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Omega-3 fatty acids for the prevention of postpartum depression: negative data from a preliminary, open-label pilot study.
Depress Anxiety. 2004; 19(1):20-3.DA

Abstract

Based on the putative relationship between depleted omega-3 fatty acids and postpartum depression, we initiated an open-label pilot study of omega-3 fatty acid supplementation with the aim of preventing postpartum depression. Euthymic pregnant females with a past history of depression in the postpartum period were started on 2960 mg of fish oil (1.4:1 eicosapentaenoic acid:docosahexaenoic acid) per day between the 34th to 36th week of pregnancy and assessed through 12 weeks postpartum. Four of seven participants had a depressive episode during the study period. No participants withdrew from the study due to adverse events. This preliminary, small, open-label pilot study failed to show promising results for the use of omega-3 fatty acid monotherapy beginning at 34 to 36 weeks gestation for the prevention of postpartum depression in patients with a prior postpartum depression history. Controlled studies are lacking.

Authors+Show Affiliations

Department of Psychiatry, Baylor College of Medicine, Houston, Texas 77030, USA. laurenm@bcm.tmc.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

14978781

Citation

Marangell, Lauren B., et al. "Omega-3 Fatty Acids for the Prevention of Postpartum Depression: Negative Data From a Preliminary, Open-label Pilot Study." Depression and Anxiety, vol. 19, no. 1, 2004, pp. 20-3.
Marangell LB, Martinez JM, Zboyan HA, et al. Omega-3 fatty acids for the prevention of postpartum depression: negative data from a preliminary, open-label pilot study. Depress Anxiety. 2004;19(1):20-3.
Marangell, L. B., Martinez, J. M., Zboyan, H. A., Chong, H., & Puryear, L. J. (2004). Omega-3 fatty acids for the prevention of postpartum depression: negative data from a preliminary, open-label pilot study. Depression and Anxiety, 19(1), 20-3.
Marangell LB, et al. Omega-3 Fatty Acids for the Prevention of Postpartum Depression: Negative Data From a Preliminary, Open-label Pilot Study. Depress Anxiety. 2004;19(1):20-3. PubMed PMID: 14978781.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Omega-3 fatty acids for the prevention of postpartum depression: negative data from a preliminary, open-label pilot study. AU - Marangell,Lauren B, AU - Martinez,James M, AU - Zboyan,Holly A, AU - Chong,Helen, AU - Puryear,Lucy J, PY - 2004/2/24/pubmed PY - 2004/8/3/medline PY - 2004/2/24/entrez SP - 20 EP - 3 JF - Depression and anxiety JO - Depress Anxiety VL - 19 IS - 1 N2 - Based on the putative relationship between depleted omega-3 fatty acids and postpartum depression, we initiated an open-label pilot study of omega-3 fatty acid supplementation with the aim of preventing postpartum depression. Euthymic pregnant females with a past history of depression in the postpartum period were started on 2960 mg of fish oil (1.4:1 eicosapentaenoic acid:docosahexaenoic acid) per day between the 34th to 36th week of pregnancy and assessed through 12 weeks postpartum. Four of seven participants had a depressive episode during the study period. No participants withdrew from the study due to adverse events. This preliminary, small, open-label pilot study failed to show promising results for the use of omega-3 fatty acid monotherapy beginning at 34 to 36 weeks gestation for the prevention of postpartum depression in patients with a prior postpartum depression history. Controlled studies are lacking. SN - 1091-4269 UR - https://www.unboundmedicine.com/medline/citation/14978781/Omega_3_fatty_acids_for_the_prevention_of_postpartum_depression:_negative_data_from_a_preliminary_open_label_pilot_study_ L2 - https://doi.org/10.1002/da.10148 DB - PRIME DP - Unbound Medicine ER -