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[Hemodynamic and renal adaptation of newborn infants of hypertensive mothers treated with acebutolol].
Arch Fr Pediatr. 1992 Apr; 49(4):351-5.AF

Abstract

A prospective study of the hemodynamic and renal changes was undertaken in 11 neonates whose mothers were treated with acebutolol for hypertension during pregnancy, compared with a control group of 11 infants born to normotensive mothers. Monitoring of the cardio-respiratory system was performed for a period of 4 days. Renal function was studied during 2 periods (12-36, 60-84 hours of life). Hemodynamic failure was observed in 5 of 11 children from treated mothers. The data concerning the renal function of treated group showed: 1) a diuresis significantly lower during the first period (p less than 0.05); 2) the absence of significant rise in the glomerular filtration rates during the second period; 3) a lower sodium balance during the 1st and 2nd periods (p less than 0.02 and p less than 0.05), a lower calcium balance during the 1st period (p less than 0.01). No relationship was found between the renal changes and the hemodynamic disturbances. The direct effect of the drug on the glomerular and tubular functions and/or the renal arteriolar vasomotricity could explain these changes in the renal function in the newborns prenatally exposed to acebutolol.

Authors+Show Affiliations

Yassen H
INSERM U272, Maternité Régionale Universitaire, Nancy.
Boutroy MJ
No affiliation info available
Monin P
No affiliation info available
Vert P
No affiliation info available

MeSH

AcebutololDiuresisFemaleHemodynamicsHumansHypertensionInfant, NewbornKidneyPregnancyPregnancy Complications, CardiovascularPrenatal Exposure Delayed EffectsProspective Studies

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

1497424

Citation

Yassen, H, et al. "[Hemodynamic and Renal Adaptation of Newborn Infants of Hypertensive Mothers Treated With Acebutolol]." Archives Francaises De Pediatrie, vol. 49, no. 4, 1992, pp. 351-5.
Yassen H, Boutroy MJ, Monin P, et al. [Hemodynamic and renal adaptation of newborn infants of hypertensive mothers treated with acebutolol]. Arch Fr Pediatr. 1992;49(4):351-5.
Yassen, H., Boutroy, M. J., Monin, P., & Vert, P. (1992). [Hemodynamic and renal adaptation of newborn infants of hypertensive mothers treated with acebutolol]. Archives Francaises De Pediatrie, 49(4), 351-5.
Yassen H, et al. [Hemodynamic and Renal Adaptation of Newborn Infants of Hypertensive Mothers Treated With Acebutolol]. Arch Fr Pediatr. 1992;49(4):351-5. PubMed PMID: 1497424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Hemodynamic and renal adaptation of newborn infants of hypertensive mothers treated with acebutolol]. AU - Yassen,H, AU - Boutroy,M J, AU - Monin,P, AU - Vert,P, PY - 1992/4/1/pubmed PY - 1992/4/1/medline PY - 1992/4/1/entrez SP - 351 EP - 5 JF - Archives francaises de pediatrie JO - Arch Fr Pediatr VL - 49 IS - 4 N2 - A prospective study of the hemodynamic and renal changes was undertaken in 11 neonates whose mothers were treated with acebutolol for hypertension during pregnancy, compared with a control group of 11 infants born to normotensive mothers. Monitoring of the cardio-respiratory system was performed for a period of 4 days. Renal function was studied during 2 periods (12-36, 60-84 hours of life). Hemodynamic failure was observed in 5 of 11 children from treated mothers. The data concerning the renal function of treated group showed: 1) a diuresis significantly lower during the first period (p less than 0.05); 2) the absence of significant rise in the glomerular filtration rates during the second period; 3) a lower sodium balance during the 1st and 2nd periods (p less than 0.02 and p less than 0.05), a lower calcium balance during the 1st period (p less than 0.01). No relationship was found between the renal changes and the hemodynamic disturbances. The direct effect of the drug on the glomerular and tubular functions and/or the renal arteriolar vasomotricity could explain these changes in the renal function in the newborns prenatally exposed to acebutolol. SN - 0003-9764 UR - https://www.unboundmedicine.com/medline/citation/1497424/[Hemodynamic_and_renal_adaptation_of_newborn_infants_of_hypertensive_mothers_treated_with_acebutolol]_ DB - PRIME DP - Unbound Medicine ER -