Tags

Type your tag names separated by a space and hit enter

Acute Wernicke's encephalopathy following bariatric surgery: clinical course and MRI correlation.
Obes Surg. 2004 Jan; 14(1):129-32.OS

Abstract

Postoperative complications and nutritional deficits resulting from bariatric surgery can lead to severe vitamin-deficiency states, such as Wernicke's encephalopathy (WE). Patients with acute WE generally present with the classic clinical triad of inattentiveness, ataxia, and ophthalmoplegia. We describe a patient who presented with acute WE at 2 months after laparoscopic bariatric surgery. Initial MRI of the brain demonstrated the characteristic injuries of WE, and repeat imaging showed resolution after 4 months of thiamine supplementation, at which time the patient had normal gait but persistent memory deficits. Even with early recognition and aggressive therapy, acute WE commonly results in permanent disability due to the irreversible cytotoxic effects on specific regions of the brain. Since the clinical onset of acute WE follows a predictable time-course in post-bariatric surgery patients with malnutrition, we recommend prevention by administration of parenteral thiamine beginning at 6 weeks postoperatively in malnourished patients.

Authors+Show Affiliations

Department of Neurology, Walter Reed Army Medical Center, Washington, DC 20307, USA. Yince.loh@na.amedd.army.milNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

14980048

Citation

Loh, Yince, et al. "Acute Wernicke's Encephalopathy Following Bariatric Surgery: Clinical Course and MRI Correlation." Obesity Surgery, vol. 14, no. 1, 2004, pp. 129-32.
Loh Y, Watson WD, Verma A, et al. Acute Wernicke's encephalopathy following bariatric surgery: clinical course and MRI correlation. Obes Surg. 2004;14(1):129-32.
Loh, Y., Watson, W. D., Verma, A., Chang, S. T., Stocker, D. J., & Labutta, R. J. (2004). Acute Wernicke's encephalopathy following bariatric surgery: clinical course and MRI correlation. Obesity Surgery, 14(1), 129-32.
Loh Y, et al. Acute Wernicke's Encephalopathy Following Bariatric Surgery: Clinical Course and MRI Correlation. Obes Surg. 2004;14(1):129-32. PubMed PMID: 14980048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute Wernicke's encephalopathy following bariatric surgery: clinical course and MRI correlation. AU - Loh,Yince, AU - Watson,William D, AU - Verma,Ajay, AU - Chang,Suyoung T, AU - Stocker,Derek J, AU - Labutta,Robert J, PY - 2004/2/26/pubmed PY - 2004/6/21/medline PY - 2004/2/26/entrez SP - 129 EP - 32 JF - Obesity surgery JO - Obes Surg VL - 14 IS - 1 N2 - Postoperative complications and nutritional deficits resulting from bariatric surgery can lead to severe vitamin-deficiency states, such as Wernicke's encephalopathy (WE). Patients with acute WE generally present with the classic clinical triad of inattentiveness, ataxia, and ophthalmoplegia. We describe a patient who presented with acute WE at 2 months after laparoscopic bariatric surgery. Initial MRI of the brain demonstrated the characteristic injuries of WE, and repeat imaging showed resolution after 4 months of thiamine supplementation, at which time the patient had normal gait but persistent memory deficits. Even with early recognition and aggressive therapy, acute WE commonly results in permanent disability due to the irreversible cytotoxic effects on specific regions of the brain. Since the clinical onset of acute WE follows a predictable time-course in post-bariatric surgery patients with malnutrition, we recommend prevention by administration of parenteral thiamine beginning at 6 weeks postoperatively in malnourished patients. SN - 0960-8923 UR - https://www.unboundmedicine.com/medline/citation/14980048/Acute_Wernicke's_encephalopathy_following_bariatric_surgery:_clinical_course_and_MRI_correlation_ L2 - https://dx.doi.org/10.1381/096089204772787437 DB - PRIME DP - Unbound Medicine ER -