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Antitumor activity and antioxidant status of Caesalpinia bonducella against Ehrlich ascites carcinoma in Swiss albino mice.

Abstract

The methanol extract of Caesalpinia bonducella FLEMING (Caesalpiniaceae) leaves (MECB) were evaluated for antitumor activity against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. The extract was administered at the doses of 50, 100, and 200 mg/kg body weight per day for 14 days after 24 h of tumor inoculation. After the last dose and 18 h fasting, the mice were sacrificed. The present study deals with the effect of MECB on the growth of transplantable murine tumor, life span of EAC-bearing hosts, hematological profile, and biochemical parameters such as lipid peroxidation (LPO), glutathione content (GSH), superoxide dismutase (SOD), and catalase (CAT) activities. MECB caused significant (P<0.01) decrease in tumor volume, packed cell volume, and viable cell count; and it prolonged the life span of EAC-tumor bearing mice. Hematological profile converted to more or less normal levels in extract-treated mice. MECB significantly (P<0.05) decreased the levels of lipid peroxidation and significantly (P<0.05) increased the levels of GSH, SOD, and CAT. The MECB was found to be devoid of conspicuous short-term toxicity in the mice when administered daily (i.p.) for 14 days at the doses of 50, 100, 200, and 300 mg/kg. The treated mice showed conspicuous toxic symptoms only at 300 mg/kg. The results indicate that MECB exhibited significant antitumor and antioxidant activity in EAC-bearing mice.

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  • Authors+Show Affiliations

    ,

    Division of Pharmacology and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. sambathju2002@yahoo.co.in

    , , ,

    Source

    Journal of pharmacological sciences 94:2 2004 Feb pg 177-84

    MeSH

    Animals
    Antineoplastic Agents, Phytogenic
    Antioxidants
    Caesalpinia
    Carcinoma, Ehrlich Tumor
    Lipid Peroxidation
    Male
    Mice
    Plant Extracts
    Plant Leaves

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    14978356

    Citation

    TY - JOUR T1 - Antitumor activity and antioxidant status of Caesalpinia bonducella against Ehrlich ascites carcinoma in Swiss albino mice. AU - Gupta,Malaya, AU - Mazumder,Upal Kanti, AU - Kumar,Ramanathan Sambath, AU - Sivakumar,Thangavel, AU - Vamsi,Madgula Lakshmi Mohan, PY - 2004/2/24/pubmed PY - 2004/10/22/medline PY - 2004/2/24/entrez SP - 177 EP - 84 JF - Journal of pharmacological sciences JO - J. Pharmacol. Sci. VL - 94 IS - 2 N2 - The methanol extract of Caesalpinia bonducella FLEMING (Caesalpiniaceae) leaves (MECB) were evaluated for antitumor activity against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. The extract was administered at the doses of 50, 100, and 200 mg/kg body weight per day for 14 days after 24 h of tumor inoculation. After the last dose and 18 h fasting, the mice were sacrificed. The present study deals with the effect of MECB on the growth of transplantable murine tumor, life span of EAC-bearing hosts, hematological profile, and biochemical parameters such as lipid peroxidation (LPO), glutathione content (GSH), superoxide dismutase (SOD), and catalase (CAT) activities. MECB caused significant (P<0.01) decrease in tumor volume, packed cell volume, and viable cell count; and it prolonged the life span of EAC-tumor bearing mice. Hematological profile converted to more or less normal levels in extract-treated mice. MECB significantly (P<0.05) decreased the levels of lipid peroxidation and significantly (P<0.05) increased the levels of GSH, SOD, and CAT. The MECB was found to be devoid of conspicuous short-term toxicity in the mice when administered daily (i.p.) for 14 days at the doses of 50, 100, 200, and 300 mg/kg. The treated mice showed conspicuous toxic symptoms only at 300 mg/kg. The results indicate that MECB exhibited significant antitumor and antioxidant activity in EAC-bearing mice. SN - 1347-8613 UR - https://www.unboundmedicine.com/medline/citation/14978356/Antitumor_activity_and_antioxidant_status_of_Caesalpinia_bonducella_against_Ehrlich_ascites_carcinoma_in_Swiss_albino_mice_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/jphs/94.177?from=PubMed ER -