al. "Efficacy of Chlorhexidine Gluconate Rinse for Treatment and Prevention of Oral Candidiasis in HIV-infected Children: a Pilot Study." Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, vol. 97, no. 2, 2004, pp. 204-7.
Barasch A, Safford MM, Dapkute-Marcus I, et al. Efficacy of chlorhexidine gluconate rinse for treatment and prevention of oral candidiasis in HIV-infected children: a pilot study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97(2):204-7.
Barasch, A., Safford, M. M., Dapkute-Marcus, I., & Fine, D. H. (2004). Efficacy of chlorhexidine gluconate rinse for treatment and prevention of oral candidiasis in HIV-infected children: a pilot study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 97(2), 204-7.
Barasch A, et al. Efficacy of Chlorhexidine Gluconate Rinse for Treatment and Prevention of Oral Candidiasis in HIV-infected Children: a Pilot Study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;97(2):204-7. PubMed PMID: 14970779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of chlorhexidine gluconate rinse for treatment and prevention of oral candidiasis in HIV-infected children: a pilot study. AU - Barasch,Andrei, AU - Safford,Monika M, AU - Dapkute-Marcus,Ingrida, AU - Fine,Daniel H, PY - 2004/2/19/pubmed PY - 2004/4/2/medline PY - 2004/2/19/entrez SP - 204 EP - 7 JF - Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics JO - Oral Surg Oral Med Oral Pathol Oral Radiol Endod VL - 97 IS - 2 N2 - PURPOSE: We evaluated the effect of chlorhexidine (CHX) 0.12% rinses on the clinical and microbiologic manifestations of oral candidiasis in HIV-infected children. STUDY DESIGN: This was a cross-sectional, clinical intervention study of 38 HIV-positive children. Inclusion in the study was based on oral examination and positive oral culture for Candida. At baseline, subjects with no clinical lesions but who were culture-positive for Candida (N = 9) were placed on preventive therapy of CHX q.d. for 90 days. Subjects with clinical oral candidiasis (N = 9) were placed on therapeutic CHX b.i.d. All 38 subjects received oral exams at monthly intervals. At 90 days oral mucosal samples were again taken for Candida. Colony-forming units (CFU) were determined before and after CHX treatment. RESULTS: Of 18 culture-positive subjects, 12 were included in the CFU analyses. After 3 months of CHX oral rinse therapy, Candida was undetectable in 3 children; another 8 showed an average 2-fold reduction in CFU. In 1 child the number of CFU increased modestly. Overall, the average pre- and posttreatment mean CFU was 6.18 +/- 2.19 and 2.73 +/- 3.15, respectively (P = .009). Five patients with clinical oral candidiasis at baseline, including all 3 who had pseudomembranous candidiasis, were free of signs of disease at the end of the study. CONCLUSIONS: This study suggests that the topical disinfectant CHX may be a promising agent for treating and preventing oral candidiasis in HIV-infected children. SN - 1079-2104 UR - https://www.unboundmedicine.com/medline/citation/14970779/Efficacy_of_chlorhexidine_gluconate_rinse_for_treatment_and_prevention_of_oral_candidiasis_in_HIV_infected_children:_a_pilot_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1079210403005651 DB - PRIME DP - Unbound Medicine ER -