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Alcohol intake, drinking patterns, and risk of prostate cancer in a large prospective cohort study.
Am J Epidemiol 2004; 159(5):444-53AJ

Abstract

Alcohol drinking has been extensively studied in relation to prostate cancer, yet findings on the direction of the association are equivocal. Previous studies have not examined drinking patterns. Thus, the authors prospectively evaluated the associations between these factors and risk of incident prostate cancer (n = 2,479) in a cohort study of 47,843 US men (1986-1998). The men completed a questionnaire at baseline that included information on consumption of specific types of alcohol and frequency of use. The authors estimated hazard ratios using Cox proportional hazards regression for average alcohol intake and number of days per week on which alcohol was consumed stratified by average weekly intake (<105 g/week vs. > or = 105 g/week). Compared with nondrinking, the hazard ratio for consumption increased slightly from an average of 5.0-14.9 g/day (hazard ratio (HR) = 1.05, 95% confidence interval (CI): 0.94, 1.18) to 30.0-49.9 g/day (HR = 1.13, 95% CI: 0.96, 1.33), but it was not increased at > or = 50 g/day (HR = 1.00, 95% CI: 0.77, 1.31) after adjustment for recent smoking and other factors. Compared with abstainers, risk was greatest among men who consumed an average of > or = 105 g/week but who drank on only 1-2 days per week (HR = 1.64, 95% CI: 1.13, 2.38). These results suggest that moderate or greater alcohol consumption is not a strong contributor to prostate cancer risk, except possibly in men who consume large amounts infrequently.

Authors+Show Affiliations

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA. eplatz@jhsph.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

14977640

Citation

Platz, Elizabeth A., et al. "Alcohol Intake, Drinking Patterns, and Risk of Prostate Cancer in a Large Prospective Cohort Study." American Journal of Epidemiology, vol. 159, no. 5, 2004, pp. 444-53.
Platz EA, Leitzmann MF, Rimm EB, et al. Alcohol intake, drinking patterns, and risk of prostate cancer in a large prospective cohort study. Am J Epidemiol. 2004;159(5):444-53.
Platz, E. A., Leitzmann, M. F., Rimm, E. B., Willett, W. C., & Giovannucci, E. (2004). Alcohol intake, drinking patterns, and risk of prostate cancer in a large prospective cohort study. American Journal of Epidemiology, 159(5), pp. 444-53.
Platz EA, et al. Alcohol Intake, Drinking Patterns, and Risk of Prostate Cancer in a Large Prospective Cohort Study. Am J Epidemiol. 2004 Mar 1;159(5):444-53. PubMed PMID: 14977640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol intake, drinking patterns, and risk of prostate cancer in a large prospective cohort study. AU - Platz,Elizabeth A, AU - Leitzmann,Michael F, AU - Rimm,Eric B, AU - Willett,Walter C, AU - Giovannucci,Edward, PY - 2004/2/24/pubmed PY - 2004/10/16/medline PY - 2004/2/24/entrez SP - 444 EP - 53 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 159 IS - 5 N2 - Alcohol drinking has been extensively studied in relation to prostate cancer, yet findings on the direction of the association are equivocal. Previous studies have not examined drinking patterns. Thus, the authors prospectively evaluated the associations between these factors and risk of incident prostate cancer (n = 2,479) in a cohort study of 47,843 US men (1986-1998). The men completed a questionnaire at baseline that included information on consumption of specific types of alcohol and frequency of use. The authors estimated hazard ratios using Cox proportional hazards regression for average alcohol intake and number of days per week on which alcohol was consumed stratified by average weekly intake (<105 g/week vs. > or = 105 g/week). Compared with nondrinking, the hazard ratio for consumption increased slightly from an average of 5.0-14.9 g/day (hazard ratio (HR) = 1.05, 95% confidence interval (CI): 0.94, 1.18) to 30.0-49.9 g/day (HR = 1.13, 95% CI: 0.96, 1.33), but it was not increased at > or = 50 g/day (HR = 1.00, 95% CI: 0.77, 1.31) after adjustment for recent smoking and other factors. Compared with abstainers, risk was greatest among men who consumed an average of > or = 105 g/week but who drank on only 1-2 days per week (HR = 1.64, 95% CI: 1.13, 2.38). These results suggest that moderate or greater alcohol consumption is not a strong contributor to prostate cancer risk, except possibly in men who consume large amounts infrequently. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/14977640/Alcohol_intake_drinking_patterns_and_risk_of_prostate_cancer_in_a_large_prospective_cohort_study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwh062 DB - PRIME DP - Unbound Medicine ER -