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Use of a new drug delivery formulation of the gonadotrophin-releasing hormone analogue Deslorelin for reversible long-term contraception in male dogs.
Reprod Fertil Dev. 2003; 15(6):317-22.RF

Abstract

In the present study, we tested the effect of treatment with a slow-release implant containing the gonadotrophin-releasing hormone agonist Deslorelin(TM) (Peptech Animal Health Australia, North Ryde, NSW, Australia) on pituitary and testicular function in mature male dogs. Four dogs were treated with Deslorelin (6-mg implant) and four were used as controls (blank implant). In control dogs, there were no significant changes over the 12 months of the study in plasma concentrations of luteinising hormone (LH) or testosterone, or in testicular volume, semen output or semen quality. In Deslorelin-treated dogs, plasma concentrations of LH and testosterone were undetectable after 21 and 27 days, testicular volume fell to 35% of pretreatment values after 14 weeks and no ejaculates could be obtained after 6 weeks. Concentrations returned to the detectable range for testosterone after 44 weeks and for LH after 51 weeks and both were within the normal range after 52 weeks. Semen characteristics had recovered completely by 60 weeks after implantation. At this time, the testes and prostate glands were similar histologically to those of control dogs. We conclude that a single slow-release implant containing 6 mg Deslorelin has potential as a long-term, reversible antifertility agent for male dogs.

Authors+Show Affiliations

Division of Veterinary and Biomedical Sciences, Murdoch University, Murdoch, WA, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14975229

Citation

Junaidi, A, et al. "Use of a New Drug Delivery Formulation of the Gonadotrophin-releasing Hormone Analogue Deslorelin for Reversible Long-term Contraception in Male Dogs." Reproduction, Fertility, and Development, vol. 15, no. 6, 2003, pp. 317-22.
Junaidi A, Williamson PE, Cummins JM, et al. Use of a new drug delivery formulation of the gonadotrophin-releasing hormone analogue Deslorelin for reversible long-term contraception in male dogs. Reprod Fertil Dev. 2003;15(6):317-22.
Junaidi, A., Williamson, P. E., Cummins, J. M., Martin, G. B., Blackberry, M. A., & Trigg, T. E. (2003). Use of a new drug delivery formulation of the gonadotrophin-releasing hormone analogue Deslorelin for reversible long-term contraception in male dogs. Reproduction, Fertility, and Development, 15(6), 317-22.
Junaidi A, et al. Use of a New Drug Delivery Formulation of the Gonadotrophin-releasing Hormone Analogue Deslorelin for Reversible Long-term Contraception in Male Dogs. Reprod Fertil Dev. 2003;15(6):317-22. PubMed PMID: 14975229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Use of a new drug delivery formulation of the gonadotrophin-releasing hormone analogue Deslorelin for reversible long-term contraception in male dogs. AU - Junaidi,A, AU - Williamson,P E, AU - Cummins,J M, AU - Martin,G B, AU - Blackberry,M A, AU - Trigg,T E, PY - 2004/2/21/pubmed PY - 2007/9/13/medline PY - 2004/2/21/entrez SP - 317 EP - 22 JF - Reproduction, fertility, and development JO - Reprod. Fertil. Dev. VL - 15 IS - 6 N2 - In the present study, we tested the effect of treatment with a slow-release implant containing the gonadotrophin-releasing hormone agonist Deslorelin(TM) (Peptech Animal Health Australia, North Ryde, NSW, Australia) on pituitary and testicular function in mature male dogs. Four dogs were treated with Deslorelin (6-mg implant) and four were used as controls (blank implant). In control dogs, there were no significant changes over the 12 months of the study in plasma concentrations of luteinising hormone (LH) or testosterone, or in testicular volume, semen output or semen quality. In Deslorelin-treated dogs, plasma concentrations of LH and testosterone were undetectable after 21 and 27 days, testicular volume fell to 35% of pretreatment values after 14 weeks and no ejaculates could be obtained after 6 weeks. Concentrations returned to the detectable range for testosterone after 44 weeks and for LH after 51 weeks and both were within the normal range after 52 weeks. Semen characteristics had recovered completely by 60 weeks after implantation. At this time, the testes and prostate glands were similar histologically to those of control dogs. We conclude that a single slow-release implant containing 6 mg Deslorelin has potential as a long-term, reversible antifertility agent for male dogs. SN - 1031-3613 UR - https://www.unboundmedicine.com/medline/citation/14975229/Use_of_a_new_drug_delivery_formulation_of_the_gonadotrophin_releasing_hormone_analogue_Deslorelin_for_reversible_long_term_contraception_in_male_dogs_ L2 - http://www.publish.csiro.au/journals/abstractHTML.cfm?J=RD&V=15&I=6&F=RD03039abs.XML DB - PRIME DP - Unbound Medicine ER -