Tags

Type your tag names separated by a space and hit enter

Heart rate-corrected QT interval prolongation predicts risk of coronary heart disease in black and white middle-aged men and women: the ARIC study.
J Am Coll Cardiol 2004; 43(4):565-71JACC

Abstract

OBJECTIVES

We aimed to study the predictive value of heart rate-corrected QT interval (QTc) for incident coronary heart disease (CHD) and cardiovascular disease (CVD) mortality in the black and white general population, and to validate various QT measurements.

BACKGROUND

QTc prolongation is associated with higher risk of mortality in cardiac patients and in the general population. Little is known about the association with incident CHD. No previous studies included black populations.

METHODS

We studied the predictive value of QTc prolongation in a prospective population study of 14,548 black and white men and women, age 45 to 64 year. QT was determined by the NOVACODE program in the digital electrocardiogram recorded at baseline.

RESULTS

In quintiles of QTc, cardiovascular risk profile deteriorated with longer QTc, and risk of CHD and CVD mortality increased. The high risk in the upper quintile was mostly explained by the 10% with the longest QTc. The age-, gender-, and race-adjusted hazard ratios for CVD mortality and CHD in subjects with the longest 10% relative to the other 90% of the gender-specific QTc distribution were 5.13 (95% confidence interval 3.80 to 6.94) and 2.14 (95% confidence interval 1.71 to 2.69), respectively. The increased risk was partly, but not completely, attributable to other risk factors or the presence of chronic disease. The association was stronger in black than in white subjects. Manual- and machine-coded QT intervals were highly correlated, and the method of rate correction did not affect the observed associations.

CONCLUSIONS

Long QTc is associated with increased risk of CHD and CVD mortality in black and white healthy men and women.

Authors+Show Affiliations

Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA. JM.Dekker@vumc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14975464

Citation

Dekker, Jacqueline M., et al. "Heart Rate-corrected QT Interval Prolongation Predicts Risk of Coronary Heart Disease in Black and White Middle-aged Men and Women: the ARIC Study." Journal of the American College of Cardiology, vol. 43, no. 4, 2004, pp. 565-71.
Dekker JM, Crow RS, Hannan PJ, et al. Heart rate-corrected QT interval prolongation predicts risk of coronary heart disease in black and white middle-aged men and women: the ARIC study. J Am Coll Cardiol. 2004;43(4):565-71.
Dekker, J. M., Crow, R. S., Hannan, P. J., Schouten, E. G., & Folsom, A. R. (2004). Heart rate-corrected QT interval prolongation predicts risk of coronary heart disease in black and white middle-aged men and women: the ARIC study. Journal of the American College of Cardiology, 43(4), pp. 565-71.
Dekker JM, et al. Heart Rate-corrected QT Interval Prolongation Predicts Risk of Coronary Heart Disease in Black and White Middle-aged Men and Women: the ARIC Study. J Am Coll Cardiol. 2004 Feb 18;43(4):565-71. PubMed PMID: 14975464.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heart rate-corrected QT interval prolongation predicts risk of coronary heart disease in black and white middle-aged men and women: the ARIC study. AU - Dekker,Jacqueline M, AU - Crow,Richard S, AU - Hannan,Peter J, AU - Schouten,Evert G, AU - Folsom,Aaron R, AU - ,, PY - 2002/12/13/received PY - 2003/08/15/revised PY - 2003/09/17/accepted PY - 2004/2/21/pubmed PY - 2004/3/16/medline PY - 2004/2/21/entrez SP - 565 EP - 71 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 43 IS - 4 N2 - OBJECTIVES: We aimed to study the predictive value of heart rate-corrected QT interval (QTc) for incident coronary heart disease (CHD) and cardiovascular disease (CVD) mortality in the black and white general population, and to validate various QT measurements. BACKGROUND: QTc prolongation is associated with higher risk of mortality in cardiac patients and in the general population. Little is known about the association with incident CHD. No previous studies included black populations. METHODS: We studied the predictive value of QTc prolongation in a prospective population study of 14,548 black and white men and women, age 45 to 64 year. QT was determined by the NOVACODE program in the digital electrocardiogram recorded at baseline. RESULTS: In quintiles of QTc, cardiovascular risk profile deteriorated with longer QTc, and risk of CHD and CVD mortality increased. The high risk in the upper quintile was mostly explained by the 10% with the longest QTc. The age-, gender-, and race-adjusted hazard ratios for CVD mortality and CHD in subjects with the longest 10% relative to the other 90% of the gender-specific QTc distribution were 5.13 (95% confidence interval 3.80 to 6.94) and 2.14 (95% confidence interval 1.71 to 2.69), respectively. The increased risk was partly, but not completely, attributable to other risk factors or the presence of chronic disease. The association was stronger in black than in white subjects. Manual- and machine-coded QT intervals were highly correlated, and the method of rate correction did not affect the observed associations. CONCLUSIONS: Long QTc is associated with increased risk of CHD and CVD mortality in black and white healthy men and women. SN - 0735-1097 UR - https://www.unboundmedicine.com/medline/citation/14975464/Heart_rate_corrected_QT_interval_prolongation_predicts_risk_of_coronary_heart_disease_in_black_and_white_middle_aged_men_and_women:_the_ARIC_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735109703015420 DB - PRIME DP - Unbound Medicine ER -