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A new hypotensive polyunsaturated fatty acid dietary combination regulates oleic acid accumulation by suppression of stearoyl CoA desaturase 1 gene expression in the SHR model of genetic hypertension.
FASEB J. 2004 Apr; 18(6):773-5.FJ

Abstract

Polyunsaturated fatty acids (PUFA) are known to repress SCD-1 gene expression, key enzyme of monounsaturated fatty acid biosynthesis. Alterations of the monounsaturated/saturated fatty acids ratio have been implicated in various diseases related to the metabolic syndrome, including hypertension. We previously evidenced that lipogenesis end-products accumulated in spontaneously hypertensive rats (SHR), and that a dietary combination of n-6/n-3 PUFA had hypotensive effects. Our present objective was to test the hypothesis that these SHR liver lipid disorders might be modulated, in response to this hypotensive combination, by changes in SCD-1 expression and activity. So we studied, in hepatocytes, SCD-1 transcription by Northern blotting, as well as plasma and liver fatty acid composition by gas-liquid chromatography. Liver SCD-1 gene expression was suppressed by 50%, and in different lipid classes, relative abundance of stearic and oleic acids decreased. Consequently, the Delta9 desaturation index, calculated from the ratio of oleic vs. stearic acids, decreased. In addition, the level of circulating saturated fatty acids decreased when one of oleic acids increased. These data provided evidence that the tested hypotensive PUFA combination reverses the high monounsaturated/saturated fatty acids ratio associated to hypertension in SHR, via a regulation monounsaturated fatty acid relative abundance by repression of SCD-1 gene.

Authors+Show Affiliations

UPRES Lipides et Nutrition EA 2422, IFR 92 Qualité des Aliments, Université de Bourgogne, Dijon, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14977874

Citation

Bellenger, J, et al. "A New Hypotensive Polyunsaturated Fatty Acid Dietary Combination Regulates Oleic Acid Accumulation By Suppression of Stearoyl CoA Desaturase 1 Gene Expression in the SHR Model of Genetic Hypertension." FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, vol. 18, no. 6, 2004, pp. 773-5.
Bellenger J, Bellenger S, Clément L, et al. A new hypotensive polyunsaturated fatty acid dietary combination regulates oleic acid accumulation by suppression of stearoyl CoA desaturase 1 gene expression in the SHR model of genetic hypertension. FASEB J. 2004;18(6):773-5.
Bellenger, J., Bellenger, S., Clément, L., Mandard, S., Diot, C., Poisson, J. P., & Narce, M. (2004). A new hypotensive polyunsaturated fatty acid dietary combination regulates oleic acid accumulation by suppression of stearoyl CoA desaturase 1 gene expression in the SHR model of genetic hypertension. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 18(6), 773-5.
Bellenger J, et al. A New Hypotensive Polyunsaturated Fatty Acid Dietary Combination Regulates Oleic Acid Accumulation By Suppression of Stearoyl CoA Desaturase 1 Gene Expression in the SHR Model of Genetic Hypertension. FASEB J. 2004;18(6):773-5. PubMed PMID: 14977874.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A new hypotensive polyunsaturated fatty acid dietary combination regulates oleic acid accumulation by suppression of stearoyl CoA desaturase 1 gene expression in the SHR model of genetic hypertension. AU - Bellenger,J, AU - Bellenger,S, AU - Clément,L, AU - Mandard,S, AU - Diot,C, AU - Poisson,J-P, AU - Narce,M, Y1 - 2004/02/20/ PY - 2004/2/24/pubmed PY - 2004/7/16/medline PY - 2004/2/24/entrez SP - 773 EP - 5 JF - FASEB journal : official publication of the Federation of American Societies for Experimental Biology JO - FASEB J VL - 18 IS - 6 N2 - Polyunsaturated fatty acids (PUFA) are known to repress SCD-1 gene expression, key enzyme of monounsaturated fatty acid biosynthesis. Alterations of the monounsaturated/saturated fatty acids ratio have been implicated in various diseases related to the metabolic syndrome, including hypertension. We previously evidenced that lipogenesis end-products accumulated in spontaneously hypertensive rats (SHR), and that a dietary combination of n-6/n-3 PUFA had hypotensive effects. Our present objective was to test the hypothesis that these SHR liver lipid disorders might be modulated, in response to this hypotensive combination, by changes in SCD-1 expression and activity. So we studied, in hepatocytes, SCD-1 transcription by Northern blotting, as well as plasma and liver fatty acid composition by gas-liquid chromatography. Liver SCD-1 gene expression was suppressed by 50%, and in different lipid classes, relative abundance of stearic and oleic acids decreased. Consequently, the Delta9 desaturation index, calculated from the ratio of oleic vs. stearic acids, decreased. In addition, the level of circulating saturated fatty acids decreased when one of oleic acids increased. These data provided evidence that the tested hypotensive PUFA combination reverses the high monounsaturated/saturated fatty acids ratio associated to hypertension in SHR, via a regulation monounsaturated fatty acid relative abundance by repression of SCD-1 gene. SN - 1530-6860 UR - https://www.unboundmedicine.com/medline/citation/14977874/A_new_hypotensive_polyunsaturated_fatty_acid_dietary_combination_regulates_oleic_acid_accumulation_by_suppression_of_stearoyl_CoA_desaturase_1_gene_expression_in_the_SHR_model_of_genetic_hypertension_ L2 - https://doi.org/10.1096/fj.03-0950fje DB - PRIME DP - Unbound Medicine ER -