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Development of pulsatile release tablets with swelling and rupturable layers.
J Control Release. 2004 Mar 05; 95(2):147-59.JC

Abstract

A tablet system consisting of cores coated with two layers of swelling and rupturable coatings was prepared and evaluated as pulsatile drug delivery system. Cores containing buflomedil HCl as model drug were prepared by direct compression of different ratios of spray-dried lactose and microcrystalline cellulose and were then coated sequentially with an inner swelling layer containing a superdisintegrant (croscarmellose sodium) and an outer rupturable layer of ethylcellulose. The effect of core composition, level of swelling layer and rupturable coating, and magnesium stearate in rupturable layer was investigated. Mechanical properties of ethylcellulose films in the dry and wet state were characterized with a puncture test. Rupture and dissolution tests were performed using the USP XXIV paddle method at 50 rpm in 0.1 N HCl. The lag time of the pulsatile release tablets decreased with increasing amount of microcrystalline cellulose in the cores and increased with increasing levels of both swelling layer and rupturable ethylcellulose coating. Increasing levels of the ethylcellulose coating retarded the water uptake and thus prolonged the lag time. Addition of magnesium stearate to the ethylcellulose coating lowered the mechanical strength of the film and improved the robustness of the system.

Authors+Show Affiliations

Sungthongjeen S
Department of Manufacturing Pharmacy, Faculty of Pharmacy, Mahidol University, Sri-Ayudhya Road, Bangkok 10400, Thailand.
Puttipipatkhachorn S
No affiliation info available
Paeratakul O
No affiliation info available
Dashevsky A
No affiliation info available
Bodmeier R
No affiliation info available

MeSH

CelluloseDelayed-Action PreparationsDrug Delivery SystemsHardnessMicroscopy, Electron, ScanningPharmaceutic AidsPovidoneSolubilityStearic AcidsSurface PropertiesTabletsWater

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

14980764

Citation

Sungthongjeen, Srisagul, et al. "Development of Pulsatile Release Tablets With Swelling and Rupturable Layers." Journal of Controlled Release : Official Journal of the Controlled Release Society, vol. 95, no. 2, 2004, pp. 147-59.
Sungthongjeen S, Puttipipatkhachorn S, Paeratakul O, et al. Development of pulsatile release tablets with swelling and rupturable layers. J Control Release. 2004;95(2):147-59.
Sungthongjeen, S., Puttipipatkhachorn, S., Paeratakul, O., Dashevsky, A., & Bodmeier, R. (2004). Development of pulsatile release tablets with swelling and rupturable layers. Journal of Controlled Release : Official Journal of the Controlled Release Society, 95(2), 147-59.
Sungthongjeen S, et al. Development of Pulsatile Release Tablets With Swelling and Rupturable Layers. J Control Release. 2004 Mar 5;95(2):147-59. PubMed PMID: 14980764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development of pulsatile release tablets with swelling and rupturable layers. AU - Sungthongjeen,Srisagul, AU - Puttipipatkhachorn,Satit, AU - Paeratakul,Ornlaksana, AU - Dashevsky,Andrei, AU - Bodmeier,Roland, PY - 2003/09/10/received PY - 2003/10/30/accepted PY - 2004/2/26/pubmed PY - 2004/10/16/medline PY - 2004/2/26/entrez SP - 147 EP - 59 JF - Journal of controlled release : official journal of the Controlled Release Society JO - J Control Release VL - 95 IS - 2 N2 - A tablet system consisting of cores coated with two layers of swelling and rupturable coatings was prepared and evaluated as pulsatile drug delivery system. Cores containing buflomedil HCl as model drug were prepared by direct compression of different ratios of spray-dried lactose and microcrystalline cellulose and were then coated sequentially with an inner swelling layer containing a superdisintegrant (croscarmellose sodium) and an outer rupturable layer of ethylcellulose. The effect of core composition, level of swelling layer and rupturable coating, and magnesium stearate in rupturable layer was investigated. Mechanical properties of ethylcellulose films in the dry and wet state were characterized with a puncture test. Rupture and dissolution tests were performed using the USP XXIV paddle method at 50 rpm in 0.1 N HCl. The lag time of the pulsatile release tablets decreased with increasing amount of microcrystalline cellulose in the cores and increased with increasing levels of both swelling layer and rupturable ethylcellulose coating. Increasing levels of the ethylcellulose coating retarded the water uptake and thus prolonged the lag time. Addition of magnesium stearate to the ethylcellulose coating lowered the mechanical strength of the film and improved the robustness of the system. SN - 0168-3659 UR - https://www.unboundmedicine.com/medline/citation/14980764/Development_of_pulsatile_release_tablets_with_swelling_and_rupturable_layers_ DB - PRIME DP - Unbound Medicine ER -