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Metformin attenuates blood lipid peroxidation and potentiates antioxidant defense in high fructose-fed rats.
J Biochem Mol Biol Biophys. 2002 Dec; 6(6):379-85.JB

Abstract

The implication of oxidative stress in the pathology of insulin resistance has been shown recently. We investigated the effect of an insulin sensitizer, metformin, on the plasma lipid peroxidation and antioxidant defense system in the erythrocytes of high fructose fed rats which form an animal model of insulin resistance. The experimental animals were divided into two batches of 12 animals each. The control batch received the control diet, containing starch; the fructose group was given the high fructose diet. At the end of second week these were subdivided into two groups; one was given metformin (50 mg/kg/day in water) by gastric intubation and other group was left untreated. The rats were continued on the same dietary regimen for the next two weeks. Fructose-fed rats showed hyperglycemia, hyperinsulinemia and hypertriglyceridemia at the end of four weeks. Enhanced plasma lipid peroxidation and inadequate cellular antioxidant defense system were observed in them. Administration of metformin was associated with significant normalization of circulating insulin, glucose and triglyceride concentrations. The abnormal triglyceride distribution in the lipoprotein fractions was also ameliorated by metformin therapy. The imbalance between peroxidation and antioxidant defense system was mitigated when fructose-fed rats were treated with metformin. In the control rats, metformin did not affect the parameters studied. Significant positive correlation was obtained between insulin, triglycerides and glucose concentrations with lipid hydroperoxides suggesting that these metabolic variables could influence the lipid peroxide levels in plasma.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

14972791

Citation

Srividhya, S, et al. "Metformin Attenuates Blood Lipid Peroxidation and Potentiates Antioxidant Defense in High Fructose-fed Rats." Journal of Biochemistry, Molecular Biology, and Biophysics : JBMBB : the Official Journal of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB), vol. 6, no. 6, 2002, pp. 379-85.
Srividhya S, Ravichandran MK, Anuradha CV. Metformin attenuates blood lipid peroxidation and potentiates antioxidant defense in high fructose-fed rats. J Biochem Mol Biol Biophys. 2002;6(6):379-85.
Srividhya, S., Ravichandran, M. K., & Anuradha, C. V. (2002). Metformin attenuates blood lipid peroxidation and potentiates antioxidant defense in high fructose-fed rats. Journal of Biochemistry, Molecular Biology, and Biophysics : JBMBB : the Official Journal of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB), 6(6), 379-85.
Srividhya S, Ravichandran MK, Anuradha CV. Metformin Attenuates Blood Lipid Peroxidation and Potentiates Antioxidant Defense in High Fructose-fed Rats. J Biochem Mol Biol Biophys. 2002;6(6):379-85. PubMed PMID: 14972791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metformin attenuates blood lipid peroxidation and potentiates antioxidant defense in high fructose-fed rats. AU - Srividhya,S, AU - Ravichandran,M K, AU - Anuradha,C V, PY - 2004/2/20/pubmed PY - 2004/4/30/medline PY - 2004/2/20/entrez SP - 379 EP - 85 JF - Journal of biochemistry, molecular biology, and biophysics : JBMBB : the official journal of the Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB) JO - J Biochem Mol Biol Biophys VL - 6 IS - 6 N2 - The implication of oxidative stress in the pathology of insulin resistance has been shown recently. We investigated the effect of an insulin sensitizer, metformin, on the plasma lipid peroxidation and antioxidant defense system in the erythrocytes of high fructose fed rats which form an animal model of insulin resistance. The experimental animals were divided into two batches of 12 animals each. The control batch received the control diet, containing starch; the fructose group was given the high fructose diet. At the end of second week these were subdivided into two groups; one was given metformin (50 mg/kg/day in water) by gastric intubation and other group was left untreated. The rats were continued on the same dietary regimen for the next two weeks. Fructose-fed rats showed hyperglycemia, hyperinsulinemia and hypertriglyceridemia at the end of four weeks. Enhanced plasma lipid peroxidation and inadequate cellular antioxidant defense system were observed in them. Administration of metformin was associated with significant normalization of circulating insulin, glucose and triglyceride concentrations. The abnormal triglyceride distribution in the lipoprotein fractions was also ameliorated by metformin therapy. The imbalance between peroxidation and antioxidant defense system was mitigated when fructose-fed rats were treated with metformin. In the control rats, metformin did not affect the parameters studied. Significant positive correlation was obtained between insulin, triglycerides and glucose concentrations with lipid hydroperoxides suggesting that these metabolic variables could influence the lipid peroxide levels in plasma. SN - 1025-8140 UR - https://www.unboundmedicine.com/medline/citation/14972791/Metformin_attenuates_blood_lipid_peroxidation_and_potentiates_antioxidant_defense_in_high_fructose_fed_rats_ DB - PRIME DP - Unbound Medicine ER -