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Effects of different quantities of fat on serum and liver lipids, phospholipid class distribution and fatty acid composition in alcohol-treated rats.
J Nutr Sci Vitaminol (Tokyo). 2003 Dec; 49(6):367-74.JN

Abstract

The present study investigated the quantitative effect of dietary fats and ingestion of alcohol on serum and liver lipids, fatty acid bound to phospholipids and their class distribution of male Wistar rats. The rats in C (control) and A (alcohol) groups were fed a standard laboratory diet, HFC (high fat-control) and HFA (high fat-alcohol) groups were fed a high fat diet (standard diet supplemented with 20 g%w/w, sunflower oil: lard mixture 1: 1) for 6 wk. Alcohol-treated rats consumed alcohol at the rate of 9 g/kgbw/d (15-20% energy). Liver phospholipid (PL) content was decreased, and phospholipid/cholesterol liver molar ratio increased in the alcohol treated rats. The proportion of serum sphingophospholipid (Sph) was significantly lower and proportion of phosphatidylcholin (PC) significantly higher in serum PL in alcohol-treated rats. Phospholipid class distribution was unaffected by alcohol feeding in liver. Significantly lower levels of 16:1n-7 and higher levels of 20:5n-3 and 22:4n-6 in the serum PL were observed in the alcohol-treated rats. The groups on the HF diet increased levels of 20:4n-6, 22:4n-6 and total n-6, polyunsaturated fatty acid (PUFA) and decreased levels of 18:1n-9 and total monounsaturated fatty acids (MUFA)in both liver and serum PL, but n-3 fatty acid increased in serum PL and decreased in liver PL compared to groups on the standard diet. Alcohol fat interaction was evident in MUFA and PUFA/SFA in serum PL and n-6, MUFA, PUFA and polyunsaturated/saturated fatty acid ratios (PUFA/SFA) in liver PL. This study showed that the high fat intake in alcohol-treated rats increased levels of 20:4n-6, 22:4n-6 and 20:4/18:2 ratio, and decreased level of 18:1n-9 in liver and serum phospholipids.

Authors+Show Affiliations

Institute for Medical Research, Laboratory for Nutrition & Metabolism, PO Box 102, Dr Subotica 4a, 11 129, Belgrade, Serbia and Montenegro. danijelar@imi.bg.ac.yuNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14974725

Citation

Ristić-Medić, Danijela, et al. "Effects of Different Quantities of Fat On Serum and Liver Lipids, Phospholipid Class Distribution and Fatty Acid Composition in Alcohol-treated Rats." Journal of Nutritional Science and Vitaminology, vol. 49, no. 6, 2003, pp. 367-74.
Ristić-Medić D, Ristić G, Tepsić V, et al. Effects of different quantities of fat on serum and liver lipids, phospholipid class distribution and fatty acid composition in alcohol-treated rats. J Nutr Sci Vitaminol (Tokyo). 2003;49(6):367-74.
Ristić-Medić, D., Ristić, G., Tepsić, V., & Ristić, G. N. (2003). Effects of different quantities of fat on serum and liver lipids, phospholipid class distribution and fatty acid composition in alcohol-treated rats. Journal of Nutritional Science and Vitaminology, 49(6), 367-74.
Ristić-Medić D, et al. Effects of Different Quantities of Fat On Serum and Liver Lipids, Phospholipid Class Distribution and Fatty Acid Composition in Alcohol-treated Rats. J Nutr Sci Vitaminol (Tokyo). 2003;49(6):367-74. PubMed PMID: 14974725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of different quantities of fat on serum and liver lipids, phospholipid class distribution and fatty acid composition in alcohol-treated rats. AU - Ristić-Medić,Danijela, AU - Ristić,Gordana, AU - Tepsić,Vesna, AU - Ristić,Gordana N, PY - 2004/2/21/pubmed PY - 2004/7/3/medline PY - 2004/2/21/entrez SP - 367 EP - 74 JF - Journal of nutritional science and vitaminology JO - J Nutr Sci Vitaminol (Tokyo) VL - 49 IS - 6 N2 - The present study investigated the quantitative effect of dietary fats and ingestion of alcohol on serum and liver lipids, fatty acid bound to phospholipids and their class distribution of male Wistar rats. The rats in C (control) and A (alcohol) groups were fed a standard laboratory diet, HFC (high fat-control) and HFA (high fat-alcohol) groups were fed a high fat diet (standard diet supplemented with 20 g%w/w, sunflower oil: lard mixture 1: 1) for 6 wk. Alcohol-treated rats consumed alcohol at the rate of 9 g/kgbw/d (15-20% energy). Liver phospholipid (PL) content was decreased, and phospholipid/cholesterol liver molar ratio increased in the alcohol treated rats. The proportion of serum sphingophospholipid (Sph) was significantly lower and proportion of phosphatidylcholin (PC) significantly higher in serum PL in alcohol-treated rats. Phospholipid class distribution was unaffected by alcohol feeding in liver. Significantly lower levels of 16:1n-7 and higher levels of 20:5n-3 and 22:4n-6 in the serum PL were observed in the alcohol-treated rats. The groups on the HF diet increased levels of 20:4n-6, 22:4n-6 and total n-6, polyunsaturated fatty acid (PUFA) and decreased levels of 18:1n-9 and total monounsaturated fatty acids (MUFA)in both liver and serum PL, but n-3 fatty acid increased in serum PL and decreased in liver PL compared to groups on the standard diet. Alcohol fat interaction was evident in MUFA and PUFA/SFA in serum PL and n-6, MUFA, PUFA and polyunsaturated/saturated fatty acid ratios (PUFA/SFA) in liver PL. This study showed that the high fat intake in alcohol-treated rats increased levels of 20:4n-6, 22:4n-6 and 20:4/18:2 ratio, and decreased level of 18:1n-9 in liver and serum phospholipids. SN - 0301-4800 UR - https://www.unboundmedicine.com/medline/citation/14974725/Effects_of_different_quantities_of_fat_on_serum_and_liver_lipids_phospholipid_class_distribution_and_fatty_acid_composition_in_alcohol_treated_rats_ L2 - https://medlineplus.gov/dietaryfats.html DB - PRIME DP - Unbound Medicine ER -