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Droperidol vs prochlorperazine for the treatment of acute headache.
J Emerg Med. 2004 Feb; 26(2):145-50.JE

Abstract

To determine if droperidol i.v. is as effective as prochlorperazine i.v. in the emergency department (ED) treatment of uncomplicated headache, a randomized, controlled, blinded study was conducted in the Emergency Departments of two urban teaching hospitals. Patients >or= 18 years old with crescendo-onset headache were eligible for inclusion. Ninety-six patients (48 in each group) were randomized to receive droperidol 2.5 mg i.v. or prochlorperazine 10 mg i.v. Baseline characteristics were similar between the two study groups. For the main study outcome, 83.3% in the droperidol group and 72.3% in the prochlorperazine group reported 50% pain reduction at 30 min (p <.01; one-sided test of equivalence). The mean decrease in headache intensity was 79.1% (SD 28.5%) in the droperidol group and 72.1% (SD 28.0%) in the prochlorperazine group (p =.23). It is concluded that droperidol i.v. provided a similar reduction of headache as achieved with prochlorperazine i.v. with a similar incidence of akathisia.

Authors+Show Affiliations

Department of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

14980334

Citation

Weaver, Christopher S., et al. "Droperidol Vs Prochlorperazine for the Treatment of Acute Headache." The Journal of Emergency Medicine, vol. 26, no. 2, 2004, pp. 145-50.
Weaver CS, Jones JB, Chisholm CD, et al. Droperidol vs prochlorperazine for the treatment of acute headache. J Emerg Med. 2004;26(2):145-50.
Weaver, C. S., Jones, J. B., Chisholm, C. D., Foley, M. J., Giles, B. K., Somerville, G. G., Brizendine, E. J., & Cordell, W. H. (2004). Droperidol vs prochlorperazine for the treatment of acute headache. The Journal of Emergency Medicine, 26(2), 145-50.
Weaver CS, et al. Droperidol Vs Prochlorperazine for the Treatment of Acute Headache. J Emerg Med. 2004;26(2):145-50. PubMed PMID: 14980334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Droperidol vs prochlorperazine for the treatment of acute headache. AU - Weaver,Christopher S, AU - Jones,James B, AU - Chisholm,Carey D, AU - Foley,Michael J, AU - Giles,Beverly K, AU - Somerville,Geoffrey G, AU - Brizendine,Edward J, AU - Cordell,William H, PY - 2002/09/30/received PY - 2003/04/01/revised PY - 2003/05/12/accepted PY - 2004/2/26/pubmed PY - 2004/6/16/medline PY - 2004/2/26/entrez SP - 145 EP - 50 JF - The Journal of emergency medicine JO - J Emerg Med VL - 26 IS - 2 N2 - To determine if droperidol i.v. is as effective as prochlorperazine i.v. in the emergency department (ED) treatment of uncomplicated headache, a randomized, controlled, blinded study was conducted in the Emergency Departments of two urban teaching hospitals. Patients >or= 18 years old with crescendo-onset headache were eligible for inclusion. Ninety-six patients (48 in each group) were randomized to receive droperidol 2.5 mg i.v. or prochlorperazine 10 mg i.v. Baseline characteristics were similar between the two study groups. For the main study outcome, 83.3% in the droperidol group and 72.3% in the prochlorperazine group reported 50% pain reduction at 30 min (p <.01; one-sided test of equivalence). The mean decrease in headache intensity was 79.1% (SD 28.5%) in the droperidol group and 72.1% (SD 28.0%) in the prochlorperazine group (p =.23). It is concluded that droperidol i.v. provided a similar reduction of headache as achieved with prochlorperazine i.v. with a similar incidence of akathisia. SN - 0736-4679 UR - https://www.unboundmedicine.com/medline/citation/14980334/Droperidol_vs_prochlorperazine_for_the_treatment_of_acute_headache_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0736467903003408 DB - PRIME DP - Unbound Medicine ER -