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Opposite effect of methionine-supplemented diet, a model of hyperhomocysteinemia, on plasma and liver antioxidant status in normotensive and spontaneously hypertensive rats.
J Nutr Biochem. 2004 Feb; 15(2):80-9.JN

Abstract

Hyperhomocysteinemia is often associated with an increase in blood pressure. However our previous study has shown that methionine supplementation induced an increase in blood pressure in Wistar-Kyoto (WKY) rats and a decrease in blood pressure in spontaneously hypertensive rats (SHR) with significant differences in plasma homocysteine (Hcy) metabolites levels. Previously liver antioxidant status has been shown to be decreased in SHR compared to WKY rats. It has been suggested that oxidative stress may predispose to a decrease in NO bioavailability and induce the flux of Hcy through the liver transsulfuration pathway. Thus the aim of this study was 1) to investigate the effect of methionine supplementation on NO-derived metabolites in plasma and urine 2) to investigate whether abnormalities in Hcy metabolism may be responsible for the discrepancies observed between WKY rats and SHR concerning blood pressure and 3) to investigate whether a methionine-enriched diet, differently modified plasma and liver antioxidant status in WKY rats an SHR. We conclude that the increase in blood pressure in WKY rats is related to high plasma cysteine levels and is not due to a decrease in NO bioavailability and that the decrease in blood pressure in SHR is associated with high plasma GSH levels after methionine supplementation. So GSH synthesis appears to be stimulated by liver oxidative stress and GSH is redistributed into blood in SHR. So the great GSH synthesis can be rationalized as an autocorrective response that leads to a decreased blood pressure in SHR.

Authors+Show Affiliations

Laboratoire de Physiologie, Pharmacologie et Nutrition Préventive Expérimentale, Besançon, France. ROBINRobinsophie@aol.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14972347

Citation

Robin, Sophie, et al. "Opposite Effect of Methionine-supplemented Diet, a Model of Hyperhomocysteinemia, On Plasma and Liver Antioxidant Status in Normotensive and Spontaneously Hypertensive Rats." The Journal of Nutritional Biochemistry, vol. 15, no. 2, 2004, pp. 80-9.
Robin S, Courderot-Masuyer C, Nicod L, et al. Opposite effect of methionine-supplemented diet, a model of hyperhomocysteinemia, on plasma and liver antioxidant status in normotensive and spontaneously hypertensive rats. J Nutr Biochem. 2004;15(2):80-9.
Robin, S., Courderot-Masuyer, C., Nicod, L., Jacqueson, A., Richert, L., & Berthelot, A. (2004). Opposite effect of methionine-supplemented diet, a model of hyperhomocysteinemia, on plasma and liver antioxidant status in normotensive and spontaneously hypertensive rats. The Journal of Nutritional Biochemistry, 15(2), 80-9.
Robin S, et al. Opposite Effect of Methionine-supplemented Diet, a Model of Hyperhomocysteinemia, On Plasma and Liver Antioxidant Status in Normotensive and Spontaneously Hypertensive Rats. J Nutr Biochem. 2004;15(2):80-9. PubMed PMID: 14972347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Opposite effect of methionine-supplemented diet, a model of hyperhomocysteinemia, on plasma and liver antioxidant status in normotensive and spontaneously hypertensive rats. AU - Robin,Sophie, AU - Courderot-Masuyer,Carol, AU - Nicod,Laurence, AU - Jacqueson,Alain, AU - Richert,Lysiane, AU - Berthelot,Alain, PY - 2002/01/03/received PY - 2004/2/20/pubmed PY - 2004/9/17/medline PY - 2004/2/20/entrez SP - 80 EP - 9 JF - The Journal of nutritional biochemistry JO - J Nutr Biochem VL - 15 IS - 2 N2 - Hyperhomocysteinemia is often associated with an increase in blood pressure. However our previous study has shown that methionine supplementation induced an increase in blood pressure in Wistar-Kyoto (WKY) rats and a decrease in blood pressure in spontaneously hypertensive rats (SHR) with significant differences in plasma homocysteine (Hcy) metabolites levels. Previously liver antioxidant status has been shown to be decreased in SHR compared to WKY rats. It has been suggested that oxidative stress may predispose to a decrease in NO bioavailability and induce the flux of Hcy through the liver transsulfuration pathway. Thus the aim of this study was 1) to investigate the effect of methionine supplementation on NO-derived metabolites in plasma and urine 2) to investigate whether abnormalities in Hcy metabolism may be responsible for the discrepancies observed between WKY rats and SHR concerning blood pressure and 3) to investigate whether a methionine-enriched diet, differently modified plasma and liver antioxidant status in WKY rats an SHR. We conclude that the increase in blood pressure in WKY rats is related to high plasma cysteine levels and is not due to a decrease in NO bioavailability and that the decrease in blood pressure in SHR is associated with high plasma GSH levels after methionine supplementation. So GSH synthesis appears to be stimulated by liver oxidative stress and GSH is redistributed into blood in SHR. So the great GSH synthesis can be rationalized as an autocorrective response that leads to a decreased blood pressure in SHR. SN - 0955-2863 UR - https://www.unboundmedicine.com/medline/citation/14972347/Opposite_effect_of_methionine_supplemented_diet_a_model_of_hyperhomocysteinemia_on_plasma_and_liver_antioxidant_status_in_normotensive_and_spontaneously_hypertensive_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955286303001669 DB - PRIME DP - Unbound Medicine ER -