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Modulatory effect of Scoparia dulcis in oxidative stress-induced lipid peroxidation in streptozotocin diabetic rats.
J Med Food. 2003 Winter; 6(4):379-86.JM

Abstract

In light of evidence that diabetes mellitus is associated with oxidative stress and altered antioxidant status, we investigated the effect of Scoparia dulcis plant extracts (SPEt) (aqueous, ethanolic, and chloroform) in streptozotocin diabetic rats. Significant increases in the activities of insulin, superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, reduced glutathione, vitamin C, and vitamin E were observed in liver, kidney, and brain on treatment with SPEt. In addition, the treated groups also showed significant decreases in blood glucose, thiobarbituric acid-reactive substances, and hydroperoxide formation in tissues, suggesting its role in protection against lipid peroxidation-induced membrane damage. Thus, the results of the present study indicate that extracts of S. dulcis, especially the aqueous extract, showed a modulatory effect by attenuating the above lipid peroxidation in streptozotocin diabetes.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Science, Annamalai University, Annamalai Nagar, Tamil Nadu, India.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14977448

Citation

Latha, M, and L Pari. "Modulatory Effect of Scoparia Dulcis in Oxidative Stress-induced Lipid Peroxidation in Streptozotocin Diabetic Rats." Journal of Medicinal Food, vol. 6, no. 4, 2003, pp. 379-86.
Latha M, Pari L. Modulatory effect of Scoparia dulcis in oxidative stress-induced lipid peroxidation in streptozotocin diabetic rats. J Med Food. 2003;6(4):379-86.
Latha, M., & Pari, L. (2003). Modulatory effect of Scoparia dulcis in oxidative stress-induced lipid peroxidation in streptozotocin diabetic rats. Journal of Medicinal Food, 6(4), 379-86.
Latha M, Pari L. Modulatory Effect of Scoparia Dulcis in Oxidative Stress-induced Lipid Peroxidation in Streptozotocin Diabetic Rats. J Med Food. 2003;6(4):379-86. PubMed PMID: 14977448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulatory effect of Scoparia dulcis in oxidative stress-induced lipid peroxidation in streptozotocin diabetic rats. AU - Latha,M, AU - Pari,L, PY - 2004/2/24/pubmed PY - 2004/9/28/medline PY - 2004/2/24/entrez SP - 379 EP - 86 JF - Journal of medicinal food JO - J Med Food VL - 6 IS - 4 N2 - In light of evidence that diabetes mellitus is associated with oxidative stress and altered antioxidant status, we investigated the effect of Scoparia dulcis plant extracts (SPEt) (aqueous, ethanolic, and chloroform) in streptozotocin diabetic rats. Significant increases in the activities of insulin, superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, reduced glutathione, vitamin C, and vitamin E were observed in liver, kidney, and brain on treatment with SPEt. In addition, the treated groups also showed significant decreases in blood glucose, thiobarbituric acid-reactive substances, and hydroperoxide formation in tissues, suggesting its role in protection against lipid peroxidation-induced membrane damage. Thus, the results of the present study indicate that extracts of S. dulcis, especially the aqueous extract, showed a modulatory effect by attenuating the above lipid peroxidation in streptozotocin diabetes. SN - 1096-620X UR - https://www.unboundmedicine.com/medline/citation/14977448/Modulatory_effect_of_Scoparia_dulcis_in_oxidative_stress_induced_lipid_peroxidation_in_streptozotocin_diabetic_rats_ L2 - https://www.liebertpub.com/doi/10.1089/109662003772519958?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -